Seroprevalence of human parvovirus B19 in a suburban population in São Paulo, Brazil

Abstract

OBJECTIVE:To analyze the prevalence of IgG antibodies to human parvovirus B19. METHODS:Cross-sectional study in a suburban community in São Paulo, Southeastern Brazil, between November 1990 and January 1991. Randomly selected (N=435) representative samples of sera were collected from healthy children older than 15 days old and adults up to 40 years old. IgG antibodies were detected using ELISA. RESULTS:High prevalence of IgG antibodies to B19 parvovirus was found in 87% of newborns. The prevalence of maternally derived IgG antibodies exponentially plunged up to the 19th month of age. Low prevalence of antibodies was found in the fi rst 4 years of life, increasing up to 72% in those aged 31-40 years. It was estimated that the average age of fi rst infection in this population is 21 ± 7 years old and the optimal age for vaccination with a hypothetical vaccine would be 1 year of age.CONCLUSIONS: Parvovirus B19 IgG antibody prevalence was high in newborns and those aged 31-40 years. The analysis by age groups showed a pattern similar to that found in previous studies, i.e., low prevalence of infection in children that increases with age.

Seroepidemiological study of human parvovirus B19 among human immunodeficiency virus-infected patients in a medium-sized city in Rio de Janeiro, Brazil

“…The prevalence (91%) was higher than that observed in our patients. In fact, we found rates similar to those obtained in larger seroprevalence studies in Brazilian immunocompetent adults, whose seropositivity rates ranged from 71.6-73.7% (Nascimento et al 1990, Silva et al 2006, Huatuco et al 2008. Gyllensten et al (1994) searched retrospectively 69 HIV-infected patients with anaemia.…”

Parvovirus B19 Frequency in Exanthematic Cases Initialy Suspected as Measles or Rubella Infections in São Paulo, Brazil

“…The seroprevalence reach approximately 42% in the 5-31 age group, which results in high susceptibility during childbearing years with intense viral activity in the age groups, confirming an increasing trend in the proportion of seropositive individuals as age increases. This data is similar to other studies (Anderson 1987, Nascimento et al 1990, Abarca et al 2002, Ooi et al 2002, Ziyaeyan et al 2005, Wildig 2007, Huatuco et al 2008). …”

Molecular and phylogenetic analyses of human Parvovirus B19 isolated from Brazilian patients with sickle cell disease and β‐thalassemia major and healthy blood donors

“…Although, data on B19V seroprevalence in Brazil are available [Wermelinger et al, 2002; Huatuco et al, 2008; Amaku et al, 2009], the epidemiological aspects of this infection in patients with hemoglobinopathies have not been evaluated. A single study [Sant'Anna et al, 2002], which included a significant number of patients with sickle cell disease, revealed low anti‐B19 IgG reactivity (32.2%).…”