Seroprevalence of IgG antibodies against Bordetella pertussis in healthy individuals aged 4–24 years in Turkey

Çevik, Müge; Beyazova, Ufuk; Aral, Arzu; Çamurdan, Aysu Duyan; Özkan, Seçil; Sahın, Figen; Aybay, Cemalettin

doi:10.1111/j.1469-0691.2007.01926.x

Cited by 15 publications

(19 citation statements)

References 10 publications

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“…Although many studies have explained the seroprevalence of pertussis in industrialized countries, only few studies have reported its incidence in developing countries. This study showed that vaccine-induced immunity decreases by ages of 6-7 years, which was similar to the finding of several studies in the Middle East (4,11,12).…”

Section: Discussionsupporting

confidence: 91%

Seroprevalence of Pertussis in School-entry Age Children in Libya, A Cross-sectional Study

Abusrewil¹,

Abugalia²,

Almgadmi³

et al. 2018

J Pediatr Inf

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Objective: In Libya, no pertussis booster doses are administered to children after 18 months of age. In light of evidence of waning of vaccineinduced immunity to pertussis, this study aimed to evaluate the waning of immunity in vaccinated school-entry age children, as measured by susceptibility to infection at population level. For this purpose, IgG and IgA levels were measured as markers of recent (infection in the last 6 months) and non-recent infections (infection in the last 12 months). Material and Methods: This was a cross sectional study undertaken in Tripoli, in February 2015. Children of school-entry age (> 5 to ≤ 7 years) were recruited on convenience basis at vaccination centers. Sera were tested for antibodies to pertussis. Results: Samples from 791 children (421 males and 370 females, mean age 6.50 were tested). All of the participants had received 4 doses of Whole cell pertussis containing vaccine in the first 2 years of life. The prevalence of recent and non-recent pertussis infection were 4.8% and 2.5%, respectively. The proportion of children with undetectable level of IgG was 76.1. Conclusion: The findings of this study showed significant circulation of Bordotella pertussis among vaccinated children by school-entry age. The circulation of B. pertussis in this population may be an indirect sign of waned immunity, which is simply corroborated by the absence of detectable antibodies in 76.1% of the children.

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Section: Discussionsupporting

confidence: 91%

Seroprevalence of Pertussis in School-entry Age Children in Libya, A Cross-sectional Study

Abusrewil¹,

Abugalia²,

Almgadmi³

et al. 2018

J Pediatr Inf

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“…This type of increasing sero-prevalence with age has been observed with good immunization coverage during childhood [27]. A study conducted in Turkey, where the final dose of whole cell pertussis vaccine is given at the age of 18 months, the pertussis antibodies were highest at 51.4 U/mL in the 13 to 18 years age group similar to findings from this study [23]. In contrast, a study done in Nashville, where the last vaccine dose is given at the age of 4 to 6 years, two peaks of antibody titres were noted, one at the age range of 4 to 6 years while the other at 13 to 17 years [28].…”

Section: Discussionsupporting

confidence: 86%

“…The median anti PT IgG level was lowest in the 8 to 11 year age group. Several other studies done to determine the sero-prevalence of pertussis has shown similar findings [23]. A study done in the Czech Republic to determine levels of the anti-PT antibodies after childhood vaccination showed that seropositivity in children declines rapidly after the last dose of vaccination and the lowest level of anti PT antibodies were observed among preschool age group [24].…”

Section: Discussionmentioning

confidence: 60%

“…A study done in the Czech Republic to determine levels of the anti-PT antibodies after childhood vaccination showed that seropositivity in children declines rapidly after the last dose of vaccination and the lowest level of anti PT antibodies were observed among preschool age group [24]. According to a study conducted in Turkey, where the final dose of whole cell pertussis vaccine is given at the age of 18 months [23], the lowest geometric titer for the anti-pertussis antibodies were observed in the 4 to 6 years age group and 51.7% of this group were negative for pertussis antibodies [23]. Similarly a study conducted among Iranian medical students has reported a sero positivity of 47.6%.…”

Section: Discussionmentioning

confidence: 99%

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Seroprevalence of Bordetella pertussis specific Immunoglobulin G antibody levels among asymptomatic individuals aged 4 to 24 years: a descriptive cross sectional study from Sri Lanka

et al. 2016

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BackgroundIn Sri Lanka pertussis continues to circulate in the community and cases among adolescents and adults have been reported despite 95% coverage of the four dose pertussis vaccination during early childhood. Waning of immunity following natural infection or immunization may contribute to the persistent circulation. An adolescent booster dose is not included in the national immunization schedule of Sri Lanka, although this is routine practice in many countries. Therefore information on immunity to pertussis in the adolescent group is needed prior to considering vaccination schedule changes.MethodsThe quantitative determination of specific Immunoglobulin G antibodies to Bordetella pertussis toxin was done using a commercially available validated ELISA method. The antibody values were categorized into groups according to the interpretive criteria provided by the manufacturer. The values were <55 IU/mL, negative; 55–<60 IU/mL, borderline; 60–125 IU/mL, positive; >125, strongly positive respectively. Sera of 385 asymptomatic individuals aged 4 to 24 years admitted to surgical units of Lady Ridgeway Hospital, Colombo and Colombo South Teaching Hospital were used for the study. Mann-Whitney U and Kruskal-Wallis tests were used in analysis of results and p ≤0.05 was considered as statistically significant. Details of epidemiological variables were collected using a questionnaire and correlation with significant levels of pertussis antibodies was determined.ResultsMedian age of the study population was 12 years with 212 (55.1%) females. The median anti PT antibody level was 3.31 IU/mL and 352 (91%) had anti PT levels ≤55 IU/mL. Median of anti PT levels were 3.18 IU/mL for 4–7 years, 1.43 IU/mL (IQR 0.336–6.27) for 8–11 years, 4.28 IU/mL (IQR 0.978–13.39) for 12–15 years, 6.14 IU/mL for 16–19 years and 4.89 IU/mL for 20–24 years and the differences were statistically significant (p = 0.000). Females (p < 0.003) and those having a sibling aged ≥12 years (p = 0.017) had significantly higher anti PT levels.ConclusionsThe majority of the study population, especially 8 to 11 year age group had low anti PT IgG levels. The higher antibody titers in the 12–15 year age group seem to indicate infection in early adolescence. A booster dose of acellular pertussis vaccine need to be considered.

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“…Gender did not influence the seroimmunity in our study; the same was reported by several other investigators. [23][24][25][26] In the current study, serum pertussis IgG titres increased with age among the infants' group being lowest below 6 months of age and higher in the 12 to 24 months old which is expected due to the receival of booster doses of the vaccine. A relevant study showed that pertussis antibody levels >30 U/ml were observed with higher frequency in infants younger than 2 years of age who completed the vaccination schedule .…”

Section: Discussionmentioning

confidence: 53%

Pertussis seroimmunity in mother-neonate pairs and other pediatric age groups from Egypt

Hossny

El‐Ghoneimy

Soliman

et al. 2019

Egypt J Pediatr Allergy Immunol

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Background: Despite the widespread availability of 2 classes of effective vaccines, whole cell and acellular, pertussis has resurged as a serious public health problem. We sought to investigate the pertussis immune status of mother-neonate pairs and children in our country where pertussis vaccination is obligatory. Methods: This cross-sectional study included 75 healthy full-term neonates and their mothers, 100 infants (2-24 months), 170 children (2-12 years) and 80 adolescents (12-18 years). Serum pertussis IgG was measured in all enrolled subjects. A positive titre was defined as >24 U/ml. Results: Positive pertussis IgG levels were detected in 69 of the mothers (92%), in 63 of their newborns (84%). Seroimmunity to pertussis was positively noted in 55% of infants, 82.2% of preschool children, 77.5% of school-aged children and 75% in adolescents. Serum pertussis IgG titers among the neonates showed a significant positive correlation with the maternal titers (P=0.00001). Higher rates of pertussis seroimmunity was observed among residents in urban and suburban areas as compared to those living in rural areas (P<0.05). Conclusion: This pilot study may suggest the presence of sufficient pertussis seroimmunity rates in the studied age groups. Still, there were some failures in immune acquisition probably due to inefficient vaccination in some localities or waning of immunity with age. Wider scale studies would allow better insight into the pertussis immune status in our country and hence the need for booster immunization.

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Seroprevalence of IgG antibodies against Bordetella pertussis in healthy individuals aged 4–24 years in Turkey

Cited by 15 publications

References 10 publications

Seroprevalence of Pertussis in School-entry Age Children in Libya, A Cross-sectional Study

Seroprevalence of Pertussis in School-entry Age Children in Libya, A Cross-sectional Study

Seroprevalence of Bordetella pertussis specific Immunoglobulin G antibody levels among asymptomatic individuals aged 4 to 24 years: a descriptive cross sectional study from Sri Lanka

Pertussis seroimmunity in mother-neonate pairs and other pediatric age groups from Egypt

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