Seroprevalence of infectious markers & their trends in blood donors in a hospital based blood bank in north India

Abstract

Background & objectives:Hepatitis B virus (HBV), human immunodeficiency virus (HIV), hepatitis C virus (HCV) and syphilis infections pose a great threat to blood safety. This study was undertaken to investigate the seroprevalence of serologic markers for transfusion transmitted infections (TTIs) among blood donors at a hospital based blood centre in north India over a period of nine years.Methods:The results of serologic markers for TTIs (HBsAg, anti-HCV, anti-HIV and syphilis) of all blood donations (both voluntary and replacement) at our hospital from January 2005 to December 2013 were screened. Additional analysis was conducted to examine the prevalence trends associated with each of the positive marker.Results:The data of 180,477 donors [173,019 (95.86%) males and 7,458 (4.13%) females] were analyzed. Replacement donations [174,939 (96.93%)] represented the majority whereas, only 5,538 (3.06%) donations were from the voluntary donors. The risk of blood being reactive was three times higher in male donors when compared with the female donors. The risk of blood being reactive for one or more infectious markers was 2.1 times higher in replacement donors when compared with the voluntary donors. Seropositivity of HIV, HBsAg, HBcAb, syphilis showed a significant decreasing trend (P<0.05) while there was an increasing trend in HCV infection which was insignificant.Interpretation & conclusions:This study reflects that the risk of TTIs has been decreased over time with respect to HIV, HBV and syphilis, but the trends for HCV remains almost the same in blood donors. Blood transfusion remains a risk factor for the spread of blood-borne infections. Therefore, improvements are needed to strengthen both safety and availability of blood.

Transfusion-transmissible infection surveillance among blood donors in Southwest Ethiopia: A six years retrospective study

“…The present result was lower than previous studies reported from south (Wolaita, 9.5%), east (Jigjiga, 11.5%), and northeast (Gondar, 9.5%) parts of Ethiopia [8][9][10]. It is also lower compared to similar studies from other parts of the world, 28.8% and 11.9% in Nigeria and India, respectively [17,18]. However, the prevalence of TTI reported in the present study is higher than the study reported from Iran, 0.254% [19].…”

“…This prevalence is lower than studies from Ethiopia, 0.7% [8], 0.4%, [10], and 8.5% [9], and also from another parts of the world, 0.43% in India [17], 3.0% in Sudan [5], and 0.51% in China [23]. But, higher than reports from India, 0.18% [20].…”

“…But, higher than reports from India, 0.18% [20]. [17]. It is probably due to a similarity in specificity and sensitivity of screening tests used for anti-HCV marker detection.…”

Hepatitis B Virus Burden in Jammu (J&K): A Maiden Study

“…On the contrary, in a retro-prospective study conducted at a hospital in Nepal and a tertiary care hospital at North Western Nigeria seroprevelance of 4.19% (22) and 9.2% (23) has been reported. In another pivotal study conducted at a North Indian Hospital from 2005-2013 seroprevelance was found to range from 0.92% to 1.75% (24) indicative of consistent infection. In a meta-analysis of 54 studies of HBsAg prevalence in India by Batham et al, a prevalence of 2.4% and 15.9% among the nontribal and tribal population respectively was reported (25) .…”

Seroprevalence of Common Transfusion Transmitted Infections among Blood Donors in Tertiary Care Rural Hospital of Central India: A Six Years Study

“…So, the seropositivity was more in voluntary donors as compared to replacement donors. Contradictory to this Makroo RN et al [17] and Jamsin Jasani et al [18] found that the seropositivity is more in replacement donors as compared to voluntary donors. They also found that males were more affected as compared to female.…”