Seroprevalence of sperm antibody in selected Minnesota swine breeding herds

Fayemi, O.; Morrison, Robert B.; Joo, Heesoo

doi:10.1016/0378-4320(92)90148-7

Cited by 4 publications

(5 citation statements)

References 13 publications

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“…These findings are in accordance with the results in boars published by Fayemi et al (1992). The prepubertal stage is a period in which several changes occur in the developing reproductive system.…”

Section: Discussionsupporting

confidence: 83%

“…In older bulls (more than 25 months), no significant changes in the incidence of antibodies were observed unlike of Fayemi et al (1992) who recorded a continuous increase of antibodies in boars. Similarly, Flickinger et al (1997) observed in rats ASA formation since the day 56, and a significant increase between 91 and 128 days of age.…”

Section: Discussionmentioning

confidence: 83%

“…The first study on the prevalence of antisperm antibodies in blood sera of boars and sows was published by Fayemi et al (1992); in bulls and boars by Zral˘et al (1997). Most of the unexplained questions concern the etiology and pathogenic mechanisms of functional changes in sperms induced by antibodies, and the subsequent subfertility (Gandini et al 1995).…”

mentioning

confidence: 99%

“…Generally, ASA formation can be induced primarily during infectious and noninfectious inflammations, or by obstruction of testicular efferent duct. The incidence of ASA was also induced by an accident (Zhang et al 1990), very low temperature (Fayemi et al 1992), cryptorchism (Pinart et al …”

mentioning

confidence: 99%

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Antisperm Antibodies in Blood Sera of Bulls and Correlations with Age, Breed and Ejaculate Quality

Zralý¹,

Bendová²,

Diblíková³

et al. 2002

Acta Vet. Brno

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Blood sera from 612 bulls of different age and breed randomly selected in artificial insemination stations and bull rearing stations were examined by ELISA for the presence of antisperm antibodies. At serum dilution 1:40 and higher, the incidence of positive bulls was 35.5%. The first incidence of antibodies was recorded at the age of 5 to 6 months (13.8%), with a significant increase (58.1%; p < 0.01) at 9 to 10 months of age. In the group of bulls aged 5 months and older, positive antibody titres were detected in 42.7% of animals. The finding of antisperm antibodies was significantly higher in active donors of semen compared with the candidate breeders that have not been used as regular donors (56.4% vs. 39.2%; p < 0.01). Higher frequency of antibodies was detected in bulls of the Black Pied Holstein cattle and their crossbreeds compared with the Czech Red Pied cattle and their crossbreeds (48.4% vs. 35.2%; p < 0.01). In positive bulls with a regular semen collection, a lower ejaculate volume was found (p < 0.01) as well as lower activity of endogenous reductases in sperms (p < 0.01) and decreased sperm velocity after 120 min of heat test (p < 0.05). Fertility in those bulls was insignificantly lower. Prognostic and clinical importance of antisperm antibodies for quality assessment of breeding animals is being discussed. Cattle, testis, sperm, spermatoanalysis, autoantibodies, enzyme like immunoassay, fertilityThe development and functions of the reproductive system are controlled by complex neuroendocrine mechanisms. The immune system plays a key role under physiological conditions and in reproductive disorders. The processes leading to sperm formation have some immunologic "privileges". Sperms and their precursors exhibit quite strong antigenic traits. A wide spectrum of antigenic structures is being expressed in the testis during spermatogenesis towards which, ontogenetically, autotolerance mechanisms are inactive. Protection against autoimmunity is provided by the hemotesticular barrier composed predominantly of Sertoli cells isolating the tubular content from the vasculature, and limited lymphatic drainage of the testis. Several other immunoregulatory mechanisms also play a role, e.g. immunosuppressive factors of seminal plasma and both systemic nonspecific and specific factors (immunoregulation cells, cytokines etc.). However, the "isolation" of the sperm antigens is not complete. In the testicular interstitium the cells of the immune system are present, especially macrophages and T lymphocytes. These provide local protection against infection and some other functions, including the supply of growth factors to Leydig cells and precursors of germ cells.The formation of antisperm antibodies (ASA) and their relation to reproduction belong to so far unresolved questions in the field of reproduction. Generally, ASA formation can be induced primarily during infectious and noninfectious inflammations, or by obstruction of testicular efferent duct. The incidence of ASA was also induced by an accident (Zhang et a...

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 83%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Antisperm Antibodies in Blood Sera of Bulls and Correlations with Age, Breed and Ejaculate Quality

Zralý¹,

Bendová²,

Diblíková³

et al. 2002

Acta Vet. Brno

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“…Anti-sperm antibodies occur spontaneously in humans and different species of animals [29][30][31][32] and can be associated with infertility [33][34][35]. Parenteral immunization of female brushtail possums with whole sperm reduced the pregnancy rate up to 80%, through the formation of ASAs in the serum and vaginal secretions [17].…”

Section: Discussionmentioning

confidence: 99%

The detection of canine anti-sperm antibody following parenteral immunization of bitches against homogenized whole sperm

Esmailnejad

Nikahval

Mogheiseh

et al. 2020

Basic Clin. Androl.

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Backgrounds: The development of a canine-specific method of immunocontraception is one of the non-invasive controlling strategies for humanely decreasing the dog population. This study was aimed to investigate the potential of whole sperm in stimulating the immune system and producing specific anti-sperm antibodies (ASAs) in female dogs. Mature, mixed-breed bitches were subcutaneously immunized with high (200 × 10 6 cells/mL) and low (100 × 10 6 cells/mL) doses of sperm vaccine, emulsified with Freund's adjuvants. Booster immunizations were given at weeks 1, 2, 4, and 6, and serum samples were collected at days 0, 14, 28, 42, 63, and 84 prior to each immunization. Reproductive tract samples, including vaginal and uterine lavages, were also collected by flushing each section with sterile PBS at the end of the experiment. Canine anti-sperm antibody titer and specificity in sera and genital secretions were measured using an enzyme-linked immunosorbent assay technique. Results: Specific anti-sperm antibodies were detected in the serum of both high and low dose groups and were significantly higher than those observed in the controls. A high dose of sperm induced elevated immune responses over the low dose antigen. Immunization with a high dose of sperm increased the level of ASAs in the uterine secretions and vaginal secretions significantly. Higher ASAs were observed to have transduced to the uterine lumen compared to the vagina. Conclusions: Based on the results obtained in this study, parenteral immunization with whole sperm can induce a high level of specific antibodies in the serum and genital secretions of female dogs and the response would be dose-dependent.

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Effect of Α–chymotrypsin and Gelatin Supplementation in Rabbit Semen Extender on Anti-Sperm Antibodys and Fertility

El-Speiy¹,

El-Sawy²,

Sadaka

2015

Egyptian Journal of Rabbit Science

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Seroprevalence of sperm antibody in selected Minnesota swine breeding herds

Cited by 4 publications

References 13 publications

Antisperm Antibodies in Blood Sera of Bulls and Correlations with Age, Breed and Ejaculate Quality

Antisperm Antibodies in Blood Sera of Bulls and Correlations with Age, Breed and Ejaculate Quality

The detection of canine anti-sperm antibody following parenteral immunization of bitches against homogenized whole sperm

Effect of Α–chymotrypsin and Gelatin Supplementation in Rabbit Semen Extender on Anti-Sperm Antibodys and Fertility

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