Seroprevalence of TORCH infection and adverse reproductive outcome in women with bad obstretic history

Makhijani, Shrishti; Raut, Sharmila

doi:10.18231/j.ijogr.2021.009

Cited by 2 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bad obstetric history (BOH) can be caused due to genetic, hormonal, abnormal maternal immune response and maternal infections [8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Study to Evaluate Association of Torch Infection with Bad Obstetric History in Pregnant Women at Sms Medical College and Attached Group of Hospitals, Jaipur

Panwar

Bithu

Yadav

et al. 2021

AJMAH

View full text Add to dashboard Cite

Background: Congenital infections are transmissible in utero and it can lead to serious foetal outcomes. These infections can be early detected in pregnant women with bad obstetric history for better foetal outcomes. Aim of the Study was to evaluate the association of TORCH infection with bad obstetric history among pregnant women. Study Design: Observational and comparative study Place and Duration of Study: Central laboratory, Department of Microbiology, SMS Medical College, Jaipur between April 2020 and September 2021. Methodology: 260 blood samples of pregnant women (130 with bad obstetric history and 130 pregnant women without bad obstetric history) were collected. and tested for the presence of IgM and IgG antibodies against Toxoplasma gondii, Rubella virus, Cytomegalovirus by Chemiluminescence and Herpes simplex virus using ELISA kits. Results: Overall TORCH IgM seropositivity in high-risk pregnant women was 17.19%. In pregnant women with bad obstetric history, IgM Seropositivity for Toxoplasma gondii was 3.84% (P value .02), rubella 2.34% (P value .30), Cytomegalovirus 5.47% (P value .08), and 6.25% (P value .56) for Herpes-1 and 2 infections and IgG seropositivity for toxoplasma, rubella, cytomegalovirus and herpes virus was 16.41% (P value .001), 93.75% (P value .11), 98.44% (P value .55), 48.44% (P value .53) respectively. In pregnant women without bad obstetric history, IgM and IgG seropositivity for toxoplasma, rubella, cytomegalovirus and herpes virus was 0/0.77%, 0.76/97.69%, 1.53/99.23% and 4.61/44.62% respectively. The average age of the study population was 27.13 years. Conclusion: As TORCH infections are transmissible in-utero in all the stages of pregnancy and contributes in neonatal and infant deaths, so early diagnosis and appropriate interventions necessary which help in proper management of the pregnant women.

show abstract

“…Bad obstetric history (BOH) can be caused due to genetic, hormonal, abnormal maternal immune response and maternal infections [8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Study to Evaluate Association of Torch Infection with Bad Obstetric History in Pregnant Women at Sms Medical College and Attached Group of Hospitals, Jaipur

Panwar

Bithu

Yadav

et al. 2021

AJMAH

View full text Add to dashboard Cite

show abstract

Antenatal Seropositivity to Toxoplasma, Rubella, Cytomegalovirus, Herpes Simplex Virus - 2 in Bad Obstetric History

Babu¹,

Shamsundar²

2022

jemds

View full text Add to dashboard Cite

BACKGROUND We wanted to evaluate seropositivity of IgM specific antibodies to toxoplasma, rubella, cytomegalovirus and herpes simplex virus 2 in antenatal women with bad obstetric history (BOH). METHODS It was a prospective study with subjects in two groups, study and a control group. Antenatal women with bad obstetric history were considered as a study group in which 70 subjects were included and 20 cases of antenatal women without BOH were in the control group. After informed consent, detailed history was noted in the proforma and 5 ml blood was collected aseptically in a vacutainer and serum was separated and subjected for demonstration of IgM antibody detection towards toxoplasma, rubella, cytomegalovirus and herpes simplex virus 2 was detected by ELISA using the commercial kit as per manufacturers’ direction. RESULTS A total of 90 samples were tested. Study group of seventy (70) samples and control group of 20 from antenatal women. BOH history among the study group common was repeated abortion alone or in combination with others followed by intrauterine death alone or in combination. In the study group, IgM seropositivity was observed as follows with toxoplasma in 1(1.43 %), HSV2 in 4 (5.71 %) and equivocal in 7.14 %. No antibody was detected towards rubella and CMV. The control group showed IgM seropositivity of 5 % each for CMV and HSV-2 and equivocal results were noted in 10 % of cases for HSV-2. Seropositivity towards the pathogens was mainly observed in the younger age group of 21-25 years, HSV-2 seropositivity was observed in 18-20 years of age. The seropositivity to Toxoplasma was observed in the second trimester (13-24 weeks) and HSV-2 in the third trimester (25 to 36 + weeks). CONCLUSIONS All antenatal women with BOH should be routinely screened for TORCH infections so that early diagnosis and appropriate intervention will help in the proper management of these cases. KEY WORDS TORCH Infections; Bad Obstetric History (BOH); IgM Specific ELISA

show abstract

Seroprevalence of TORCH infection and adverse reproductive outcome in women with bad obstretic history

Cited by 2 publications

References 10 publications

Study to Evaluate Association of Torch Infection with Bad Obstetric History in Pregnant Women at Sms Medical College and Attached Group of Hospitals, Jaipur

Study to Evaluate Association of Torch Infection with Bad Obstetric History in Pregnant Women at Sms Medical College and Attached Group of Hospitals, Jaipur

Antenatal Seropositivity to Toxoplasma, Rubella, Cytomegalovirus, Herpes Simplex Virus - 2 in Bad Obstetric History

Contact Info

Product

Resources

About