Seroprevalence of Toxoplasma gondii in the Iranian general population: A systematic review and meta-analysis

Daryani, Ahmad; Sarvi, Shahabeddin; Aarabi, Mohsen; Mizani, Azadeh; Ahmadpour, Ehsan; Shokri, Azar; Rahimi, Mohammad Taghi; Sharif, Mehdi

doi:10.1016/j.actatropica.2014.05.015

Cited by 198 publications

(218 citation statements)

References 37 publications

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“…It spreads with maximum and minimum seropositivity for serum anti Toxoplasma IgG with 70% in northern and 15% in southeastern regions of Iran, determined using the ELISA technique, respectively. This is about 45% in Isfahan city Iran (15). Isfahan has been the most important location for zoonotic CL in Iran.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Toxoplasma gondii Infection in Cutaneous Leishmaniasis Patients of the Isfahan Province

et al. 2016

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Background: Toxoplasma gondii, the etiologic agent of toxoplasmosis, is the most prevalent protozoan parasite in the world. Objectives: Due to high prevalence of toxoplasmosis as well zoonotic cutaneous leishmaniasis with Leishmania major origin in Isfahan, the main objective of this study was to determine, whether there is any correlation between these two protozoan infections and the intensity of the high prevalence of co-infection. Methods: All the case and control samples (80 individuals), collected from suspected patients that had referred for a skin test to the Isfahan dermatology and Leishmaniasis research center from August to November 2014, were investigated. About 2 mL of venipuncture blood was taken from each case and control group member, and serum was separated and stored at -20°C until the enzyme linked immunosorbent assay (ELISA) for detection of anti-Toxoplasma gondii specific IgM and IgG antibodies. Results: Overall, 27 (33.8%) candidates in the control group and 33 (41.3%) patients with Cutaneous Leishmaniasis (CL) were positive for Toxo-IgG. All samples were found to be Toxo-IgM negative. The prevalence difference of Toxoplasma infection in healthy controls and CL patients was not significant. Conclusions:The results of the present study showed that the prevalence difference of Toxoplasma infection in healthy controls and CL patients was not significant. This means, there was no relationship between infection with CL and toxoplasmosis, thus infection with Toxoplasma gondii wasn't a risk factor for infection with Leishmaniasis; Toxoplasma gondii didn't show a preventive or inhibitory role against Leishmania infection.

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Section: Discussionmentioning

confidence: 99%

Investigation of Toxoplasma gondii Infection in Cutaneous Leishmaniasis Patients of the Isfahan Province

et al. 2016

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“…Based on the results of the present study, the prevalence of T. gondii infection in the studied population is close to that found in reports from nearby regions (12); however, the prevalence in other parts of the country has been reported to range from 12% to 86%. The prevalence of toxoplasmosis is higher in the humid regions of northern Iran (8). A very small proportion (0.74%) of the studied population tested positive solely for anti-Toxoplasma IgM, which indicates an acute infection, although 83 (1.29%) subjects tested positive for both IgM and IgG, which can be either an acute or a newly switched chronic infection.…”

Section: Discussionmentioning

confidence: 99%

“…gondii is one of the main concerns during pregnancy, as well as in patients with an impaired immune system and those undergoing immunosuppressive therapy. Infection with T. gondii occurs worldwide, yet a higher prevalence is observed in temperate zones (8). In the present study, a fairly large number of people referred to the Central Laboratory, Tabriz University of Medical Sciences, Tabriz, Iran, were studied over 11 months.…”

Section: Discussionmentioning

confidence: 99%

Study of Anti-Toxoplasma IgG and IgM Seropositivity Among Subjects Referred to the Central Laboratory in Tabriz, Iran, 2013 - 2014

Fatollahzadeh¹,

Jafari²,

Mohammadi³

et al. 2016

Avicenna J Clin Microbiol Infect

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Background: Toxoplasmosis is one of the most widespread parasitic infections worldwide. The infection is mostly benign, although severe disease can be expected in immunocompromised/suppressed individuals and infants who are infected during pregnancy. Objectives: The aim of the present study was to determine the anti-Toxoplasma IgG and IgM seroprevalence in subjects who were referred to the Central Laboratory in Tabriz, Iran, for the diagnosis of toxoplasmosis. Methods: This retrospective cross-sectional study was carried out among 6393 individuals who were referred to the central laboratory, Tabriz University of Medical Sciences, Tabriz, Iran, from March 2013 to January 2014. The subjects were referred from different areas of East Azerbaijan province. The quantitative determination of anti-Toxoplasma IgG and IgM was performed using an antibody capture chemiluminescence immunoassay. The other available variables, including sex and age, were also recorded and analyzed. Results: In total, 1910 (29.87%) out of 6393 subjects were found to be infected with Toxoplasma gondii. In terms of the seropositivity, 1871 (32.42%) out of 5770 and 128 (2.14%) out of 5965 subjects were anti-Toxoplasma IgG and IgM seropositive, respectively. In addition, 103 (1.69%) out of 5828 subjects were equivocal with regard to anti-Toxoplasma IgM, while 57 (0.97%) out of 6068 individuals were equivocal with regard to anti-Toxoplasma IgG. The mean concentration of anti-Toxoplasma IgM was observed to be higher in male subjects than in females (P = 0.016). Conclusions: Based on the findings of the present study, the frequency of Toxoplasma infection is high in the studied population, although it is fairly close to the findings of reports from the other areas of Iran.

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“…The researchers aimed to determine the seroprevalence of T. gondii in 3 age groups (10 to 12, 13 to 15, and 16 to 18) and both genders of Iranian adolescents; as the estimated prevalence was 40% (21), the researchers needed a sample size of about 900 to obtain a 95% confidence interval and 10% precision in the reported prevalence. A total of 900 residual serum samples of CASPIAN III from 16 provinces were selected randomly and were used in this study along with their questionnaires.…”

Section: Patients and Settingmentioning

confidence: 99%

Prevalence of Anti-Toxoplasma gondii Antibodies in Young Iranians: The CASPIAN III Study

Gharavi

Roozbehani

Miahipour

et al. 2017

Arch Pediatr Infect Dis

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Background: Toxoplasmosis is a worldwide neglected tropical and sub-tropical infection caused by Toxoplasma gondii (T. gondii).Most of the previous studies on the seroprevalence of T. gondii in Iran have been done at provincial level and on specific populations, including pregnant females. Socioeconomic parameters are associated with the prevalence of this disease. In this study, the authors evaluated the presence of anti-T. gondii antibodies and the related risk factors in Iranian adolescents.

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Seroprevalence of Toxoplasma gondii in the Iranian general population: A systematic review and meta-analysis

Cited by 198 publications

References 37 publications

Investigation of Toxoplasma gondii Infection in Cutaneous Leishmaniasis Patients of the Isfahan Province

Investigation of Toxoplasma gondii Infection in Cutaneous Leishmaniasis Patients of the Isfahan Province

Study of Anti-Toxoplasma IgG and IgM Seropositivity Among Subjects Referred to the Central Laboratory in Tabriz, Iran, 2013 - 2014

Prevalence of Anti-Toxoplasma gondii Antibodies in Young Iranians: The CASPIAN III Study

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