Seroprevalence survey of measles, rubella, varicella, and mumps antibodies in health care workers and evaluation of a vaccination program in a tertiary care hospital in Japan

Asari, Seishi; Deguchi, Masashi; Tahara, Kazuko; Taniike, Masako; Toyokawa, Masahiro; Nishi, Isao; Watanabe, Mikio; Iwatani, Yoshinori; Makimoto, Kiyoko

doi:10.1067/mic.2003.16

Cited by 49 publications

(26 citation statements)

References 7 publications

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“…In the same way as newly hired HCP, immunity against measles, mumps, rubella, varicella is not reliable in previously hired HCP, especially those who were born before 1990, therefore, in this study, we carried out a prevaccination antibody screening on all previously hired HCP, and conducted a vaccination program for antibody-negative subjects. The prevaccination antibody screening in our study conducted between 2012 and 2013 revealed that the seroprevalence of measles, rubella and varicella was virtually the same as previous Japanese studies in the early first decade of the 2000s (Asari et al 2003;Hatakeyama et al 2004); and after vaccination, the antibody prevalence for measles, rubella and varicella among previously hired HCP reached levels as high as approximately 98%. However, in this study, the prevaccination seroprevalence of mumps was as low as 60% or lower, whereas the antibody prevalence for mumps in previously hired HCP increased successfully to about 80% after vaccination.…”

Section: Discussionmentioning

confidence: 54%

Prevaccination Antibody Screening and Immunization Program for Healthcare Personnel against Measles, Mumps, Rubella, and Varicella in a Japanese Tertiary Care Hospital

Kanamori

Tokuda

Ikeda

et al. 2014

Tohoku J. Exp. Med.

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Susceptible healthcare personnel (HCP) are at high risk for acquiring and transmitting measles, mumps, rubella, and varicella (MMRV). Presumptive evidence of immunity to MMRV is recommended for HCP. The aim of this investigation was to examine the seroprevalence of MMRV in Japanese HCP and the association with history or vaccination in terms of occupational safety. To improve infection control at our hospital, we also assessed their immune status by implementing prevaccination antibody screening and an immunization program with postvaccination serological testing. We implemented seroprevalence surveys on MMRV antibodies among 243 newly and 2,664 previously hired HCP in a Japanese tertiary care hospital. Self-administered questionnaires about history of MMRV and vaccination with or without written documentation were completed for newly hired HCP. Prevaccination and postvaccination serological tests were performed using virus-specific IgG enzyme-linked immunosorbent assays. Indeed, only a few HCP accurately remembered or had written records of their disease or vaccination history. After our immunization program was implemented, the seropositivity rate reached levels as high as ~98% for measles, rubella, and varicella, and increased to ~80% for mumps. Our program was cost-effective, and no severe adverse reactions were reported. The prevaccination antibody screening for HCP would be helpful, given the lack of written vaccination records or documented disease history, and is also useful for the prevention of adverse reactions associated with unnecessary vaccination. It is important for infection control practitioners to comprehend the immune status of HCP against MMRV, and then provide an appropriate immunization program for susceptible HCP.

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Section: Discussionmentioning

confidence: 54%

Prevaccination Antibody Screening and Immunization Program for Healthcare Personnel against Measles, Mumps, Rubella, and Varicella in a Japanese Tertiary Care Hospital

Kanamori

Tokuda

Ikeda

et al. 2014

Tohoku J. Exp. Med.

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“…Asari et al 8 measured antibody titers to measles, rubella, mumps, and varicella viruses in new medical residents and nurses at Osaka University Hospital. Vaccines were given to seronegative subjects and the program subsequently evaluated.…”

Section: Discussionmentioning

confidence: 99%

Susceptibility of medical students to vaccine-preventable viral diseases: a serological study

Kukino

Naito

Mitsuhashi

et al. 2004

Journal of Infection and Chemotherapy

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“…24 A study in a Brazilian university hospital found that the prevalence of one dose of MMR or a history of disease confirmed by serology was 62.5% in residents in the final year of pediatrics. 20 In Japan, in a study performed in 2001, 21 95.9% of physicians and nurses had rubella antibodies, but in a more recent study 25 the prevalence was 89.5%. In Australia, antibodies to measles, mumps, and rubella were found in 89-94% of participating HCW.…”

Section: Discussionmentioning

confidence: 99%

Are healthcare workers immune to rubella?

Borràs

Campins

Esteve

et al. 2013

Human Vaccines & Immunotherapeutics

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Seroprevalence survey of measles, rubella, varicella, and mumps antibodies in health care workers and evaluation of a vaccination program in a tertiary care hospital in Japan

Cited by 49 publications

References 7 publications

Prevaccination Antibody Screening and Immunization Program for Healthcare Personnel against Measles, Mumps, Rubella, and Varicella in a Japanese Tertiary Care Hospital

Prevaccination Antibody Screening and Immunization Program for Healthcare Personnel against Measles, Mumps, Rubella, and Varicella in a Japanese Tertiary Care Hospital

Susceptibility of medical students to vaccine-preventable viral diseases: a serological study

Are healthcare workers immune to rubella?

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