Seroprevalence to cytomegalovirus in the Portuguese population, 2002-2003

Lopo, Sílvia; Vinagre, Elsa; Palminha, Paula; Paixão, Maria Teresa; Nogueira, Paulo; Freitas, Maria Graça

doi:10.2807/ese.16.25.19896-en

Cited by 44 publications

(10 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The CMV transmission variation in different age groups could be due to fact that as the women interaction and encounter with the risk factors tend to increase or decrease according to age [72] and social characters. Our finding was in consistent to that reported for other geographical areas [20], [47], [72], [73], [74]. Seroprevalence for CMV between the age of 15 to 19 years was too high (95.6%).…”

supporting

confidence: 91%

“…The antibody prevalence reduced (94.6%) in the age group of 20 -29 years. This finding was not agreed to that reported for USA, in which seroprevalence increased steadily with age [78], but agreed with that reported for Portugal [74]. Studies with similar age groups conducted in other countries, such as USA, Japan, France, England, Poland, and Russia, describe seroprevalences ranging between 51.5% and 78% [40], [79]- [84].…”

contrasting

confidence: 68%

See 1 more Smart Citation

Association Between Cytomegalovirus Infection and Bad Obstetric Outcomes in Women from Kirkuk

Hassan

Alsamarai

Aljumaili

et al. 2014

IJPHS

View full text Add to dashboard Cite

The human cytomegalovirus (CMV) is one of the common viral infections worldwide that represent a major causes of congenital infections. To determine the seroprevalence of CMV in women with bad obstetric history and sociodemographic characteristics that may influence the seropositivity, a case control descriptive prospective study was conducted in Kirkuk, Iraq. A 838 women with age range from 14 to 48 were included in the study. Of the total, 547 women were with bad obstetric history(BOH) and 291 women with normal previous pregnancy as control group. All the serum samples collected from the study and control groups were tested for CMV IgM and IgG antibodies by ELISA kits. CMV IgM seroprevalence was higher in women with BOH. CMV IgG seroprevalence was with no significant difference between BOH and control. CMV IgG seroprevalence significantly influenced by age, education, smoking, and family size. However, CMV IgM seroprevalence significantly associated with pregnancy, residence, and animal exposure. Odd ratio confirmed the association between CMV IgG and age, crowding index, residence, smoking, and number of abortion in women with BOH. In addition, current CMV infection significantly associated with residence in women with BOH.

show abstract

supporting

confidence: 91%

contrasting

confidence: 68%

Association Between Cytomegalovirus Infection and Bad Obstetric Outcomes in Women from Kirkuk

Hassan

Alsamarai

Aljumaili

et al. 2014

IJPHS

View full text Add to dashboard Cite

show abstract

“…Based on the literature, CMV has the capacity to maintain a long-standing latency state within the host. It should be emphasized that the prevalence of CMV infection is higher and that its infection rates increase with age, reaching up to 95% in older adults (33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

Better Response to Influenza Virus Vaccination in Physically Trained Older Adults Is Associated With Reductions of Cytomegalovirus-Specific Immunoglobulins as Well as Improvements in the Inflammatory and CD8+ T-Cell Profiles

et al. 2021

View full text Add to dashboard Cite

Chronic cytomegalovirus (CMV) infection is a trigger factor for the development of immunosenescence and negatively impacts the immune response to influenza virus vaccination (IVV) in older adults. However, the role of physical exercise training in this context is unknown. Thus, the aim of this study was to investigate whether the regular practice of combined exercise training can improve the specific antibody response to IVV in CMV-seropositive older adults. Eighty older adults were distributed into two groups—non-practitioners (NP, n = 31, age = 74.06 ± 6.4 years) and practitioners of combined exercise training (CET, n = 49, age = 71.7 ± 5.8 years)—for at least 12 months. Both volunteer groups were submitted to IVV and blood samples were collected before (pre) and 30 days after (post) the vaccination. Concerning the specific antibody response to IVV, higher serum levels of specific immunoglobulin A (IgA) were found in the CET group post- than pre-vaccination (p < 0.01), whereas higher levels of specific immunoglobulin M (IgM) were observed both in the NP (p < 0.05) and CET (p < 0.001) groups post-vaccination as compared to the pre-vaccination values. Serum levels of specific immunoglobulin G (IgG) for IVV and CMV, as well as interleukin 6 (IL-6) and IL-10, were similar between the time points evaluated. However, the IL-10/IL-6 ratio post-vaccination was higher (p < 0.05) in the CET group than that before vaccination. Negative correlations were observed between the specific IgG levels for IVV and CMV only in the CET group, both pre- and post-vaccination. In addition, negative correlations were found between IL-10 and specific IgG for CMV in all volunteer groups pre- and post-vaccination, whereas a positive correlation between IL-10 and specific-IgG for IVV pre- and post-vaccination was observed in the CET group. In addition, with the hemagglutination inhibition (HAI) assay, it was found that 32.2% of the NP group and 32.6% of the CET group were responders to IVV and displayed reductions in the CMV serostatus (p < 0.05 and p < 0.001, respectively) and increases in naive and effector CD8+ T cells post-vaccination (p < 0.01). However, only the responders from the CET group showed significant reductions in the ratio of effector to naive CD8+ T cells (p < 0.05) and increased IL-10 levels post-vaccination (p < 0.001). In summary, this study demonstrates that the improvement in the response to IVV in CMV-seropositive older adults was related to an anti-inflammatory status and enhancement of naive CD8+ T cells, particularly associated with regular practice of CET.

show abstract

“…[8] Developed countries show lower prevalence of CMV infection in pregnant women, as seen in studies conducted in Portugal (2001Portugal ( -2002 and Germany (1996-2010, 42.3%). [9,10] Globally, prevalence of HSV antibodies is generally lower than CMV prevalence, especially for HSV type 2, <33%, [11,12] whereas for HSV-1, values <65% are described in the general population. [11,13] In this study, serological screening was performed using a commercial kit that detects antibodies to both viruses (HSV-1 and -2), which may explain the higher percentage of seropositivity than in previous reports.…”

Section: Original Researchmentioning

confidence: 99%

Cytomegalovirus and Herpes Simplex Infections in Mothers and Newborns in a Havana Maternity Hospital

2015

MEDICC Review

View full text Add to dashboard Cite

INTRODUCTION Cytomegalovirus and herpes simplex virus are associated with congenital or perinatal infection, causing potential damage to the newborn.OBJECTIVES Determine the prevalence of active or latent infection by cytomegalovirus and herpes simplex virus in a population of mothers, congenital infection by these agents in their infants, and association between prevalence of virus infection in mothers and in their newborns.METHODS A cross-sectional study was conducted from June to September 2012 in a population of 95 pregnant women admitted to the Dr Ramón González Coro University Maternity Hospital during the third trimester of pregnancy, and their infants (98). Patients were tested for antibodies specifi c to these viruses; vaginal swabs and urine from the women and serum and urine from the newborns were tested for viral genome. The Fisher exact test with 95% confi dence interval was used for comparisons. RESULTSOf the women studied, 89.5% tested positive for cytomegalovirus and 83.2% for herpes simplex. Active infection from cytomegalovirus was detected in 16.7%, and from herpes simplex in 3.2%. Congenital cytomegalovirus infection was detected in 4.1% of newborns; no herpes simplex virus infection was found in this group. Two newborns of women with active cytomegalovirus infection were congenitally infected.CONCLUSIONS Serology demonstrated that most of the women were immune to both viruses. Active cytomegalovirus infections are common in this population, and newborns of women with active cytomegalovirus infection during pregnancy are at increased risk of congenital infection.

show abstract

Seroprevalence to cytomegalovirus in the Portuguese population, 2002-2003

Abstract: Binary file ES_Abstracts_Final_ECDC.txt matches

Cited by 44 publications

References 68 publications

Association Between Cytomegalovirus Infection and Bad Obstetric Outcomes in Women from Kirkuk

Association Between Cytomegalovirus Infection and Bad Obstetric Outcomes in Women from Kirkuk

Better Response to Influenza Virus Vaccination in Physically Trained Older Adults Is Associated With Reductions of Cytomegalovirus-Specific Immunoglobulins as Well as Improvements in the Inflammatory and CD8+ T-Cell Profiles

Cytomegalovirus and Herpes Simplex Infections in Mothers and Newborns in a Havana Maternity Hospital

Contact Info

Product

Resources

About