Seroprevalences of antibodies against pertussis, diphtheria, tetanus, measles, mumps and rubella: A cross-sectional study in children following vaccination procedure in Guangzhou, China

Li, Yating; Luo, Xiang-Qin; Zhong, Xiao-Bing; Cai, Liang‐Ming; Zhu, Liming; Chen, Xiaoqian; Wang, Kun-Cheng; Chen, Zhuang‐Gui

doi:10.1016/j.vaccine.2020.03.056

Cited by 6 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pertussis toxin (PT) is a specific antigen of B. pertussis, and anti-PT IgG antibodies are generally used as serological measures for recent infections or immune response after vaccinations [5] , [8] . The overall GMCs of anti-PT antibodies among infants and children in our study were slightly higher than those reported in previous studies in other regions of China [8] , [10] , [11] , [12] , [14] . Studies conducted in central [14] and southwestern China [12] showed that the levels of anti-PT IgG antibodies remained low throughout all age groups, and there were no obvious immune responses after primary vaccination and booster.…”

Section: Discussioncontrasting

confidence: 87%

“…Pertussis toxin (PT), filamentous hemagglutinin (FHA), and pertactin (PRN) are the key virulence factors of Bordetella pertussis, playing an important role in the induction of clinical immunity [7] , and thus to be the main components of many acellular pertussis vaccines. Several studies have reported the seroprevalence of anti-PT IgG in China [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , but until now, only one study has evaluated anti-FHA IgG [14] and none have evaluated anti-PRN IgG. A previous study carried out in six counties of Zhejiang Province in 2014 reported anti-PT IgG levels among the general population but without data of anti-FHA and anti-PRN [20] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The decline in immunity and circulation of pertussis among Chinese population during the COVID-19 pandemic: A cross-sectional sero-epidemiological study

Zhu²,

Jin³

et al. 2022

Vaccine

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

The decline in immunity and circulation of pertussis among Chinese population during the COVID-19 pandemic: A cross-sectional sero-epidemiological study

Zhu²,

Jin³

et al. 2022

Vaccine

View full text Add to dashboard Cite

“…34 Supplementary vaccination could be considered for children aged 10–15 years to improve protection against mumps and reduce the risk of complications. 35 Development of new vaccines against additional MuV genotypes should also be considered.…”

Section: Discussionmentioning

confidence: 99%

Mumps serological surveillance following 10 years of a one-dose mumps-containing-vaccine policy in Fujian Province, China

Liu¹,

Zhang²,

You

et al. 2022

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

Background Since 2008, Fujian province provided measles-rubella (MR) vaccine at 8 months followed by measles-mumps-rubella (MMR) vaccine at 18 months a one-dose mumps-containing-vaccine (MuCV) schedule. Several mumps outbreaks have occurred recently in Fujian. Serological surveillance can assess population immunity to mumps and identify risk factors for mumps. Methods We conducted a cross-sectional serosurvey of mumps IgG antibodies in the general population of Fujian Province in 2018 and compare results with a similar study conducted in 2009, when the routine schedule had no MuCV. We analyzed changes in mumps epidemiology after implementation of a one-dose MuCV vaccination strategy. Results Mumps seroprevalence was 78.6% (95% CI: 77.4–79.8), and the geometric mean concentration (GMC) of mumps antibodies was 245.8 IU/ml (95% CI:237.3–255.1). MuCV vaccination at 18 months resulted in increased seroprevalence and GMCs. Seroprevalence and GMCs varied by age, gender, and number of doses received. Except for children under 18 months, seroprevalence and GMCs were lowest among 10-15-year-olds. Each year after introduction of the one-dose MuCV vaccination policy, the highest incidence of mumps was among 4–6-year-olds and 9–15-year-olds, gradually shifting to older age groups. Conclusion A one-dose mumps-containing vaccine schedule does not provide sustained and stable mumps immunity in Fujian. To reduce the risk of mumps, we recommend supplementary vaccination of children without a history of receiving at least one MuCV dose or who are seronegative at 10–15 years of age.

show abstract

“…At present, several countries with a high incidence of pertussis have implemented the strategy of maternal immunizations [28]. However, so far, no booster immunizations in China have been recommended [29].…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence Study of Pertussis in Adults at Childbearing Age and Young Infants Reveals the Necessity of Booster Immunizations in Adults in China

et al. 2022

View full text Add to dashboard Cite

In China, the vaccination strategy against pertussis is started from 3 months of age, with no booster dose used after the booster given at two years. Despite a high vaccination coverage, pertussis has been increasingly reported since the last decade. This study evaluates the prevalence of serum anti-pertussis toxin (PT) IgG antibodies in adults at childbearing age and infants before the age of primary immunization in Beijing, China. A total of 1175 serum samples randomly selected from individuals who attended an annual health examination at the Sixth Medical Center of the PLA General Hospital, Beijing, in 2019, was included. The geometric mean concentration (GMC) and median concentration of anti-PT IgG antibodies among adults aged 20–39 years were 3.81 IU/mL and 3.24 IU/mL, and the corresponding concentrations were 1.72 IU/mL and 1.43 IU/mL among infants under 3 months of age. The seroprevalence of PT IgG antibodies ≥ 40 IU/mL in adults and infants was 2.0% (15/735) and 1.1% (5/440). In total, 65.99% (485/735) of adults and 83.41% (367/440) of infants had non-detectable pertussis-specific antibodies (<5 IU/mL). Our results showed that the majority of adults at a reproductive age and young infants are vulnerable to pertussis, suggesting that booster vaccinations in adults should be considered in this country.

show abstract

Seroprevalences of antibodies against pertussis, diphtheria, tetanus, measles, mumps and rubella: A cross-sectional study in children following vaccination procedure in Guangzhou, China

Cited by 6 publications

References 36 publications

The decline in immunity and circulation of pertussis among Chinese population during the COVID-19 pandemic: A cross-sectional sero-epidemiological study

The decline in immunity and circulation of pertussis among Chinese population during the COVID-19 pandemic: A cross-sectional sero-epidemiological study

Mumps serological surveillance following 10 years of a one-dose mumps-containing-vaccine policy in Fujian Province, China

Seroprevalence Study of Pertussis in Adults at Childbearing Age and Young Infants Reveals the Necessity of Booster Immunizations in Adults in China

Contact Info

Product

Resources

About