Serotonergic innervation of the isthmo-optic nucleus of the pigeon centrifugal visual system. An immunocytochemical electron microscopic study

Rio, J.P.; Repérant, J; Miceli, D.; Médina, Monique; Kenigfest-Rio, N.B

doi:10.1016/s0006-8993(01)03262-0

Cited by 7 publications

(5 citation statements)

References 41 publications

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“…They have been described, without comment, in the corresponding tectal layers of the viper (Rio et al 1995), in the isthmo-optic nucleus of the pigeon Rio et al 2002), the nucleus dorsolateralis anterior of the same species (Miceli et al 2008), and in the nucleus geniculatus lateralis dorsalis of mammals (Papadopoulos and Parnavelas 1990;Pásik et al 1988). In the latter cases it has been shown that they correspond to serotoninergic terminals.…”

Section: At5 Terminalsmentioning

confidence: 99%

Synaptic circuitry in the retinorecipient layers of the optic tectum of the lamprey (Lampetra fluviatilis). A combined hodological, GABA and glutamate immunocytochemical study

et al. 2009

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The ultrastructure of the retinorecipient layers of the lamprey optic tectum was analysed using tract tracing techniques combined with GABA and glutamate immunocytochemistry. Two types of neurons were identified; a population of large GABA-immunonegative cells, and a population of smaller, highly GABA-immunoreactive interneurons, some of whose dendrites contain synaptic vesicles (DCSV). Five types of axon terminals were identified and divided into two major categories. The first of these are GABA-immunonegative, highly glutamate-immunoreactive, contain round synaptic vesicles, make asymmetrical synaptic contacts, and can in turn be divided into AT1 and AT2 terminals. The AT1 terminals are those of the retinotectal projection. The origin of the nonretinal AT2 terminals could not be determined. AT1 and AT2 terminals establish synaptic contacts with DCSV, with dendrites of the retinopetal neurons (DRN), and with conventional dendritic (D) profiles. The terminals of the second category are GABA-immunoreactive and can similarly be divided into AT3 and AT4 terminals. The AT3 terminals contain pleiomorphic synaptic vesicles and make symmetrical synaptic contacts for the most part with glutamate-immunoreactive D profiles. The AT4 terminals contain rounded synaptic vesicles and make asymmetrical synaptic contacts with DRN, with DCSV, and with D profiles. A fifth, rarely observed category of terminals (AT5) contain both clear synaptic vesicles and a large number of dense-core vesicles. Synaptic triads involving AT1, AT2 or AT4 terminals are rare. Our findings are compared to these of previous studies of the fine structure and immunochemical properties of the retinorecipient layers of the optic tectum or superior colliculus of Gnathostomes.

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Section: At5 Terminalsmentioning

confidence: 99%

Synaptic circuitry in the retinorecipient layers of the optic tectum of the lamprey (Lampetra fluviatilis). A combined hodological, GABA and glutamate immunocytochemical study

et al. 2009

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“…Presynaptic terminals of vertebrates and invertebrates store serotonin in conventional clear vescles and in some cases, in large dense core vesicles (Kuffler et al, 1987;Van Bockstaele et al, 1994;Smiley and Goldman-Rakic, 1996;Liem and Copray, 1996;Rio et al, 2002). In addition, dense core vesicles at some serotonergic terminals may contain peptides such as substance P (Dey and Hoffpauir, 1986) and others.…”

Section: Serotonergic Transmission At Synapsesmentioning

confidence: 99%

Synaptic and Extrasynaptic Secretion of Serotonin

2005

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Serotonin is a major modulator of behavior in vertebrates and invertebrates and deficiencies in the serotonergic system account for several behavioral disorders in humans. The small numbers of serotonergic central neurons of vertebrates and invertebrates produce their effects by use of two modes of secretion: from synaptic terminals, acting locally in "hard wired" circuits, and from extrasynaptic axonal and somatodendritic release sites in the absence of postsynaptic targets, producing paracrine effects. In this paper, we review the evidence of synaptic and extrasynaptic release of serotonin and the mechanisms underlying each secretion mode by combining evidence from vertebrates and invertebrates. Particular emphasis is given to somatic secretion of serotonin by central neurons. Most of the mechanisms of serotonin release have been elucidated in cultured synapses made by Retzius neurons from the central nervous system of the leech. Serotonin release from synaptic terminals occurs from clear and dense core vesicles at active zones upon depolarization. In general, synaptic serotonin release is similar to release of acetylcholine in the neuromuscular junction. The soma of Retzius neurons releases serotonin from clusters of dense core vesicles in the absence of active zones. This type of secretion is dependent of the stimulation frequency, on L-type calcium channel activation and on calcium-induced calcium release. The characteristics of somatic secretion of serotonin in Retzius neurons are similar to those of somatic secretion of dopamine and peptides by other neuron types. In general, somatic secretion by neurons is different from transmitter release from clear vesicles at synapses and similar to secretion by excitable endocrine cells.

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“…Even allowing for an underestimate of Tgr1 terminals, it is quite likely that the unlabeled profiles with rounded synaptic vesicles belong to other afferent supplies to the GLd, which have been observed in the turtle under light microscopy, particularly a cholinergic (Kenigfest et al, 2001) or serotoninergic (Ueda et al, 1983; Kenigfest et al, 2001) supply. Electron microscopic studies of the visual systems of birds and mammals have shown that terminals immunolabeled by antibodies directed against these two substances can be described as RSD in Guillery's (1969) terminology (de Lima et al, 1985; de Lima and Singer, 1987; Pásik et al, 1988, 1990; Seguela et al, 1989; Raczkowski and Fitzpatrick, 1989; Papadopoulos and Parnavelas, 1990; Dinopoulos et al, 1995; Erisir et al, 1997; Rio et al, 2002; Sherman and Guillery, 2002), brainstem cholinergic terminals making up roughly one‐half of all RSD in the cat GLd (Erisir et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Pretectal and tectal afferents to the dorsal lateral geniculate nucleus of the turtle: An electron microscopic axon tracing and γ‐aminobutyric acid immunocytochemical study

Кенигфест

Rio

Belekhova

et al. 2004

J of Comparative Neurology

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The pretectal and tectal projections to the dorsal lateral geniculate nucleus (GLd) of two species of turtle (Emys orbicularis and Testudo horsfieldi) were examined under the electron microscope by using axonal tracing techniques (horseradish peroxidase or biotinylated dextran amine) and postembedding gamma-aminobutyric acid (GABA) immunocytochemistry. After injection of tracer into the pretectum, two types of axon terminals were identified as those of pretectogeniculate pathways. Both contained pleomorphic synaptic vesicles and were more numerous in the inner part of the nucleus. They could be distinguished on the bases of size and shape of their synaptic vesicles, type of synaptic contact, and level of GABA immunoreactivity. One type had a higher density of immunolabeling and established symmetric synaptic contacts, whereas the other, less densely immunolabeled, made asymmetric synaptic contacts. In both cases, synaptic contacts were mainly with relay cells and occasionally with interneurons. We suggest that these two types of pretectogeniculate terminals originate in two separate pretectal nuclei. After injection of tracer into the optic tectum, a single population of GABA-immunonegative tracer-labeled terminals was identified as belonging to the tectogeniculate pathway. These were small, had smooth contours, contained very small round synaptic vesicles, and established asymmetric synaptic contacts with long active zones, predominantly with relay cells and less frequently with interneurons, in the inner part of the nucleus. In addition, a population of GABA-negative and occasionally GABA-positive terminals, labeled by tracer injected into either the pretectum or the tectum, was identified as retinal terminals; these were presumably labeled by the retrograde transport of tracer in collateral branches of visual fibers innervating both the GLd and the pretectum or tectum. Comparison of the present ultrastructural findings in turtles with those previously reported in mammals shows that the cytological features, synaptic morphology, and immunochemical properties of the pretectogeniculate and tectogeniculate terminals of both groups share many similarities. Nevertheless, the postsynaptic targets of these two categories of terminals display some pronounced differences between the two groups, which are discussed in terms of their possible functional significance.

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Serotonergic innervation of the isthmo-optic nucleus of the pigeon centrifugal visual system. An immunocytochemical electron microscopic study

Cited by 7 publications

References 41 publications

Synaptic circuitry in the retinorecipient layers of the optic tectum of the lamprey (Lampetra fluviatilis). A combined hodological, GABA and glutamate immunocytochemical study

Synaptic circuitry in the retinorecipient layers of the optic tectum of the lamprey (Lampetra fluviatilis). A combined hodological, GABA and glutamate immunocytochemical study

Synaptic and Extrasynaptic Secretion of Serotonin

Pretectal and tectal afferents to the dorsal lateral geniculate nucleus of the turtle: An electron microscopic axon tracing and γ‐aminobutyric acid immunocytochemical study

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