Serotonergic modulation of feeding behavior in Caenorhabditis elegans and other related nematodes

Ishita, Yuuki; Chihara, Takahiro; Okumura, Misako

doi:10.1016/j.neures.2019.04.006

Cited by 31 publications

(17 citation statements)

References 94 publications

(167 reference statements)

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“…To address this question we decided to look at two sets of muscles; the egg-laying posterior muscles and the pharyngeal muscles. The egg-laying muscles are regulated by multiple neurotransmitters including dopamine [47], while pharyngeal pumping is regulated by serotonin (reviewed in [48]). However, studies have shown that serotonergic behaviors could be modulated by dopamine (reviewed in [49]).…”

Section: Ethanol Exposure Affects Movement In Dop-2 Mutantsmentioning

confidence: 99%

Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans

et al. 2021

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Ethanol is a widely used drug, excessive consumption of which could lead to medical conditions with diverse symptoms. Ethanol abuse causes dysfunction of memory, attention, speech and locomotion across species. Dopamine signaling plays an essential role in ethanol dependent behaviors in animals ranging from C. elegans to humans. We devised an ethanol dependent assay in which mutants in the dopamine autoreceptor, dop-2, displayed a unique sedative locomotory behavior causing the animals to move in circles while dragging the posterior half of their body. Here, we identify the posterior dopaminergic sensory neuron as being essential to modulate this behavior. We further demonstrate that in dop-2 mutants, ethanol exposure increases dopamine secretion and functions in a DVA interneuron dependent manner. DVA releases the neuropeptide NLP-12 that is known to function through cholinergic motor neurons and affect movement. Thus, DOP-2 modulates dopamine levels at the synapse and regulates alcohol induced movement through NLP-12.

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Section: Ethanol Exposure Affects Movement In Dop-2 Mutantsmentioning

confidence: 99%

Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans

et al. 2021

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“…For instance, in Drosophila adults, activating all 5-HT neurons suppresses food intake whereas activating a smaller yet diverse subset promotes food intake, suggesting heterogeneity in 5-HT regulation of feeding (Albin et al, 2015;Pooryasin and Fiala, 2015). With the exception of a few cases where specific 5-HT neurons that influence feeding have been identified -for example, the 5-HT neurons that promote pharyngeal pumping rate to enhance food ingestion in C. elegans and Drosophila larvae (Ishita et al, 2020;Schoofs et al, 2018;Tierney, 2020) -the diversity of 5-HT neurons that contributes to feeding regulation and their influence on nutrient stores remains largely uncharacterized.…”

Section: -Ht Has Multifaceted Roles In Feeding Regulation and Nutrient Homeostasismentioning

confidence: 99%

Serotonergic Neurons Translate Taste Detection into Internal Nutrient Regulation

Zhang

Scott

2021

Preprint

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The nervous and endocrine systems coordinately monitor and regulate nutrient availability to maintain energy homeostasis. Sensory detection of food regulates internal nutrient availability in a manner that anticipates food intake, but sensory pathways that promote anticipatory physiological changes remain unclear. Here, we identify serotonergic (5-HT) neurons as critical mediators that transform gustatory detection by sensory neurons into the activation of insulin-producing cells and enteric neurons in Drosophila. One class of 5-HT neurons responds to gustatory detection of sugars, excites insulin-producing cells and limits consumption, suggesting that they anticipate increased nutrient levels and prevent overconsumption. A second class of 5-HT neurons responds to gustatory detection of bitter compounds and activates enteric neurons to promote gastric motility, likely to stimulate digestion and increase circulating nutrients when food quality is poor. These studies demonstrate that 5-HT neurons relay acute gustatory detection to divergent pathways for longer-term stabilization of circulating nutrients.

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“…We first considered the three classic neurotransmitters ACh, Glu and serotonin which are employed in C. elegans much like in the enteric nervous system of other species: Seven of the 14 pharyngeal neuron classes use acetylcholine as neurotransmitter, four use glutamate and one uses serotonin (NSM) (Horvitz et al, 1982;Pereira et al, 2015;Taylor et al, 2021). Of those neurotransmitters, serotonin is perhaps the best studied neurotransmitter both in the vertebrate enteric nervous system (Gershon, 2013) as well as in the nematode pharyngeal nervous system (Horvitz et al, 1982;Ishita et al, 2020;Song and Avery, 2013).…”

Section: Ceh-34 Controls the Expression Of Diverse Neurotransmitter Signaling Pathways In Pharyngeal Neuronsmentioning

confidence: 99%

The enteric nervous system of C. elegans is specified by the Sine Oculis-like homeobox gene ceh-34

Vidal

Gülez

Cao

et al. 2021

Preprint

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Overarching themes in the terminal differentiation of the enteric nervous system, an autonomously acting unit of animal nervous systems, have so far eluded discovery. We describe here the overall regulatory logic of enteric nervous system differentiation of the nematode C. elegans that resides within the foregut (pharynx) of the worm. A Caenorhabditis elegans homolog of the Drosophila Sine Oculis homeobox gene, ceh-34, is expressed in all 14 classes of interconnected pharyngeal neurons from their birth throughout their life time, but in no other neuron type of the entire animal. Constitutive and temporally controlled ceh-34 removal shows that ceh-34 is required to initiate and maintain the neuron type-specific terminal differentiation program of all pharyngeal neuron classes, including their circuit assembly, without affecting panneuronal features. Through additional genetic loss of function analysis, we show that within each pharyngeal neuron class, ceh-34 cooperates with different homeodomain transcription factors to individuate distinct pharyngeal neuron classes. Our analysis underscores the critical role of homeobox genes in neuronal identity specification and links them to the control of neuronal circuit assembly of the enteric nervous system. Together with the pharyngeal nervous system simplicity as well as its specification by a Sine Oculis homolog, our findings invite speculations about the early evolution of nervous systems.

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Serotonergic modulation of feeding behavior in Caenorhabditis elegans and other related nematodes

Cited by 31 publications

References 94 publications

Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans

Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans

Serotonergic Neurons Translate Taste Detection into Internal Nutrient Regulation

The enteric nervous system of C. elegans is specified by the Sine Oculis-like homeobox gene ceh-34

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