“…5-HT 7 receptor agonists exerted slow depolarizing effects and increased neuronal firing in several brain areas (Figure 1), among which the anterodorsal nucleus of the rat thalamus (Chapin and Andrade, 2001), rat globus pallidus (Chen et al, 2008), mouse hippocampal CA1 region (Bickmeyer et al, 2002) and mouse trigeminal nucleus caudalis (Yang et al, 2014). Activation of 5-HT 7 receptors enhanced the firing rate of rat CA1 pyramidal neurons (Tokarski et al, 2003), CA3 pyramidal neurons (Gill et al, 2002), striatal cholinergic interneurons (Bonsi et al, 2007), prefrontal cortex pyramidal neurons (Zhang, 2003; Béïque et al, 2004a) and nucleus accumbens (NAc) neurons (Ishihara et al, 2013). In a spinal cord slice preparation, 5-HT application induced a locomotor-like rhythmic firing activity of motoneurons in wild type but not in 5-HT 7 KO mice, indicating that the excitability of spinal motoneurons was enhanced by 5-HT 7 receptors (Liu et al, 2009).…”