2020
DOI: 10.1530/joe-19-0546
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Serotonergic regulation of energy metabolism in peripheral tissues

Abstract: Serotonin is a biogenic amine synthesized from the essential amino acid tryptophan. Because serotonin cannot cross the blood-brain barrier, it functions differently in neuronal and non-neuronal tissues. In the CNS, serotonin regulates mood, behavior, appetite, and energy expenditure. Although most serotonin in the body is synthesized at the periphery, its biological roles have not been well elucidated. Older studies using chemical agonists and antagonists yielded conflicting results, because the complexity of … Show more

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Cited by 24 publications
(27 citation statements)
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“…Due to the inverse relationship between brain 5HT bioavailability and food intake, suggested by early pharmacological studies, 5HT was first recognized as an anorexigenic neurotransmitter [1] and enhancement of 5HT functioning was proposed as a potential anti-obesity treatment (reviewed in [2]). In contrast to central 5HT, the role of peripheral 5HT in the regulation of body weight and energy expenditure/metabolism has only recently been extensively studied [3][4][5][6][7].…”
Section: Introductionmentioning
confidence: 99%
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“…Due to the inverse relationship between brain 5HT bioavailability and food intake, suggested by early pharmacological studies, 5HT was first recognized as an anorexigenic neurotransmitter [1] and enhancement of 5HT functioning was proposed as a potential anti-obesity treatment (reviewed in [2]). In contrast to central 5HT, the role of peripheral 5HT in the regulation of body weight and energy expenditure/metabolism has only recently been extensively studied [3][4][5][6][7].…”
Section: Introductionmentioning
confidence: 99%
“…The presence of functional 5HT-related proteins (metabolic enzymes, transporters, and receptors) has been demonstrated in various metabolic organs such as pancreas, liver, bone, and adipose tissue [5,[8][9][10]. Peripheral 5HT, acting either as a gut-derived hormone or in an autocrine/paracrine manner, has been shown to have important regulatory roles in various metabolic tissues [6,7,11]. Accordingly, 5HT has been shown to stimulate adipogenesis [12,13], regulate lipolysis [14,15], promote insulin secretion [16], inhibit glucose production [14], and blunt brown adipose tissue thermogenic activity [5,17].…”
Section: Introductionmentioning
confidence: 99%
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“…Peripheral 5-HT is mainly synthesized by enterochroma n cells in the gut 35 . Once released from the gut, most 5-HT is taken up into platelets (> 95%), and the remaining free 5-HT level in the circulation is very low [36][37][38] . Therefore, plasma 5-HT levels re ect the bioactive free 5-HT, platelet 5-HT levels re ect the major 5-HT pool in the periphery, and serum 5-HT levels re ect both the bioactive 5-HT and 5-HT pools 38,39 .…”
Section: Discussionmentioning
confidence: 99%
“…Obesity is associated with chronic and low-grade inflammation as well as neuronal, endocrine and adipocyte factors that interact in the regulation of food intake and energy storage ( Halpern et al., 2004 ; Guo et al., 2020 ; Zhou et al., 2020 ). Food intake is influenced by gastrointestinal mechanisms involving gastric accommodation and emptying, digestion and absorption of nutrients, mechanisms that are regulated by gut-brain axis and mediated by serotonin (5-hydroxytryptamine [5-HT]) ( Hayes et al., 2004 ; González-Arancibia et al., 2016 ; D'Agostino et al., 2018 ; Choi et al., 2020 ).…”
Section: Introductionmentioning
confidence: 99%