Serotonergic system may be involved in alterations of sleep homeostasis in spontaneously hypertensive rats

Abstract

Evidence from population-based epidemiological studies, experimental sleep deprivation (SD) studies and interventional studies has provided important links between hypertension and sleep disorders (Bruno et al., 2013; Gangwisch, 2014). Hypertension has been shown to be associated with a short sleep duration in both cross-sectional and longitudinal epidemiological studies (Gangwisch, 2014). SD or insufficient sleep can raise blood pressure and lead to structural adaptations that can increase the risk for hypertension (Javaheri,

Protein tyrosine phosphatase receptor type delta (PTPRD) gene in an animal model of restless legs syndrome

“…In the analysis of sleep pattern, we observed that the SHR group showed worse sleep quality than the WK group, especially during the light cycle, corroborating other studies (Esteves et al, 2013; Su‐Ying et al, 2019) where the authors found a significant increase in the percentage of wakefulness in the SHR group. In the present study, we observed this increase only in the light cycle.…”

“…Furthermore, we found that the SHR group showed a significant reduction in TST, SE and SWS (light cycle). Corroborating our study, Su‐Ying et al (2019) also observed lower TST and increased wakefulness (light cycle) in the SHR group compared to WK group (Su‐Ying et al, 2019), and other studies have shown that SHR may have a shorter time of SWS as well as REM sleep, during the light cycle, compared to the dark cycle (Kuo et al, 2004; Su‐Ying et al, 2019).…”

“…Furthermore, we found that the SHR group showed a significant (Kuo et al, 2004;Su-Ying et al, 2019).…”

“…Interestingly, our results showed that the SHR group slept longer during the dark cycle, staying awake longer in the light cycle. Similarly, a study (Su‐Ying et al, 2019) found that SHR exhibited changes in sleep pattern, in which these rats also spent more time awake during the inactive period (light cycle) and slept more during the active period (dark cycle). Furthermore, they also observed that SHR had more interruptions during sleep, resulting in shorter sleep time and poor sleep quality.…”

“…In the present study, we observed this increase only in the light cycle. There was also a significant increase in the number of awakenings (dark cycle), which, like wakefulness, may also be associated with worsening of RLS symptoms, and sleep fragmentation in this syndrome is quite common (Su‐Ying et al, 2019).…”