1998
DOI: 10.1111/j.1600-0447.1998.tb10017.x
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Serotonergic‘vulnerability’ in affective disorder: a study of the tryptophan depletion test and relationships between peripheral and central serotonin indexes in citalopram‐responders

Abstract: A double-blind study of the tryptophan depletion (TD) challenge was performed on a sample consisting of 20 patients with a major depressive disorder in clinical remission after citalopram treatment. TD was induced by the intake of 43 g of an amino acid mixture containing the five large neutral amino acids. The control group received the same mixture, to which 2.3 g tryptophan had been added. Five of the 12 challenged patients showed a worsening of depressive symptoms during the day of the test. In contrast, th… Show more

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Cited by 47 publications
(37 citation statements)
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“…In essence, serotonergic vulnerability (SV) means that there is a vulnerability or sensitivity to alterations or dysregulations in the 5-HTergic system (based upon references 21,[23][24][25][26][27][28][29][30] ). Thus, the idea is that the 5-HTergic functioning of an individual determines the vulnerability of that individual to develop disorders that are related to 5-HT.…”
Section: -Htergic Vulnerabilitymentioning
confidence: 99%
See 2 more Smart Citations
“…In essence, serotonergic vulnerability (SV) means that there is a vulnerability or sensitivity to alterations or dysregulations in the 5-HTergic system (based upon references 21,[23][24][25][26][27][28][29][30] ). Thus, the idea is that the 5-HTergic functioning of an individual determines the vulnerability of that individual to develop disorders that are related to 5-HT.…”
Section: -Htergic Vulnerabilitymentioning
confidence: 99%
“…Mood lowering in response to ATD demonstrates individual vulnerability of the 5-HTergic system. 24,[27][28][29][30]373 In currently depressed untreated patients, ATD does not cause any mood-lowering (for review see Maes and Meltzer, 23 Bell et al, 320 Young and Leyton 321 ). However, ATD can cause mood changes in subjects with a personal history of mood disorders.…”
Section: Depletion/atdmentioning
confidence: 99%
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“…In remitted depressed patients, ATD induced depressive symptoms (Smith et al 1997;Aberg-Wistedt et al 1998;Moreno et al 2000). In healthy first-degree relatives of depressed patients, ATD induced a modest lowering of mood, compared with healthy control subjects (Benkelfat et al 1994;Klaassen et al 1999).…”
Section: -Ht Vulnerability In Relatives Of Bipolar Patients 835mentioning
confidence: 99%
“…No mood measures were reported in that study, but chronically high cortisol has frequently been linked to dysphoric mood and clinical depression (Checkley, 1996), although this might relate to dysfunction of brain 5-HT systems as well as the hypothalamic pituitary adrenal axis (Van Praag, 1996). Indeed, high baseline plasma cortisol predicts induction of depression by acute dietary TRP depletion (Åberg-Wistedt et al 1998). By comparison with acute effects, any understanding of mechanisms underlying chronic effects will need to include neurotransmitter and neurohormone receptor adaptation (Huether et al 1998).…”
Section: Effects Of Chronic Dietary Manipulations On Mood and Performmentioning
confidence: 99%