Serotonin: An ancient molecule and an important regulator of plant processes

Erland, Lauren A. E.; Turi, Christina E.; Saxena, Praveen K.

doi:10.1016/j.biotechadv.2016.10.002

Cited by 75 publications

(93 citation statements)

References 92 publications

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“…This could function as a means of regulating direction of tryptophan to other important biosynthetic pathways such as the indole alkaloids, auxin or towards protein synthesis [17][18][19] . Though the biosynthesis and regulation of serotonin biosynthesis is a well characterized process in vertebrates the study of serotonin biosynthesis and control in plants is still a relatively young field and continues to be an area of active and promising research [20] .…”

Section: Serotonin Biosynthesismentioning

confidence: 99%

“…Since its discovery serotonin has been identified in over 90 species and 37 plant families, with concentrations varying significantly with family, species, cultivar, tissue type, and stage of maturity [20] . Additionally, serotonin in plants has been found to vary widely with environmental factors including light levels and wavelength, abiotic and biotic stress and growth conditions, and location [20,21] .…”

Section: Discovery and Occurrence Of Serotonin In Plantsmentioning

confidence: 99%

“…Additionally, serotonin in plants has been found to vary widely with environmental factors including light levels and wavelength, abiotic and biotic stress and growth conditions, and location [20,21] . For this reason, published values for serotonin content provide guidance as to the serotonin levels of different tissues, plants or samples, but do not represent an absolute standard concentration.…”

Section: Discovery and Occurrence Of Serotonin In Plantsmentioning

confidence: 99%

“…For this reason, published values for serotonin content provide guidance as to the serotonin levels of different tissues, plants or samples, but do not represent an absolute standard concentration. This is of particular importance in considering the stated literature concentrations in medicinal and food crops, which are the most commonly investigated plants for serotonin content [20] . Plant growth conditions and geographical location may also be an important consideration as is the case for melatonin.…”

Section: Discovery and Occurrence Of Serotonin In Plantsmentioning

confidence: 99%

“…Plant growth conditions and geographical location may also be an important consideration as is the case for melatonin. Growth from vegetative cuttings vs seeds or specialized processes such as grafting or in vitro propagation, may also effect the indoleamine content of the tissues [20,22] . Despite this diversity, many studies still provide interesting information as to the relative quantities.…”

Section: Discovery and Occurrence Of Serotonin In Plantsmentioning

confidence: 99%

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Beyond a neurotransmitter: The role of serotonin in plants

Erland

Saxena

2017

Neurotransmitter

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Serotonin is a neurotransmitter than has been identified across all forms of life. In recent years the presence and function of serotonin in plants (phytoserotonin) is becoming an increasingly active area of research. Serotonin has been found to function as a plant growth regulator, and a stress defense molecule. Through these functions serotonin has been implicated in mediation of morphogenesis, vegetative growth, reproductive development, seed germination and survival, abiotic and biotic stress survival and mediation of plant signaling and mediation of plant cycles. Despite its widespread importance in plants there is still very little understood about the mechanism of action of this important signaling molecule in plants, therefore, this review provides a brief overview of the roles and mechanisms of serotonin in the plant system.

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Section: Serotonin Biosynthesismentioning

confidence: 99%

Section: Discovery and Occurrence Of Serotonin In Plantsmentioning

confidence: 99%

Section: Discovery and Occurrence Of Serotonin In Plantsmentioning

confidence: 99%

Section: Discovery and Occurrence Of Serotonin In Plantsmentioning

confidence: 99%

Section: Discovery and Occurrence Of Serotonin In Plantsmentioning

confidence: 99%

See 3 more Smart Citations

Beyond a neurotransmitter: The role of serotonin in plants

Erland

Saxena

2017

Neurotransmitter

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Analysis and measurement of serotonin

Szeitz

Bandiera

2017

Biomedical Chromatography

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Serotonin, also known as 5-hydroxytryptamine, is an important signaling molecule in the central and peripheral nervous systems of humans. Acting through several receptor types, it helps regulate the normal functioning of the gastrointestinal tract, cardiovascular system and brain. Serotonin signaling has also been implicated in the etiology of several diseases, including depression, anxiety disorders, hypertension and irritable bowel syndrome. The present review focuses on the chemical analysis of serotonin in biological fluids and biomatrices and traces the development and application of early methods based on UV absorbance or fluorescence to more widely used current methods such as high-performance liquid chromatography coupled to mass spectrometry.A brief summary of the biochemistry, metabolism and physiological roles of serotonin is also presented.

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Cardiovascular serotonergic system: Evolution, receptors, transporter, and function

Soslau

2021

J Exp Zool Pt A

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The serotonergic system, serotonin (5HT), serotonin transporter (SERT), and serotonin receptors (5HT‐x), is an evolutionarily ancient system that has clear physiological advantages to all life forms from bacteria to humans. This review focuses on the role of platelet/plasma serotonin and the cardiovascular system with minor references to its significant neurotransmitter function. Platelets transport and store virtually all plasma serotonin in dense granules. Stored serotonin is released from activated platelets and can bind to serotonin receptors on platelets and cellular components of the vascular wall to augment aggregation and induce vasoconstriction or vasodilation. The vascular endothelium is critical to the maintenance of cardiovascular homeostasis. While there are numerous ligands, neurological components, and baroreceptors that effect vascular tone it is proposed that serotonin and nitric oxide (an endothelium relaxing factor) are major players in the regulation of systemic blood pressure. Signals not fully defined, to date, that direct serotonin binding to one of the 15 identified 5HT receptors versus the transporter, and the role platelet/plasma serotonin plays in regulating hypertension within the cardiovascular system remain important issues to better understand many diseases and to develop new drugs. Also, expanded research of these pathways in lower life‐forms may serve as important model systems to further our understanding of the evolution and mechanisms of action of serotonin.

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Serotonin: An ancient molecule and an important regulator of plant processes

Cited by 75 publications

References 92 publications

Beyond a neurotransmitter: The role of serotonin in plants

Beyond a neurotransmitter: The role of serotonin in plants

Analysis and measurement of serotonin

Cardiovascular serotonergic system: Evolution, receptors, transporter, and function

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