Serotonin and vascular reactivity

Nueten, J. M. Van; Janssens, W. J.; Vanhoutte, Paul M.

doi:10.1016/0031-6989(85)90067-0

Cited by 97 publications

(56 citation statements)

References 37 publications

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“…The lack of responses to 5-HT may be involved in reactive hyperemia, in which the cerebral blood flow increases transiently following occlusions of the large artery (Zimmer et al, 1971;Hossmann, 1997;Matsubara et al, 1998). In this context, previous physiological studies reported that 5-HT constricted large arteries and reduced the vascular resistance of small vessels (Rapport, 1949, Sjaastad, 1975, Cohen et al, 1983, Van Nueten 1985Van Nueten et al, 1985;Faraci and Heistad, 1990). Another in vivo observation confirmed that 5-HT induced the contraction of the pial vessel (>200 m in resting diameter), whereas it dilated small vessels (< 70 m in diameter) (Harper and MacKenzie, 1977).…”

Section: Response To 5-ht In Cerebral Arteriolesmentioning

confidence: 99%

Regional differences in 5-HT receptors in cerebral and testicular arterioles of the rat as revealed by Ca2+ imaging of real-time confocal microscopy: variances by artery size and organ specificity

Masu

Saino

Kuroda

et al. 2008

Archives of Histology and Cytology

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were caused by both Ca 2+ influx and mobilization. E x p e r i m e n t s u s i n g a g o n i s t s a n d a n t a g o n i s t s a l s o revealed that cerebral arteriole smooth muscles possess 5-HT1a, 1b, 2 (G-protein-coupled type), and 3 (ion channel type) receptors; specifically, 5-HT2 plays a major role in these responses. On the other hand, in testicular vessels, there were few regional differences among responses to 5-HT, and both large-and small-sized arterioles responded to 5-HT. The responses were caused by only Ca 2+ mobilization mediated 5-HT1a and 2. These results indicate that arterioles in different tissues may respond to 5-HT in different manners. Regional differences and the size-dependent manner of responses to 5-HT in cerebral blood vessels also indicate that the regulatory mechanism of blood circulation is highly differentiated in each region of the central nervous system.

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Section: Response To 5-ht In Cerebral Arteriolesmentioning

confidence: 99%

Regional differences in 5-HT receptors in cerebral and testicular arterioles of the rat as revealed by Ca2+ imaging of real-time confocal microscopy: variances by artery size and organ specificity

Masu

Saino

Kuroda

et al. 2008

Archives of Histology and Cytology

View full text Add to dashboard Cite

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“…5-hydroxytriptamine (5-HT: serotonin) is a neurotransmitter that is involved in a wide variety of physiological functions via its interaction with multiple receptor subtypes, mainly in the central and peripheral nervous systems and in the gastrointestinal tract (2, 8,12,55). In addition, 5-HT is a wellknown potent vasoconstrictor agent in several arteries (77,78,80). A role for 5-HT in the control of brain perfusion has been widely considered (41,85,86).…”

Section: Preparation Of the Ciliary Arteries And Vorticose Veinsmentioning

confidence: 99%

“…Previous pharmaco-physiological studies reported that the 5-HT 1 and 5-HT 2 receptor families most commonly mediated the contractile responses to 5-HT in certain vascular smooth muscles (27,34,35,45,73,76), but the 5-HT-induced [Ca 2+ ] i dynam- logical studies have reported that 5-HT constricted large arteries and reduced the vascular resistance of small vessels (11,15,57,64,77,78). In vivo observation confirmed that 5-HT induced the contraction of the pial vessel (> 200 μm in resting diameter), whereas small vessels (< 70 μm in diameter) were dilated (28).…”

Section: Response To 5-ht In the Posterior Ciliary Arteriesmentioning

confidence: 99%

<b>Different effect of serotonin on intracellular calcium ion dynamics in the smooth muscle cells between rat posterior ciliary artery and vorticose </b><b>vein </b>

et al. 2016

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5-hydroxytriptamine (5-HT: serotonin) is an important transmitter that causes vessel constriction, although few studies have examined the effect of 5-HT on venous smooth muscles. The intracellular Ca 2+ concentration ([Ca 2+ ] i ) plays an essential role in stimulus-response coupling in numerous tissue/cells including vascular smooth muscle cells. The present study was performed to examine whether differences between arteries and veins in the response to 5-HT can be detected under confocal microscope with respect to [Ca 2+ ] i dynamics. In posterior ciliary arteries of rats, 5-HT induced a [Ca 2+ ] i increase. The 5-HT-induced responses were caused by both Ca 2+ influx and mobilization. Agonist and antagonist experiments revealed that arterial smooth muscles possess 5-HT 1a, 1b, 2 (Gprotein-coupled type) and 5-HT 3 (ion channel type) receptors, and that 5-HT 2 in particular plays a major role in these responses. For vorticose veins, the 5-HT-induced responses were also caused by both Ca 2+ influx and mobilization. However, the cAMP dependent pathway (5-HT 4-7 ) was found to be significant in vasocontraction with respect to 5-HT in these vessels. Thus, Ca 2+ mobilization was induced by 5-HT 2 and 5-HT 4-7 in a vessel-dependent manner, whereas Ca 2+ influx universally was induced by 5-HT 3 . These results indicate that the posterior ciliary arteries and vorticose veins in the same tissue might differ greatly in their responses to stimulus.Retinal vein occlusion is the second most common retinal vascular disorder after diabetic retinopathy and is considered to be an important cause of visual impairment (9, 54). Ischemic disorders of the optic nerve constitute an important cause of visual loss (7, 30). For example, ischemic optic neuropathy, an acute disorder of the optic nerve, is now known to be a common yet serious vision-threatening disease in middle-aged and elderly populations (13,72). Similarly, evidence is mounting that vascular insufficiency in the intraorbital portion of the optic nerve might play an important role in amorose glaucomatous optic neuropathy and papilloedema (65, 83). The main vascular sources of the intraorbital portion of the optic nerve consist of the branches of the posterior ciliary artery and the central retinal artery (29,36,50,79). The choroid blood vessels of the eye provide 80-95% of the blood to the ocular structures including the outer retina and ciliary processes (6). The central retinal artery supplies the optic nerve and the inner retina, while the posterior ciliary artery pierces the sclera to enter the choroidal coat of the eye. The central retinal artery ends without significant anastomoses (32). The choroidal vessels are innervated by sympathetic and parasympathetic nerves; the parasympathetic innervation of the choroid derives from the ipsilateral pterygopalatine ganglion (59). Parasympathetic nerve stimulation produces nitric oxide-mediated vasodilation, which

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“…According to the myogenic theory, the smooth muscles respond directly to variations in blood pressure. These may be of importance, because local accumulation of various substances with vasoconstrictor effects, such as bradykinin, histamine and serotonin [57,84], and substances with vasodilatator capacity, such as serotonin [72], affect vascular tone [75]. A third possibility is that autonomic neurons control vascular tone [38,59].…”

Section: Factors Regulating Cerebral Blood Jtowmentioning

confidence: 99%

Pathogenetic mechanisms in vascular dementia

et al. 1994

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Summary. Vascular dementia accounts for approximately20% of all cases of dementia and for about 50% in subjects over 80 years. Thromboembolism with multiple cerebral infarcts was considered to be almost the only pathogenetic pathway of vascular dementia, with multiinfarct dementia as its clinical manifestation. However, there is a great heterogeneity of vascular dementia syndromes and pathological subtypes, as documented by the number of pathogenetic mechanisms now known to underlie the clinical picture. They include thromboembolism and extracerebral and cerebral factors. Among the extracerebral factors are ischemic hypoxic dementia (i.e., dementia due to hypoperfusion), vasculitis, hyperviscosity and abnormalities of hemostasis. Among the cerebral factors are lipohyalinosis, cerebral amyloid angiopathy, disruption of the blood-brain barrier and altered regulation of cerebral blood flow. Therefore, the approach to vascular dementia should take the heterogeneity into account. In this context, the importance of non-infarct type should be considered; subcortical white matter disorder seems to be a noteworthy common pathway of vascular dementia produced by various vascular mechanisms. Finally, the heterogeneity of the vascular mechanisms involved in vascular d~mentia -namely hypoperfusion -might be a factor that can be positively influenced by targeted therapeutic intervention.

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Serotonin and vascular reactivity

Cited by 97 publications

References 37 publications

Regional differences in 5-HT receptors in cerebral and testicular arterioles of the rat as revealed by Ca2+ imaging of real-time confocal microscopy: variances by artery size and organ specificity

Regional differences in 5-HT receptors in cerebral and testicular arterioles of the rat as revealed by Ca2+ imaging of real-time confocal microscopy: variances by artery size and organ specificity

<b>Different effect of serotonin on intracellular calcium ion dynamics in the smooth muscle cells between rat posterior ciliary artery and vorticose </b><b>vein </b>

Pathogenetic mechanisms in vascular dementia

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