Serotonin as an integrator of leech behavior and muscle mechanical performance

Gerry, Shannon P.; Daigle, Amanda J.; Feilich, Kara; Liao, Jessica C.; Oston, Azzara L.; Ellerby, David J.

doi:10.1016/j.zool.2012.02.001

Cited by 8 publications

(3 citation statements)

References 44 publications

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“…The FMRFamide peptides have an important role in heart regulation and body wall muscle modulation in leeches [23]. Serotonin, found in the mid body of the ganglion, is a known modulator of tension in leech muscles, affecting the passive forces operating in all physiological muscles [13]. Thus, the results found here indicated that the feeding-mediated distension of the leech body wall was involving heart regulation.…”

Section: Deg Analysis Between Hunger and Blood-fed Leechessupporting

confidence: 49%

“…indicating that the body wall has an autonomic regulation system, when removing central nervous system (CNS), residual amount of muscle activation [7]. In fact, serotonin, a known modulator of tension in leech muscles, affected the passive forces in all physiological muscles [13]. Overall, feeding-mediated body distension and contraction in hungry leeches, the positive autonomic musculature, and the function for pachyemia, contribute for the resemblance between the tubular body of the leech and the heart of mammals.…”

Section: Introductionmentioning

confidence: 99%

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Heart Failure-Like Reaction Is Likely Involved in the Feeding Behaviour of Blood-Sucking Leeches

Yang,

Shu,

Wang

et al. 2024

ABB

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Medicinal leeches have been utilized in therapy for thousands of years. However, the adaptation physiology between leeches and hosts is not fully understand. To disclose the molecular mechanisms of adaptation between leech and host, the body transcriptomes of hunger and fed blood-sucking Poecilobdella javanica, Haemadipsa cavatuses, and Hirudo nipponia leeches were obtained by RNA sequencing, after comparison, a stratified unigenes group was obtained, which closely correlated to body distension. In the group, Rfamide receptor decreased significantly (P < 0.05) while serotonin receptor increased significantly (P < 0.05). Moreover, four KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways, including cardiac muscle contraction, complement and coagulation cascades, renin-angiotensin system, and hypertrophic cardiomyopathy were significantly enriched. The unigenes annotation, neuroregulators correlation analysis and induced function of the KEGG pathways, were consistently supported the same result as: vasoconstriction and systole reaction enhance in hunger leeches and vice versa vasodilation and diastole increase in fed leeches, meanwhile, Interspecific comparison and correlative analyses of physiological function showed that the strongest reaction of induced heart failure from four KEGG occur in strongest reaction of systole in hungry P. javanica and in strongest reaction of diastole in fed H. nipponia.Overall, heart failure is likely a physiological function involved in feeding behaviour.

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Section: Deg Analysis Between Hunger and Blood-fed Leechessupporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Heart Failure-Like Reaction Is Likely Involved in the Feeding Behaviour of Blood-Sucking Leeches

Yang,

Shu,

Wang

et al. 2024

ABB

View full text Add to dashboard Cite

show abstract

“…However, at least some of the increase seen in the stimulated heart with SGRN is likely a direct effect of the neuropeptide on the muscle because there is some increase in pre-stretch transverse passive force even in the absence of the CG. To our knowledge, this is the first report of a significant effect of neuroactive compounds on passive muscle properties in crustaceans; however, serotonin has been shown to decrease passive muscle tension in leeches (Gerry and Ellerby, 2011;Gerry et al, 2012). Because passive forces at low extensions are dominated by titin, perhaps neuropeptides affect titin function in lobster cardiomyocytes.…”

Section: Neuromodulators Exert Direct Effects On the Heartmentioning

confidence: 79%

Forces generated during stretch in the heart of the lobsterHomarus americanusare anisotropic and are altered by neuromodulators

Dickinson

Johnson

Ellers

2016

Journal of Experimental Biology

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Mechanical and neurophysiological anisotropies mediate threedimensional responses of the heart of Homarus americanus. Although hearts in vivo are loaded multi-axially by pressure, studies of invertebrate cardiac function typically use uniaxial tests. To generate whole-heart length-tension curves, stretch pyramids at constant lengthening and shortening rates were imposed uniaxially and biaxially along longitudinal and transverse axes of the beating whole heart. To determine whether neuropeptides that are known to modulate cardiac activity in H. americanus affect the active or passive components of these length-tension curves, we also performed these tests in the presence of SGRNFLRFamide (SGRN) and GYSNRNYLRFamide (GYS). In uniaxial and biaxial tests, both passive and active forces increased with stretch along both measurement axes. The increase in passive forces was anisotropic, with greater increases along the longitudinal axis. Passive forces showed hysteresis and active forces were higher during lengthening than shortening phases of the stretch pyramid. Active forces at a given length were increased by both neuropeptides. To exert these effects, neuropeptides might have acted indirectly on the muscle via their effects on the cardiac ganglion, directly on the neuromuscular junction, or directly on the muscles. Because increases in response to stretch were also seen in stimulated motor nerve-muscle preparations, at least some of the effects of the peptides are likely peripheral. Taken together, these findings suggest that flexibility in rhythmic cardiac contractions results from the amplified effects of neuropeptides interacting with the length-tension characteristics of the heart.

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Serotonin-immunoreactive neural system and contractile system in the hydroid Cladonema (Cnidaria, Hydrozoa)

Mayorova

Kosevich

2013

Invert Neurosci

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Serotonin is a widespread neurotransmitter which is present in almost all animal phyla including lower metazoans such as Cnidaria. Serotonin detected in the polyps of several cnidarian species participates in the functioning of a neural system. It was suggested that serotonin coordinates polyp behavior. For example, serotonin may be involved in muscle contraction and/or cnidocyte discharge. However, the role of serotonin in cnidarians is not revealed completely yet. The aim of this study was to investigate the neural system of Cladonema radiatum polyps. We detected the net of serotonin-positive processes within the whole hydranth body using anti-serotonin antibodies. The hypostome and tentacles had denser neural net in comparison with the gastric region. Electron microscopy revealed muscle processes throughout the hydranth body. Neural processes with specific vesicles and neurotubules in their cytoplasm were also shown at an ultrastructural level. This work demonstrates the structure of serotonin-positive neural system and smooth muscle layer in C. radiatum hydranths.

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Serotonin as an integrator of leech behavior and muscle mechanical performance

Cited by 8 publications

References 44 publications

Heart Failure-Like Reaction Is Likely Involved in the Feeding Behaviour of Blood-Sucking Leeches

Heart Failure-Like Reaction Is Likely Involved in the Feeding Behaviour of Blood-Sucking Leeches

Forces generated during stretch in the heart of the lobsterHomarus americanusare anisotropic and are altered by neuromodulators

Serotonin-immunoreactive neural system and contractile system in the hydroid Cladonema (Cnidaria, Hydrozoa)

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