Serotonin suppresses food anticipatory activity and synchronizes the food-entrainable oscillator during time-restricted feeding

Rozenblit-Susan, Sigal; Chapnik, Nava; Genzer, Yoni; Froy, Oren

doi:10.1016/j.bbr.2015.10.019

Cited by 11 publications

(10 citation statements)

References 23 publications

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“…In mammals, often studied effects of SSRI on individuals exposed as adults, are reduced levels of anxiety (Mombereau et al 2010 ; Sanchez et al 2003 ), altered feeding behaviour (Rozenblit-Susan et al 2016 ) and reduced levels of aggression (Caldwell and Miczek 2007 ). A wide range of literature on SSRI effects in fish paints a similar picture, with exposed animals exhibiting a behavioural phenotype characterised by reduced anxiety and stress response.…”

Section: Introductionmentioning

confidence: 99%

Developmental exposure to the SSRI citalopram causes long-lasting behavioural effects in the three-spined stickleback (Gasterosteus aculeatus)

et al. 2017

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Selective Serotonin re-uptake inhibitors (SSRIs) are a class of psychotropic drugs used to treat depression in both adolescents and pregnant or breast-feeding mothers as well as in the general population. Recent research on rodents points to long-lasting behavioural effects of pre- and perinatal exposure to SSRIs which last into adulthood. In fish however, studies on effects of developmental exposure to SSRIs appears to be non-existent. In order to study effects of developmental SSRI exposure in fish, three-spine sticklebacks were exposed to 1.5 µg/l of the SSRI citalopram in the ambient water for 30 days, starting two days post-fertilisation. After approximately 100 days of remediation in clean water the fish were put through an extensive battery of behavioural tests. Feeding behaviour was tested as the number of bites against a piece of food and found to be increased in the exposed fish. Aggression levels were measured as the number of bites against a mirror image during 10 min and was also found to be significantly increased in the exposed fish. Novel tank behaviour and locomotor activity was tested in an aquarium that had a horizontal line drawn half-way between the bottom and the surface. Neither the latency to the first transition to the upper half, nor the number of transitions or the total time spent in the upper half was affected by treatment. Locomotor activity was significantly reduced in the exposed fish. The light/dark preference was tested in an aquarium where the bottom and walls were black on one side and white on the other. The number of transitions to the white side was significantly reduced in the exposed fish but there was no effect on the latency to the first transition or the total time spent in the white half. The results in the current study indicate that developmental SSRI exposure causes long-lasting behavioural effects in fish and contribute to the existing knowledge about SSRIs as environmental pollutants.

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Section: Introductionmentioning

confidence: 99%

Developmental exposure to the SSRI citalopram causes long-lasting behavioural effects in the three-spined stickleback (Gasterosteus aculeatus)

et al. 2017

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“…There are several methodological differences between our study and the previous studies investigating the role of 5-HT in circadian entrainment to scheduled feeding. Firstly, all the prior studies of 5-HT and FAA (Shibata et al, 1995;Hsu et al, 2010;Rozenblit-Susan et al, 2016) measured activity using running wheels, which are known to enhance FAA (Flôres et al, 2016), whereas we measured high intensity activity behaviors occurring in the normal home cage. Possibly most importantly, the studies by Shibata et al (1995) and Rozenblit-Susan et al (2016) study used pharmacology, and SSRI medications have been noted to have pleiotropic effects (Isaac et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…This notion was supported by an earlier study of 5-HT by Shibata and colleagues, who used 5-HT receptor antagonists (5-HT2 receptor antagonists, mianserin and ritanserin, and a 5-HT3 receptor antagonist, Y25130) to rescue FAA in aged rats in a short-term time restricted feeding study ( Shibata et al, 1995 ). More recently, another pharmacological study described 5-HT as a negative regulator of FAA and a possible “resetting” function of 5-HT of food entrained activity rhythms ( Rozenblit-Susan et al, 2016 ). Using an inhibitor for the rate limiting enzyme for 5-HT production, tryptophan hydroxylase (Tph), Rozenblit-Susan et al (2016) observed a free running component of FAA (in constant darkness) and that treatment with a selective serotonin reuptake inhibitor (SSRI) decreased the amplitude of FAA.…”

Section: Introductionmentioning

confidence: 99%

“…More recently, another pharmacological study described 5-HT as a negative regulator of FAA and a possible “resetting” function of 5-HT of food entrained activity rhythms ( Rozenblit-Susan et al, 2016 ). Using an inhibitor for the rate limiting enzyme for 5-HT production, tryptophan hydroxylase (Tph), Rozenblit-Susan et al (2016) observed a free running component of FAA (in constant darkness) and that treatment with a selective serotonin reuptake inhibitor (SSRI) decreased the amplitude of FAA.…”

Section: Introductionmentioning

confidence: 99%

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Food Anticipatory Activity on Circadian Time Scales Is Not Dependent on Central Serotonin: Evidence From Tryptophan Hydroxylase-2 and Serotonin Transporter Knockout Mice

Gallardo

Martin

Steele

2020

Front. Mol. Neurosci.

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A number of studies implicate biogenic amines in regulating circadian rhythms. In particular, dopamine and serotonin influence the entrainment of circadian rhythms to daily food availability. To study circadian entrainment to feeding, food availability is typically restricted to a short period within the light cycle daily. This results in a notable increase in pre-meal activity, termed "food anticipatory activity" (FAA), which typically develops within about 1 week of scheduled feeding. Several studies have implicated serotonin as a negative regulator of FAA: (1) aged rats treated with serotonin 5-HT2 and 3 receptor antagonists showed enhanced FAA, (2) mice lacking for the 2C serotonin receptor demonstrate enhanced FAA, and (3) pharmacologically increased serotonin levels suppressed FAA while decreased serotonin levels enhanced FAA in mice. We sought to confirm and extend these findings using genetic models with impairments in central serotonin production or re-uptake, but were surprised to find that both serotonin transporter (Slc6a4) and tryptophan hydroxylase-2 knockout mice demonstrated a normal behavioral response to timed, calorie restricted feeding. Our data suggest that FAA is largely independent of central serotonin and/or serotonin reuptake and that serotonin may not be a robust negative regulator of FAA.

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“…Feeding, aggression, and boldness are behavioural traits that are all to some degree influenced by the serotonergic system. Administration of serotonin has a suppressing effect on feeding in organisms as diverse as goldfish (Carassius auratus) (De Pedro et al 1998), rainbow trout (Oncorhynchus mykiss) (Ortega et al 2013), rodents (Voigt and Fink 2015;Rozenblit-Susan et al 2016), and ants (Falibene et al 2012). Acute serotonin administration suppresses aggression in the fighting fish (Betta splendens) (Clotfelter et al 2007).…”

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confidence: 99%

Divergent Response to the SSRI Citalopram in Male and Female Three-Spine Sticklebacks (Gasterosteus aculeatus)

Kellner

Olsén

2020

Arch Environ Contam Toxicol

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Selective serotonin reuptake inhibitors (SSRIs) are psychotropic pharmaceuticals used as antidepressants. SSRIs are commonly found in surface waters in populated areas across the globe. They exert their effect by blocking the serotonin re-uptake transporter in the presynaptic nerve ending. The present study examined whether behavioural effects to exposure to SSRI citalopram depend on personality and sex in the stickleback (Gasterosteus aculeatus). Three aspects of stickleback behaviour are examined: feeding behaviour, aggression, and boldness. We exposed sticklebacks to 350–380 ng/l citalopram for 3 weeks. Feeding and aggressive behaviour were recorded before and after exposure, whereas scototaxis behaviour was tested after exposure. The results show treatment effects in feeding and aggressive behaviour. Feeding is suppressed only in the male group (χ2 = 20.4, P < 0.001) but not in the females (χ2 = 0.91, P = 0.339). Aggressive behaviour was significantly affected by treatment (χ2 = 161.9, P < 0.001), sex (χ2 = 86.3, P < 0.001), and baseline value (χ2 = 58.8, P < 0.001). Aggressiveness was suppressed by citalopram treatment. In addition, the fish showed no change in aggression and feeding behaviour over time regardless of sex and treatment, which indicate personality traits. Only females are affected by treatment in the scototaxis test. The exposed females spent significantly (χ2 = 5.02, P = 0.050) less time in the white zone than the female controls.

show abstract

Serotonin suppresses food anticipatory activity and synchronizes the food-entrainable oscillator during time-restricted feeding

Cited by 11 publications

References 23 publications

Developmental exposure to the SSRI citalopram causes long-lasting behavioural effects in the three-spined stickleback (Gasterosteus aculeatus)

Developmental exposure to the SSRI citalopram causes long-lasting behavioural effects in the three-spined stickleback (Gasterosteus aculeatus)

Food Anticipatory Activity on Circadian Time Scales Is Not Dependent on Central Serotonin: Evidence From Tryptophan Hydroxylase-2 and Serotonin Transporter Knockout Mice

Divergent Response to the SSRI Citalopram in Male and Female Three-Spine Sticklebacks (Gasterosteus aculeatus)

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