Serotonin Syndrome Induced by Administration of Venlafaxine and Phenelzine

Heisler, Mark A; Guidry, James R.; Arnecke, Bernadette

doi:10.1177/106002809603000115

Cited by 14 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many treatments for SS have been described including the 5-HT 2 blockers, methysergide (Sandyk, 1986) and cyproheptadine (see Table 2) (Goldberg and Huk, 1992;Beasley et al, 1993;Muly et al, 1993;Lappin and Auchincloss, 1994;Klysner et al, 1995;George and Godleski, 1996), and the 5-HT 1A blocker propranolol (Rivers and Horner, 1970;Guze and Baxter, 1986;Klee and Kronig, 1993;Lappin and Auchincloss, 1994;Ruiz, 1994;Heisler et al, 1996;Gillman, 1997b). Various benzodiazepines have been used (Halman and Goldblum, 1990;Ooi, 1991;Lejoyeux et al, 1992;Nierenberg and Semprebon, 1993;Brannan et al, 1994;Graber et al, 1994;Ruiz, 1994;Skop et al, 1994;Baetz and Malcolm, 1995;Reeves and Bullen, 1995;Hodgman et al, 1997) as well as nitroglycerine , and chlormethiazole (Bedford-Russel et al, 1992).…”

Section: Treatmentmentioning

confidence: 99%

The serotonin syndrome and its treatment

Gillman¹

1999

J Psychopharmacol

276

186

View full text Add to dashboard Cite

Serotonin syndrome is caused by drug induced excess of intrasynaptic 5-hydroxytryptamine. The clinical manifestations are mediated by the action of 5-hydroxytryptamine on various subtypes of serotonin receptors. There is no effective drug treatment established. The history of the treatment of serotonin syndrome with 5-hydroxytryptamine blocking drugs is reviewed. A literature search was undertaken using both Medline and a manual search of the older literature. Reports of cases treated with the 5-HT2 blockers cyproheptadine and chlorpromazine were identified and analysed. There is some evidence suggesting the efficacy of chlorpromazine and cyproheptadine in the treatment of serotonin syndrome. The evidence for cyproheptadine is less substantial, perhaps because the dose of cyproheptadine necessary to ensure blockade of brain 5-HT2 receptors is 20-30 mg, which is higher than that used in the cases reported to date (4-16 mg).

show abstract

Section: Treatmentmentioning

confidence: 99%

The serotonin syndrome and its treatment

Gillman¹

1999

J Psychopharmacol

276

186

View full text Add to dashboard Cite

show abstract

“…18(p581) In adults, these hallucinations are most often associated with withdrawal of serotonin reuptake inhibitors or with serotonin syndrome. [19][20][21][22][23][24] However, there are descriptions in adults of drug-induced complex visual hallucinations as a result of serotonin reuptake inhibitors. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] To date, only 1 case report exists of a patient with venlafaxine-induced visual hallucinations not due to a serotonin syndrome or a withdrawal reaction; the patient in that report had a posterior cerebral artery infarction.…”

Section: Venlafaxine-induced Complex Visual Hallucinations In a 17-yementioning

confidence: 99%

Venlafaxine-Induced Complex Visual Hallucinations in a 17-Year-Old Boy

Jacob¹,

Ash²

2009

J. Clin. Psychiatry

View full text Add to dashboard Cite

“…Many recent case reports involve the use of antidepressant drug combinations, including venlafaxine and tranylcypromine (Brubacher et al, 1996;Hodgman et al, 1997), venlafaxine and phenelzine (Heisler et al, 1996) and trazodone with¯uoxetine (George and Godleski, 1996). Fluvoxamine therapy resulted in a serotonergic reaction in a patient previously treated with paroxetine (Bastani et al, 1996).…”

mentioning

confidence: 99%