Serotonin transporter and memory

Meneses, Alfredo; Pérez-García, Georgina; Ponce-López, Teresa; Tellez, Ruth; Castillo, Carlos

doi:10.1016/j.neuropharm.2011.01.018

Cited by 50 publications

(26 citation statements)

References 134 publications

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“…Serotonin transporter (SERT) expression has been found to be vital for memory development. Decreased expression of this transporter was found in Alzheimer's disease and other memory impairments and dementia [27]. Benmansour et al showed a decrease in SERT expression within 21 days (3 weeks) following SSRI use [28].…”

Section: Discussionmentioning

confidence: 99%

Cognitive Function before and during Treatment with Selective Serotonin Reuptake Inhibitors in Patients with Depression or Obsessive-Compulsive Disorder

et al. 2016

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Objectives. Identification of adverse effects of selective serotonin reuptake inhibitors (SSRIs) is of great importance due to their extensive use in medicine. Some studies have reported the effects of SSRIs on cognitive functions, but the results are conflicting. This study was designed to assess the effect of these drugs on cognition of patients with depression or obsessive-compulsive disorder (OCD). Methods. Patients with depression or OCD, naïve to therapy, and candidates of receiving one drug from SSRI class, voluntarily, entered this study. Mini-Mental State Examination (MMSE) test was the tool to assess their cognitive functions. MMSE scores of each patient were recorded prior to taking SSRIs and at weeks 3, 5, and 8 of drug therapy. Results. 50 patients met our inclusion criteria, with a baseline mean MMSE score of 23.94. At 3, 5, and 8 weeks of treatment, the mean scores were 22.1, 21.4, and 20.66, respectively. With a p value of <0.0001, the gradual decline was statistically significant. Conclusion. The MMSE scores of our patients showed a gradual decline over the consecutive weeks after taking SSRI drugs. It seems that the use of SSRIs in patients with depression or OCD, can cause cognitive dysfunction in the acute phase of treatment.

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Section: Discussionmentioning

confidence: 99%

Cognitive Function before and during Treatment with Selective Serotonin Reuptake Inhibitors in Patients with Depression or Obsessive-Compulsive Disorder

et al. 2016

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“…A wealth of experimental animal studies demonstrate the role of the serotonin systems in memory and its dysfunctions, even if their role is still poorly understood (Meneses et al, 2011; Meneses, 2013; Gasbarri and Pompili, 2014; Gasbarri et al, 2016; Meneses and Gasbarri, 2016). It is beyond the scope of this paper to describe the results of all these studies (for an in-depth analysis please refer to Meneses et al, 2011; Roberts and Hedlund, 2012; Meneses, 2013; Glikmann-Johnston et al, 2015; Meneses and Gasbarri, 2016).…”

Section: The Role Of 5-ht In Working Spatial and Episodic Memorymentioning

confidence: 99%

“…It is beyond the scope of this paper to describe the results of all these studies (for an in-depth analysis please refer to Meneses et al, 2011; Roberts and Hedlund, 2012; Meneses, 2013; Glikmann-Johnston et al, 2015; Meneses and Gasbarri, 2016). In this context, we will focus only on the studies more relevant to our discussion.…”

Section: The Role Of 5-ht In Working Spatial and Episodic Memorymentioning

confidence: 99%

“…The serotonin transporter (SERT) is an integral membrane protein with the role of taking up serotonin released during serotonergic neurotransmission by transporting it from synaptic spaces into presynaptic neurons (Meneses et al, 2011; Coleman et al, 2016). Numerous gene variants have been identified, which have a significant impact on its functioning.…”

Section: The Role Of 5-ht In Working Spatial and Episodic Memorymentioning

confidence: 99%

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Neurobiology of Anorexia Nervosa: Serotonin Dysfunctions Link Self-Starvation with Body Image Disturbances through an Impaired Body Memory

Riva

2016

Front. Hum. Neurosci.

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The etiology of anorexia nervosa (AN) is still unclear, despite that it is a critical and potentially mortal illness. A recent neurobiological model considers AN as the outcome of dysfunctions in the neuronal processes related to appetite and emotionality (Kaye et al., 2009, 2013). However, this model still is not able to answer a critical question: What is behind body image disturbances (BIDs) in AN? The article starts its analysis from reviewing some of the studies exploring the effects of the serotonin systems in memory (episodic, working, and spatial) and its dysfunctions. The review suggests that serotonin disturbances may: (a) facilitate the encoding of third person (allocentric) episodic memories; (b) facilitate the consolidation of emotional episodic memories (e.g., teasing), if preceded by repeated stress; (c) reduce voluntary inhibition of mnestic contents; (d) impair allocentric spatial memory. If we discuss these results within the interpretative frame suggested by the “Allocentric Lock Hypothesis” (Riva, 2012, 2014), we can hypothesize that altered serotoninergic activity in AN patients: (i) improves their ability to store and consolidate negative autobiographical memories, including those of their body, in allocentric perspective; (ii) impairs their ability to trigger voluntary inhibition of the previously stored negative memory of the body; (iii) impairs their capacity to retrieve/update allocentric information. Taken together, these points suggest a possible link between serotonin dysfunctions, memory impairments and BIDs: the impossibility of updating a disturbed body memory using real time experiential data—I'm locked to a wrong body stored in long term memory—pushes AN patients to control body weight and shape even when underweight.

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“…Certainly, it is a complex and multifocal issue; hence, herein we are addressing a few aspects using some examples, which should provide an analytic framework offering some clues. For instance, when comparing 5-HT 6 receptor drugs, memory tasks, and protocols of training, similar and some differential outcomes are observed between, for example, appetitive associative Pavlovian/instrumental autoshaping versus aversively motivated water Maze (spatial memory) and inhibitory avoidance (Meneses et al, 2011b). For instance, the development of potent and selective 5-HT 6 receptor antagonists has been crucial in the clarification of the role of this receptor on memory.…”

Section: -Ht Pathways Receptors and Transporter: Memory Functions mentioning

confidence: 99%

Neurotransmitters and Memory

Meneses

2014

Identification of Neural Markers Accompanying Memory

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Serotonin transporter and memory

Cited by 50 publications

References 134 publications

Cognitive Function before and during Treatment with Selective Serotonin Reuptake Inhibitors in Patients with Depression or Obsessive-Compulsive Disorder

Cognitive Function before and during Treatment with Selective Serotonin Reuptake Inhibitors in Patients with Depression or Obsessive-Compulsive Disorder

Neurobiology of Anorexia Nervosa: Serotonin Dysfunctions Link Self-Starvation with Body Image Disturbances through an Impaired Body Memory

Neurotransmitters and Memory

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