Serotonin transporter gene polymorphisms in patients with chronic tension-type headache: A preliminary study

Akcali, Aylin; Tataroglu, Cengiz; Erdal, Emin; Aydın, Neriman; Pehlıvan, Sacide

doi:10.4103/0028-3886.41993

Cited by 3 publications

(1 citation statement)

References 29 publications

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“… 31 Serum serotonin levels were associated with pain thresholds in patients with chronic pain 32 and were altered in TTH patients. 33 , 34 However, RLS has previously been linked to disturbances of the A11 (dorsal-posterior hypothalamic) dopaminergic system. 35 However, using SPECT imaging, Jhoo et al found that decreased pontine and medullary serotonin transporter availability correlated with the increased severity of RLS, suggesting that RLS may entail brainstem serotonergic tone.…”

Section: Discussionmentioning

confidence: 99%

Risk of Restless Legs Syndrome Following Tension-Type Headache

et al. 2015

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Migraine and restless legs syndrome (RLS) appear to be associated, but the relationship between tension-type headache (TTH) and RLS is unknown. This nationwide, population-based, retrospective cohort study explored the potential association between TTH and RLS.We identified 15,504 patients with newly diagnosed TTH from 2000 to 2007 and 62,016 individuals without TTH who were selected by frequency matched based on sex, age, and the index year. The study participants were followed until diagnosed with RLS, withdrawal from the NHI program, or the end of 2011. Cox proportional hazard models were used to identify risk factors for RLS in TTH patients.After adjusting for sex, age, comorbidity, and medications, TTH was significantly associated with an increased risk of RLS (hazard ratio [HR] = 1.57, 95% confidence interval [CI] = 1.22–2.02). The risk was most prominent in patients aged 20 to 39 years in the TTH group, which exhibited a 2.60-fold higher risk (95% confidence interval = 1.53–4.42) of RLS compared with the non-TTH group. The TTH group had a higher risk of RLS than that of the non-TTH group regardless of sex.Tension-type headache appears to be associated with an increased risk of developing RLS. This similarity to migraines may indicate that headache and RLS have a coincident pathophysiological mechanism, a possibility requiring further study. Clinicians should be more attentive to RLS as a possible comorbidity in patients with TTH.

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Section: Discussionmentioning

confidence: 99%

Risk of Restless Legs Syndrome Following Tension-Type Headache

et al. 2015

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Tension-type headache associated with obstructive sleep apnea: a nationwide population-based study

Chiu

Lee

et al. 2015

J Headache Pain

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BackgroundThere is still controversy regarding the association between primary headaches and obstructive sleep apnea. We explored the relationship between tension-type headache (TTH) and obstructive sleep apnea (OSA) using a large nationwide population-based data set in Taiwan.MethodsWe identified 4759 patients diagnosed with OSA from the Taiwan Longitudinal Health Insurance Database, based on polysomnography, as the OSA group. We then randomly selected 19036 subjects without OSA, matched by sex and age, to serve as the non-OSA group. The multivariate Cox proportional hazards model with matching for age and sex was used to assess the possible associations between TTH and OSA among the patients.ResultsThe prevalence of TTH was 10.2% among OSA patients and 7.7% among non-OSA patients (p < 0.001). The multivariate Cox proportional hazards model revealed patients with OSA were more likely to have TTH (hazard ratio, 1.18; 95% CI, 1.06–1.31) (p = 0.003) than patients in the non-OSA group.ConclusionPatients with OSA had a higher likelihood of developing TTH than patients in the non-OSA group. Further studies of physiological patterns between OSA and TTH are needed to confirm the study findings.

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Genetic Aspect of Headache

Edgünlü¹,

Çelik²

2017

Current Perspectives on Less-Known Aspects of Headache

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Headache is a multifactorial disease and the genetic basis is not clear yet. We review recent findings about molecular basis of subtypes of headache. The fundamentals of molecular genetics and the recent advances in this area are important for clinicians to understand the pathogenesis of the disorder. Recent studies provide a foundation for critical appraisal of the literature, unprecedented insights and reveal promising treatment targets for future drug development. This chapter provides an overview of molecular genetics, epigenetic and genome-wide association studies on headache. In summary, we try to explain the state-of-the-art molecular basis of headache and the possible future direction in this field of research studies. According to recent studies the main types of are evaluative, exploratory about molecular basis of headache. In recent years, new studies have been designed to provide an update and understanding of the modern day genetics, the advances in genetic research and methods and a basis for understanding the strategy by which advances in molecular genetics can be applied for understanding complex polygenetic diseases such as migraine.

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Serotonin transporter gene polymorphisms in patients with chronic tension-type headache: A preliminary study

Cited by 3 publications

References 29 publications

Risk of Restless Legs Syndrome Following Tension-Type Headache

Risk of Restless Legs Syndrome Following Tension-Type Headache

Tension-type headache associated with obstructive sleep apnea: a nationwide population-based study

Genetic Aspect of Headache

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