Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in Streptococcus agalactiae isolates in pregnant women and neonates in Catalonia, Spain

López, Yuly; Parra, Elena; Cepas, Virginio; Sanfeliú, Isabel; Juncosa, T; Andreu, Antònia; Xercavins, Mariona; Pérez, J. Enrique; Sanz, Sergi; Vergara, Andrea; Bosch, Jordi; Soto, Sara M.

doi:10.1016/j.eimc.2017.08.006

Cited by 20 publications

(16 citation statements)

References 27 publications

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“…The predominance of this serotype was observed in pregnant women at the Thai-Myanmar border, where 24% of isolates recovered were CPS II, as reported by Turner and others (30). A study in Catalonia, Spain, assessed GBS isolates from pregnant women and pathogenic strains isolated from neonates with sepsis and found that serotypes Ia and II were significantly more frequent than others as colonizing strains (31). Colonization of Nigerian pregnant women also showed a predominance of serotype Ia, while serotype II accounted for 71.4% of the neonatal colonizing isolates (32).…”

Section: Serotypingmentioning

confidence: 55%

Perinatal Streptococcus agalactiae Epidemiology and Surveillance Targets

2018

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SUMMARY, or group B streptococcus (GBS), is a major neonatal pathogen. Recent data have elucidated the global prevalence of maternal and neonatal colonization, but gaps still remain in the epidemiology of this species. A number of phenotypic and genotypic classifications can be used to identify the diversity of GBS strains, and some are more discriminatory than others. This review explores the main schemes used for GBS epidemiology and further details the targets for epidemiological surveillance. Current screening practices across the world provide a unique opportunity to gain detailed information on maternal colonizing strains and neonatal disease-causing strains, which is vital for monitoring and therapeutics, if sufficient detail can be extracted. Deciphering which isolates are circulating within specific populations and recording targets within invasive strains are crucial steps in monitoring the implementation of therapeutics, such as vaccines, as well as developing novel therapies against prevalent GBS strains. Having a detailed understanding of global GBS epidemiology will prove invaluable for understanding the pathogenesis of this organism and equipping future prevention strategies for success.

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Section: Serotypingmentioning

confidence: 55%

Perinatal Streptococcus agalactiae Epidemiology and Surveillance Targets

2018

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“…Penicillin G is the first antibiotic of choice for intrapartum prophylaxis in pregnant women, followed by first-generation ampicillin and cephalosporin. In cases of patients allergic to penicillin G, options include clindamycin, erythromycin, and vancomycin ( 45 ). Velázquez et al ( 46 ) analyzed 96 strains of S. agalactiae , all of which were sensitive to penicillin G at an MIC ranging from 0.012 to 0.094 μg/ml, results corroborated by the current study findings.…”

Section: Discussionmentioning

confidence: 99%

Garlic: An Alternative Treatment for Group B Streptococcus

Torres

Lima

Torres³

et al. 2021

Microbiol Spectr

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“…[ 15 ] Besides, the erythromycin resistance was particularly high in the USA (54%), France (41.7%), and China (74.1%), but in Spain, only 20.7% of GBS strains were resistant. [ 7 16 17 ] Comparison of distribution of resistant isolates in each group showed this rate was higher among asymptomatic GBS (13/16, 81.2%). Borchardt et al .…”

Section: Discussionmentioning

confidence: 99%

Determination of Capsular Serotypes, Antibiotic Susceptibility Pattern, and Molecular Mechanism of Erythromycin Resistance among Clinical Isolates of Group B Streptococcus in Isfahan, Iran

Motallebirad

Fazeli

Azadi

et al. 2021

Advanced Biomedical Research

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Background: Documented streptococcal resistance to erythromycin has recently been raised. The aim of this study is to identify the molecular mechanism of erythromycin resistance among group B Streptococcus (GBS) strains and to correlate with the clinical origin of strains. Materials and Methods: A total number of 134 colonizing ( n = 36), invasive ( n = 36), noninvasive ( n = 46), and asymptomatic ( n = 16) GBS isolates were characterized by the detection of dltS gene, capsular serotyping, antibiotic susceptibility profiles using disc diffusion method, and screening of the ermB , ermTR , and mefA resistance genes. Results: The distribution of capsular serotypes was as follow: serotype III (24.6%), Ia (21.6%), V (17.9%), Ib (14.9%), II (8.9%), IV (8.9%), VI (1.5%), and VII (1.5%). From 134 GBS isolates, 51 (38%) isolates were resistant to erythromycin. The constitutive macrolide lincosamide streptogrmin B (MLSB) was the most common resistance phenotype (62.7%), followed by inducible MLSB (27.4%) and M phenotype (9.8%). Erythromycin resistance rate was higher among asymptomatic GBS strains (13/16, 81.2%). Serotype III was the most prevalent type among resistant isolates (41.1%). The ermB gene highly distributed among resistant strains (64.7%), followed by ermTR (21.5%) and mefA (9.8%). The ermB gene was related to constitutive MLSB phenotype (84.3%, P < 0.05) and serotypes III (61.9%), Ib (87.5%), and V (83.3%). All M phenotype strains harbored mefA gene and were in association with serotype Ia (90%). Conclusion: The current study suggests that ribosomal modification with erm genes is the main mechanism of erythromycin resistance. Because of relatively high prevalence of erythromycin resistance, double disc test highly recommended for GBS disease treatment and intrapartum prophylaxis among penicillin intolerant patients in our region.

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Serotype, virulence profile, antimicrobial resistance and macrolide-resistance determinants in Streptococcus agalactiae isolates in pregnant women and neonates in Catalonia, Spain

Cited by 20 publications

References 27 publications

Perinatal Streptococcus agalactiae Epidemiology and Surveillance Targets

Perinatal Streptococcus agalactiae Epidemiology and Surveillance Targets

Garlic: An Alternative Treatment for Group B Streptococcus

Determination of Capsular Serotypes, Antibiotic Susceptibility Pattern, and Molecular Mechanism of Erythromycin Resistance among Clinical Isolates of Group B Streptococcus in Isfahan, Iran

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