Serotyping of hepatitis C virus in chronic type C hepatitis in Taiwan: Correlation with genotypes

Kao, Jia‐Horng; Lin, Ho‐Hsiung; Chen, Pei‐Jer; Lai, Ming‐Yang; Wang, Teh‐Hong; Mizokami, Masashi; Chen, Ding‐Shinn

doi:10.1007/bf02389521

Cited by 17 publications

(12 citation statements)

References 45 publications

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“…The virological response to therapy was based on serum HCV RNA levels (42)(43)(44). RVR was defined as an undetectable serum HCV RNA level at day 28.…”

Section: Methodsmentioning

confidence: 99%

Association of IL28B gene variations with mathematical modeling of viral kinetics in chronic hepatitis C patients with IFN plus ribavirin therapy

Hsu

Chen

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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Asian patients with chronic hepatitis C (CHC) are known to have better virological responses to pegylated (Peg) IFN-based therapy than Western patients. Although IL28B gene polymorphisms may contribute to this difference, whether favorable hepatitis C virus (HCV) kinetics during treatment plays a role remains unclear. We enrolled 145 consecutive Taiwanese patients with CHC receiving Peg-IFN α-2a plus ribavirin for the study. Blood samples were taken more frequently at defined intervals in the first 3 d. Peg-IFN was administered at week 1. It was then administered weekly in combination with daily ribavirin for 24 or 48 wk. A mathematical model fitted to the observed HCV kinetics was constructed, which could interpret the transient HCV titer elevation after Peg-IFN treatment. The results demonstrated a comparable viral clearance rate (c = 3.45 ± 3.73) (day −1 , mean ± SD) but lower daily viral production rate (P = 10 6 -10 12 ) in our patients than those reported previously in Western patients. Of 110 patients with a sustained virological response (SVR), 47 (43%) had a transient elevation of viral titer within 12 h (proportion of 12 h/3 d: 44% in non-SVR vs. 70% in SVR; P = 0.029). Among 91 patients with available rs8099917 data, patients with the TT genotype had an early surge of viral titer after therapy and a higher SVR and viral clearance rate than those with the GT genotype. In conclusion, Taiwanese patients with CHC receiving Peg-IFN plus ribavirin therapy have a lower daily viral production rate than Western patients, and the rs8099917 TT genotype may contribute to the increased viral clearance rate and better virological responses in these patients. H epatitis C virus (HCV) infection is the major etiology of chronic liver disease, liver cirrhosis, and hepatocellular carcinoma (1, 2). According to the estimate from the World Health Organization, there are more than 180 million chronic HCV-infected persons worldwide (1-3); hence, effective treatment of chronic hepatitis C (CHC) is important. Nevertheless, the current standard of care for CHC using pegylated (Peg) IFN plus ribavirin is expensive, is effective in only a certain proportion of patients who have CHC, and has many unpleasant adverse effects (4, 5). Therefore, identifying predictive factors of therapeutical response in patients with CHC is important.Several factors have been linked to the therapeutical response of patients who have CHC, including viral factors (6-11), host factors (12-15), metabolic factors (16-18), histological factors (19), types of regimen (4), and duration of infection (20). Among these factors, viral kinetics following antiviral therapy has become widely accepted in both clinical trials and daily practice (21) and increasingly recognized as the most outweighing predictor of sustained virological response (SVR) to IFN-based therapy (22). Using mathematical models of hepatitis C viral kinetics may further clarify the mechanisms of antiviral therapy, the evolution of resistant viral strains, and the length of time necessary to er...

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“…The virological response to therapy was based on serum HCV RNA levels (42)(43)(44). RVR was defined as an undetectable serum HCV RNA level at day 28.…”

Section: Methodsmentioning

confidence: 99%

Association of IL28B gene variations with mathematical modeling of viral kinetics in chronic hepatitis C patients with IFN plus ribavirin therapy

Hsu

Chen

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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“…370.37 IU/ml) [26,27]. Genotyping of HCV was performed by reverse transcriptase-PCR with type-specific primers [28,29]. The detection limit of type-specific primers genotyping method is 100 copies/ml (i.e.…”

Section: Laboratory Assaysmentioning

confidence: 99%

Metabolic profiles in patients with chronic hepatitis C: a case–control study

Hsu

Liu

et al. 2008

Hepatol Int

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BackgroundThe clinical implications of metabolic profiles in patients with chronic hepatitis C remain controversial. To study the association of metabolic abnormalities with chronic hepatitis C, we conducted a case-control study with special emphasis on serum lipid pattern, fasting blood glucose, and adiponectin. Methods We enrolled 500 patients with chronic hepatitis C and 536 sex and age-matched controls. Unadjusted and adjusted associations of demographic and metabolic variables were estimated. Results Chronic hepatitis C patients had higher alanine aminotransferase (ALT) and high-density lipoprotein-cholesterol levels, but lower total cholesterol (TC), triglyceride (TG), and low-density lipoprotein-cholesterol levels than controls. Stratifying ALT level according to its upper limit of normal, HCV infection was associated with younger age, female gender, and higher TC levels in chronic hepatitis C patients with normal ALT levels, but with lower TC and lower TG levels in those with abnormal ALT levels. By using multiple linear regression analyses for subjects with available adiponectin data, presence of HCV infection was independently associated with higher serum adiponectin levels. Conclusions Metabolic profiles of chronic hepatitis C patients are affected by age, gender, serum adiponectin, and ALT levels. Further longitudinal studies are needed to clarify the complex interplay between HCV infection and metabolic profiles.

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“…Polymerase chain reaction (PCR) for qualification and genotyping of HCV RNA was performed as previously described [26].…”

Section: Determination Of Insulin Resistancementioning

confidence: 99%

Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C

Liu¹,

Chen²,

Jeng³

et al. 2005

Journal of Hepatology

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Serotyping of hepatitis C virus in chronic type C hepatitis in Taiwan: Correlation with genotypes

Cited by 17 publications

References 45 publications

Association of IL28B gene variations with mathematical modeling of viral kinetics in chronic hepatitis C patients with IFN plus ribavirin therapy

Association of IL28B gene variations with mathematical modeling of viral kinetics in chronic hepatitis C patients with IFN plus ribavirin therapy

Metabolic profiles in patients with chronic hepatitis C: a case–control study

Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C

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