Serotyping of Toxoplasma gondii in chronically infected pregnant women: predominance of type II in Europe and types I and III in Colombia (South America)

Peyron, François; Lobry, Jean R.; Musset, Karine; Ferrandiz, Josette; Gómez-Marín, Jorge Enrique; Petersen, Eskild; Meroni, Valeria; Rausher, Béatrice; Mercier, Corinne; Picot, Stéphane

doi:10.1016/j.micinf.2006.03.023

Cited by 106 publications

(89 citation statements)

References 38 publications

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“…Recently, a disagreement result with a previous study by Kanková et al (2011) whom observed a decreased in testosterone levels (TTH and FTH) in both laboratory female and male mice infected with virulent strain of Toxoplasma at a latent phase in comparison to uninfected controls. This disagreement may result from the type of parasite strain, which differs in virulence and epidemiological pattern of occurrence (Peyron et al 2006). Thus, the parasite genotype appears to be an important factor influencing the outcome of clinical illness in human (Vallochi et al 2005).…”

Section: Discussionmentioning

confidence: 99%

The effect of toxoplasmosis on the level of some sex hormones in males blood donors in Baghdad

2013

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Toxoplasma gondii is a unique intracellular parasite, which infect a large proportion of the world population, but uncommonly causes clinically significant disease. The present study was performed to estimate the prevalence of toxoplasmosis in 400 apparently healthy blood donor males, their ages were between 18 and 57 years using enzyme linked immunosorbent assay, and to examine the effects of infection on total testosterone, free testosterone and follicle stimulating hormone (FSH) levels in their sera. Seroprevalence showed 10 (2.5 %) and 121 (30 %) of them had IgM and IgG antibodies respectively. Both acute and chronic toxoplasmosis in males recorded higher significant (P \ 0.05) mean concentration for total and free testosterone hormone, they were 12.188 ± 0.73, 7.837 ± 0.52 ng/ ml and 44.121 ± 1.76, 27.984 ± 0.94 pg/ml respectively. The mean concentration of FSH revealed non-significant (P \ 0.05) differences in both disease activities, they were 6.41 ± 0.47 and 6.515 ± 0.51 IU/ml respectively.

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Section: Discussionmentioning

confidence: 99%

The effect of toxoplasmosis on the level of some sex hormones in males blood donors in Baghdad

2013

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“…Therefore, a larger sample size should be carried out in human patients to identify specific T. gondii strains using high resolution typing methods such as multiplex nested PCR-RFLP which can genotype some DNA samples extracted directly from infected tissues. Serotyping of T. gondii strains has proved to be a promising tool using serum samples to overcome the diagnostic challenge (Kong et al, 2003;Peyron et al, 2006;Morisset et al, 2008;Sousa et al, 2008;Sousa et al, 2009). However, due to the limitation of serotyping it is not possible to differentiate type II from non-type II strains particularly in South America where there is a high diversity of T. gondii strain types.…”

Section: Other Diagnostic Methodsmentioning

confidence: 99%

Toxoplasmosis in HIV/AIDS Patients - A Living Legacy

Nissapatorn¹

2011

Microbes, Viruses and Parasites in AIDS Process

101

124

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“…The enhanced ability in type I strains to cross biological barriers likely represents an important advantages in the establishment of disseminated infection. However, both pathogenic and apathogenic isolates have been observed in a study in Brazil belonging to genotype I (Peyron et al, 2006).…”

Section: Toxoplasma Gondii Genotypes and Pathologymentioning

confidence: 99%

Congenital Toxoplasmosis: A Review of its Pathology, Immune Response and Current Treatment Options.

Wellington¹,

Oladipo²,

Chimere

et al. 2010

Sierra Leone j. biomed. res.

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Toxoplasmosis, caused by the protozoan parasite Toxoplasma gondii, is one of the most common parasites of man and other warm-blooded animals. Humans are infected through contaminated food, water, and blood transfusion, organ transplantation or from mother to foetus through the placenta. Severe congenital infections occur as a result of primary T. gondii infection in early pregnancy. Transmission of T.gondii to the foetus can result in serious health problems, including mental retardation, seizures, blindness and death. Frequency of foetal infection is higher when maternal infection occurs later in pregnancy and sequelae are more severe when maternal infections occur early in the first trimester of pregnancy. The ability of the parasite to survive intracellularly largely depends on the blocking of different proapoptotic signaling cascades of the host cells. During pregnancy, however, alterations in the incidence of apoptosis are associated with abnormal placental morphology and function. Both cellular and humoral immune responses control T.gondii infection. Toxoplasma is asymptomatic, infected women can only be detected by serological testing. In many instances, congenital toxoplasmosis can be prevented by educating pregnant women and women of childbearing age about the route of transmission. The need for screening suspected cases of T. gondii will help reduce transmission to the foetus.

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Serotyping of Toxoplasma gondii in chronically infected pregnant women: predominance of type II in Europe and types I and III in Colombia (South America)

Cited by 106 publications

References 38 publications

The effect of toxoplasmosis on the level of some sex hormones in males blood donors in Baghdad

The effect of toxoplasmosis on the level of some sex hormones in males blood donors in Baghdad

Toxoplasmosis in HIV/AIDS Patients - A Living Legacy

Congenital Toxoplasmosis: A Review of its Pathology, Immune Response and Current Treatment Options.

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