SerpinE1

Czekay, Ralf -Peter; Simone, Tessa M.; Higgins, Paul J.

doi:10.1007/978-1-4614-6438-9_101828-1

Cited by 1 publication

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 67 , 68 Moreover, IL‐8, one of the key mediators of the inflammatory response, has been reported to have an important role in angiogenesis, 69 , 70 whereas SERPINE1 has been reported to play an important role in suppressing the adhesion, proliferation, and motility of endothelial and vascular smooth muscle cells. 71 , 72 Increased secretion of SERPINE1 has been observed during inflammation, physical injury, and exposure to angiotensin II. Further, SERPINE1 reportedly participates in the tissue injury repair program by inhibiting proliferation while promoting the migration of cells.…”

Section: Resultsmentioning

confidence: 99%

Assessment of human adipose‐derived stem cell on surface‐modified silicone implant to reduce capsular contracture formation

Sutthiwanjampa

Shin

Ryu

et al. 2021

Bioengineering & Transla Med

View full text Add to dashboard Cite

Medical devices made from poly(dimethylsiloxane) (PDMS)‐based silicone implants have been broadly used owing to their inert properties, biocompatibility, and low toxicity. However, long‐term implantation is usually associated with complications, such as capsular contracture due to excessive local inflammatory response, subsequently requiring implant removal. Therefore, modification of the silicone surface to reduce a risk of capsular contracture has attracted increasing attention. Human adipose‐derived stem cells (hASCs) are known to provide potentially therapeutic applications for tissue engineering, regenerative medicine, and reconstructive surgery. Herein, hASCs coating on a PDMS (hASC‐PDMS) or itaconic acid (IA)‐conjugated PDMS (hASC‐IA‐PDMS) surface is examined to determine its biocompatibility for reducing capsular contracture on the PDMS surface. In vitro cell cytotoxicity evaluation showed that hASCs on IA‐PDMS exhibit higher cell viability than hASCs on PDMS. A lower release of proinflammatory cytokines is observed in hASC‐PDMS and hASC‐IA‐PDMS compared to the cells on plate. Multiple factors, including in vivo mRNA expression levels of cytokines related to fibrosis; number of inflammatory cells; number of macrophages and myofibroblasts; capsule thickness; and collagen density following implantation in rats for 60 days, indicate that incorporated coating hASCs on PDMSs most effectively reduces capsular contracture. This study demonstrates the potential of hASCs coating for the modification of PDMS surfaces in enhancing surface biocompatibility for reducing capsular contracture of PDMS‐based medical devices.

show abstract