SERS biosensors based on cucurbituril-mediated nanoaggregates for wastewater-based epidemiology

Chio, Weng‐I Katherine; Xie, Huimin; Zhang, Yuewen; Lan, Yang; Lee, Tung‐Chun

doi:10.1016/j.trac.2021.116485

Cited by 30 publications

(20 citation statements)

References 55 publications

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“…Electrostatic interactions are another means of assembling metal nanoparticles on solid supports [ 78 ]. This can be achieved by employing polymers as adhesives, e.g., polyelectrolytes [ 79 ], polyvinyl pyrrolidone (PVP) [ 80 ], polyvinyl pyridine [ 81 ], and polystyrene [ 82 ].…”

Section: Applications Of Sers In Drug Detectionmentioning

confidence: 99%

Recent Advances in the Use of Surface-Enhanced Raman Scattering for Illicit Drug Detection

Azimi¹,

Docoslis²

2022

Sensors

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The rapid increase in illicit drug use and its adverse health effects and socio-economic consequences have reached alarming proportions in recent years. Surface-enhanced Raman scattering (SERS) has emerged as a highly sensitive analytical tool for the detection of low dosages of drugs in liquid and solid samples. In the present article, we review the state-of-the-art use of SERS for chemical analysis of illicit drugs in aqueous and complex biological samples, including saliva, urine, and blood. We also include a review of the types of SERS substrates used for this purpose, pointing out recent advancements in substrate fabrication towards quantitative and qualitative detection of illicit drugs. Finally, we conclude by providing our perspective on the field of SERS-based drug detection, including presently faced challenges. Overall, our review provides evidence of the strong potential of SERS to establish itself as both a laboratory and in situ analytical method for fast and sensitive drug detection and identification.

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Section: Applications Of Sers In Drug Detectionmentioning

confidence: 99%

Recent Advances in the Use of Surface-Enhanced Raman Scattering for Illicit Drug Detection

Azimi¹,

Docoslis²

2022

Sensors

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“…18 Moreover, the measured ring strain energy of CB [7] is the second lowest compared to other homologues because of the least deviation from the regular sp 3 methylene bridge bond angle upon ring formation (cyclization). 15,19 The relatively low "ring strain" energy ensures the stability of CB [7] and may explain the low yield of other CB[n] hosts. 15 It also should be noted that the volume of the internal cavity increases as more glycoluril units are incorporated in CB[n] analogues (Figure 1.2B), which determines their ability to bind specific types of guest molecules.…”

Section: Cucurbit[n]uril (Cb[n]) Family: Cucurbit[7]urilmentioning

confidence: 99%

“Click” Cucurbit[7]uril Hosts on Self-Assembled Monolayers: Quantitative Supramolecular Complexation with Ferrocene Guests

et al. 2022

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Cucurbit[7]uril (CB[7]), a symmetrical pumpkin-shaped molecule with an internal volume that can encapsulate guest molecules of complementary shape and size at a 1:1 ratio, has attracted tremendous attention in diverse fields. Particularly, the outstanding in-solution binding affinity (Kf  10 9 M -1 ) of the host-guest inclusion complexation between cucurbit[7]uril molecule host and ferrocene derivatives molecule guests (Fc@CB[7]) enables their potential applications as conjugation/immobilization motifs for constructing biosensors and other molecular devices. However, their interfacial host-guest complexation behaviour has been rarely studied, partially due to the limitation of current CB [7] surface immobilization strategies (suffering from either poor stability or time-consuming and inconvenient procedure). In this thesis, it was shown that the well-known copper(I)-catalyzed azide-alkyne cycloaddition "click" reaction (CuAAC) can be used to chemically attach alkyne-functionalized CB[7] onto an azide-terminated selfassembled monolayer (SAM) on gold. The reaction time has been reduced from several hours to 30 min compared to conventional methods (e.g., the olefin metathesis reaction or the thiol-ene "click" reaction). Thus prepared CB[7]-tethered SAMs enabled the determination of complexation properties of CB [7] towards various Fc derivatives (e.g., neutral, positively charged and negatively charged substituents) on the surface via conventional cyclic voltammetry measurements. Particularly, the derived complexation thermodynamics (Kf = (1.6 ± 0.3)  10 7 M -1 ) for ferrocenemethanol (FcMeOH), and kinetics data (ka = (2.6 ± 0.4)  10 3 M -1 s -1 , kd = (5.1 ± 0.3)  10 -5 s -1 ) confirms its strong interfacial host-guest binding with the surface-immobilized CB [7]. Moreover, the as-strong binding affinity of surface-bound CB[7] toward an anionic ferrocene derivative confirms the feasibility of employing Fc@CB[7] as the conjugation motif for immobilizing biological macromolecules (that are often negatively charged) to biochip surfaces.

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“…The rapid detection sensors for food toxins developed with MOFs are mainly based on three fundamental principles: (i) quenching luminous groups of MOFs such as the fluorescence and ultraviolet caused by the conjugated pi groups of ligands and lanthanide ion clusters ( Nong et al, 2020 ) (ii) capturing guest molecules by activated groups of MOFs or encapsulated constituents with further reactions (redox reaction and chromogenic reaction) and (iii) enhancing the spectral signals of target analytes located close to the plasmonic nanoparticles or nanostructured surfaces ( Yan et al, 2021 ; Chio et al, 2022 ). Therefore, the MOFs-based sensors employed in detecting food toxins can be divided into luminescent, electrochemical, colorimetric, and SERS sensors.…”

Section: Applications and Mechanisms Of Mofs-based Sensors In Toxins ...mentioning

confidence: 99%

Metal-Organic Frameworks-Based Sensors for the Detection of Toxins in Food: A Critical Mini-Review on the Applications and Mechanisms

Xuan

Wang

Manickam

et al. 2022

Front. Bioeng. Biotechnol.

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Using scientific technologies to detect toxins in food is significant to prevent food safety problems and protect people’s health. Recently, the rise of sensors has made rapid, efficient, and safe detection of food toxins possible. One of the key factors impacting the sensor’s performance is the nanomaterials employed. Metal-organic frameworks (MOFs), with high specific surface area, tunable composition, porous structure, and flexible properties, have aroused the interest of researchers. The applications of MOFs in detecting food toxins have seen remarkable success in the past few years. In this critical mini-review, the impact of various synthesis methods on MOFs’ properties is first presented. Then, the applications and mechanisms of MOFs-based sensors in detecting various toxins are summarized and analyzed. Finally, future perspectives, potential opportunities, and challenges in this field are discussed.

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SERS biosensors based on cucurbituril-mediated nanoaggregates for wastewater-based epidemiology

Cited by 30 publications

References 55 publications

Recent Advances in the Use of Surface-Enhanced Raman Scattering for Illicit Drug Detection

Recent Advances in the Use of Surface-Enhanced Raman Scattering for Illicit Drug Detection

“Click” Cucurbit[7]uril Hosts on Self-Assembled Monolayers: Quantitative Supramolecular Complexation with Ferrocene Guests

Metal-Organic Frameworks-Based Sensors for the Detection of Toxins in Food: A Critical Mini-Review on the Applications and Mechanisms

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