Sertaconazole Antifungal Profile Determined by a Microdilution Method versus Nine Topical Substances against Dermatophyte Fungi

Carrillo-Muñoz, Alfonso Javier; Tur-Tur, Cristina; Cárdenes, Delia; Rojas, Florencia; Giusiano, Gustavo

doi:10.1159/000345704

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…The MICs obtained in this study compared with the results of previous studies are provided in Table 2. Previously reported MIC 50 ranges for T. mentagrophytes-interdigitale of various antifungal drugs were similar to those observed in the present study (8,(19)(20)(21)(22). The MIC distributions of itraconazole, miconazole, luliconazole, voriconazole, ketoconazole, sertaconazole, naftifine, ciclopirox olamine, and clotrimazole show good susceptibility of T. mentagrophytes-interdigitale complex compared to terbinafine, fluconazole, and griseofulvin.…”

Section: Discussionsupporting

confidence: 90%

MIC and Upper Limit of Wild-Type Distribution for 13 Antifungal Agents against a Trichophyton mentagrophytes-Trichophyton interdigitale Complex of Indian Origin

Shaw

Singh

Dogra

et al. 2020

Antimicrob Agents Chemother

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Dermatophytosis due to the Trichophyton mentagrophytes-Trichophyton interdigitale complex is being increasingly reported across India. Reports of therapeutic failure have surfaced recently, but there are no clinical break points (CBP) or epidemiological cutoffs (ECVs) available to guide the treatment of dermatophytosis. In this study, a total of 498 isolates of the T. mentagrophytes-interdigitale complex were collected from six medical centers over a period of five years (2014 to 2018). Antifungal susceptibility testing of the isolates was carried out for itraconazole, fluconazole, ketoconazole, voriconazole, luliconazole, sertaconazole, miconazole, clotrimazole, terbinafine, amorolfine, naftifine, ciclopirox olamine, and griseofulvin. The MICs (in mg/liter) comprising >95% of the modeled populations were as follows: 0.06 for miconazole, luliconazole, and amorolfine; 0.25 for voriconazole; 0.5 for itraconazole, ketoconazole, and ciclopirox olamine; 1 for clotrimazole and sertaconazole; 8 for terbinafine; 16 for naftifine; 32 for fluconazole; and 64 for griseofulvin. A high percentage of isolates above the upper limit of the wild-type MIC (UL-WT) were observed for miconazole (29%), luliconazole (13.9%), terbinafine (11.4%), naftifine (5.2%), and voriconazole (4.8%), while they were low for itraconazole (0.2%). Since the MICs of itraconazole were low against the T. mentagrophytes-interdigitale complex, this could be considered the choice of first-line treatment. The F397L mutation in the squalene epoxidase (SE) gene was observed in 77.1% of isolates with a terbinafine MIC of ≥1 mg/liter, but no mutation was detected in isolates with a terbinafine MIC of <1 mg/liter. In the absence of CBPs, evaluation of the UL-WT may be beneficial for managing dermatophytosis and monitoring the emergence of isolates with reduced susceptibility.

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Section: Discussionsupporting

confidence: 90%

MIC and Upper Limit of Wild-Type Distribution for 13 Antifungal Agents against a Trichophyton mentagrophytes-Trichophyton interdigitale Complex of Indian Origin

Shaw

Singh

Dogra

et al. 2020

Antimicrob Agents Chemother

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“…Sertaconazole was reported to exhibit both fungistatic and fungicidal activities on the aforementioned species (Carrillo-Munoz et al, 2011).…”

Section: Microbiological Efficacy Of Npevs For the Treatment Of Onychmentioning

confidence: 99%

Novel nail penetration enhancer containing vesicles “nPEVs” for treatment of onychomycosis

et al. 2015

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Context: The systemic treatment of onychomycosis has been hampered by the reported side effects of antifungals in addition to the limited blood circulation to the affected nails. Topical ungual treatment would circumvent the limitations of systemic onychomycosis treatment. Objective: Preparation and characterization of nail penetration enhancer containing nanovesicles (nPEVs) loaded with sertaconazole for topical treatment of onychomycosis. Materials and methods: nPEVs were prepared using different nail penetration enhancers (N-acetyl-L-cysteine, thioglycolic acid, thiourea and ethanol) by the thin film hydration method, and characterized for their particle size, zeta potential, entrapment efficiency (EE%), elasticity, viscosity, physical stability and morphology. The selected nPEVs formula and the marketed Dermofix Õ cream were compared in terms of nail hydration, transungual drug uptake and antifungal activity against Trichophyton rubrum. Results: N-acetyl-L-cysteine was the optimum nail penetration enhancer for incorporation within vesicles. nPEVs showed high EE% of sertaconazole ranging from 77 to 95%, a size ranging from 38-538 nm and a zeta potential ranging from +48 to +72 mV. The selected nPEVs formula displayed spherical morphology and good storage stability. Compared to the conventional marketed cream, the selected nPEVs formula showed 1.4-folds higher hydration and drug uptake enhancement into nail clippings. Furthermore, it showed significantly higher zone of inhibition for Trichophyton rubrum (20.9 ± 0.25 mm) than the marketed cream (11.6 ± 0.44 mm). Conclusion: Nail penetration enhancer containing nanovesicles (nPEVs) present a very promising option, worthy of clinical experimentation on onychomycotic patients.

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Evaluación del perfil de sensibilidad in vitro de aislamientos clínicos de Trichophyton mentagrophytes y Trichophyton rubrum en Santiago, Chile

Jarabrán

González

Rodríguez

et al. 2015

Revista Iberoamericana de Micología

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Sertaconazole Antifungal Profile Determined by a Microdilution Method versus Nine Topical Substances against Dermatophyte Fungi

Cited by 4 publications

References 16 publications

MIC and Upper Limit of Wild-Type Distribution for 13 Antifungal Agents against a Trichophyton mentagrophytes-Trichophyton interdigitale Complex of Indian Origin

MIC and Upper Limit of Wild-Type Distribution for 13 Antifungal Agents against a Trichophyton mentagrophytes-Trichophyton interdigitale Complex of Indian Origin

Novel nail penetration enhancer containing vesicles “nPEVs” for treatment of onychomycosis

Evaluación del perfil de sensibilidad in vitro de aislamientos clínicos de Trichophyton mentagrophytes y Trichophyton rubrum en Santiago, Chile

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