Serum 25-hydroxyvitamin D and bone mineral density among Hispanic men

Araujo, Andre B.; Travison, Thomas G.; Esche, Gretchen R.; Holick, Michael F.; Chen, Thomas; McKinlay, John B.

doi:10.1007/s00198-008-0652-9

Cited by 18 publications

(12 citation statements)

References 54 publications

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“…In a study conducted in South Florida, vitamin D deficiency was more prevalent in Hispanics [32], although 25(OH)D levels were measured using a DiaSorin radioimmunoassay method. Recently, a study in a group of 358 Hispanic American men found the highest prevalence of vitamin D deficiency (<20 ng/ml or <50 nmol/l) among Puerto Ricans (26%), compared to those from the Dominican Republic (21%), Central America (11%) and South America (9%) [33]. Furthermore, recent data from the National Health and Nutrition Examination Survey, which measured 25(OH)D levels by a competitive binding protein assay, found vitamin D insufficiency (<30 ng/ml or <75 nmol/l) in 97% of non-Hispanic Blacks and 90% of Mexican Americans [34].…”

Section: Discussionmentioning

confidence: 99%

Determinants of Vitamin D Status among Overweight and Obese Puerto Rican Adults

Palacios¹,

Gil²,

Pérez³

et al. 2012

Ann Nutr Metab

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Background/Aims: Low vitamin D status is highly prevalent worldwide, and the major determinants are sun exposure and vitamin D intake. We aimed to measure vitamin D status in a sample of overweight/obese adults in Puerto Rico, an area with plenty of sun exposure, and relate it to vitamin D intake, sun exposure and body composition. Methods: Serum 25(OH)D levels (liquid chromatography-tandem mass spectrometry), body weight and fat (bioimpedance), vitamin D intake and sun exposure (questionnaires) were assessed. Analysis included age-adjusted correlations and multivariate regression. Results: In 98 subjects (66% females; 40–65 years), median serum 25(OH)D levels were 30.7 ng/ml (25–75th percentile 25.0–37.3); 55% had levels >30 ng/ml, 31% had levels between 20 and 30 ng/ml and 14% had levels <20 ng/ml. Total vitamin D intake was 180 IU/day (45–615), and the sun exposure score was 22 (17–27). After adjusting for gender, 25(OH)D levels were significantly correlated with vitamin D intake (r = 0.24, p = 0.018), the sum of sun exposure and vitamin D intake indices (r = 0.34, p = 0.001) and percent body fat (r = –0.25, p = 0.01). After adjusting for age, gender and percent body fat, the sum of sun exposure and vitamin D intake indices remained statistically associated with 25(OH)D levels (β = 1.5, p < 0.01). Conclusions: In this group of overweight and obese individuals, 25(OH)D was significantly related to vitamin D intake, sun exposure and vitamin D intake indices and percent body fat.

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Section: Discussionmentioning

confidence: 99%

Determinants of Vitamin D Status among Overweight and Obese Puerto Rican Adults

Palacios¹,

Gil²,

Pérez³

et al. 2012

Ann Nutr Metab

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“…Populations that shield themselves from solar exposure or who have pigmented skin are at increased risk for vitamin D deficiency [Looker et al, 2002]. Some of these groups may experience greater deleterious effects of low 25OHD levels on bone mineral density [Araujo et al, 2009]. In addition to these aforementioned effects in children and adults, there is increasing data that maternal vitamin D deficiency can affect in utero skeletal development.…”

Section: Clinical Skeletal Effects Of Vitamin Dmentioning

confidence: 99%

The biology and pathology of vitamin D control in bone

Bell

Demay

Burnett-Bowie

2010

J of Cellular Biochemistry

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Vitamin D is a steroid pro-hormone, whose active metabolite binds the vitamin D receptor (VDR) which, in turn, binds to DNA sequences on target genes as a heterodimer with the retinoid-X receptor, resulting in regulation of gene expression. The vitamin D pro-hormone can be synthesized in the skin, in response to ultraviolet radiation; however, dietary sources have become increasingly important as a result of cultural changes over the past few centuries. Based on its initial discovery as an anti-rachitic factor, studies of the role of vitamin D and its receptor have largely focused on the skeleton. Investigations into the pathophysiologic basis and therapeutic responses of skeletal disorders associated with impaired vitamin D action have led to the identification of the molecular pathways involved in hormone activation and regulation of gene expression by the liganded VDR. These studies have also demonstrated that the skeletal actions of the VDR and its ligand are largely redundant if normal mineral ion homeostasis can be maintained by other means. However, investigations in animal models with tissue-specific ablation of the VDR or the enzyme required for hormone activation have demonstrated novel actions in skeletal tissues. The active vitamin D metabolite has been shown to have both paracrine and endocrine actions in other tissues as well.

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“…10–15 Among 358 Hispanic-American men, the highest prevalence of vitamin D deficiency was found among those born in PR (26%), compared to those from the Dominican Republic (21%), Central America (11%), and South America (9%). 16 Recently, we found in a large sample of 2,293 adults in PR that 72% had vitamin D insufficiency (levels below 30 ng/ml) and 28% were vitamin D deficient. 17 …”

Section: Introductionmentioning

confidence: 99%

Inverse Association between Vitamin D Status and Diabetes in a Clinic Based Sample of Hispanic Adults in Puerto Rico

Ramos‐Trautmann

González

Díaz-Luquis

et al. 2015

Diabetes Res Open J

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Background Vitamin D deficiency is a public health problem around the world. Diabetes has been associated with vitamin D deficiency. We aimed to examine the association between the vitamin D status and diabetes in a clinic based sample of Hispanic adults in Puerto Rico. Methods Demographics and laboratory test results for serum 25(OH)D, Fasting Blood Glucose (FBG), and Haemoglobin A1C (HbAlc) were extracted from medical records. Vitamin D status was classified as deficient (<12 ng/ml); inadequate (12–20 ng/ml); insufficient (21–29 ng/ml) and optimal (≥30 ng/ml) using serum 25(OH)D levels. Results A total of 716 records were included in the analyses. Most were females (63.3%), with mean age of 54.1±14.9 y, mean BMI 30.1±6.3 kg/m2 and mean serum 25(OH)D levels of 24.3±8.6 ng/ml. Most were classified as diabetics (41.1%). Those with diabetes had lower 25(OH)D levels compared to pre-diabetic and normal glucose status (p<0.05). Serum 25(OH) D levels were inversely correlated to FBG and HbA1c in the total sample and in men (p<0.05). After adjusting for age, gender, BMI and seasonality, there was a greater risk of diabetes, but not prediabetes, in those with serum 25(OH)D levels <30 ng/ml. This risk increased from 1.8 times in those with vitamin D insufficiency to 4.2 times in those with vitamin D deficiency (<12 ng/ml). Conclusion Diabetes risk significantly increased as serum 25(OH)D levels decreased in this group of Hispanic adults, underscoring the importance of routinely screening high risk individuals for vitamin D deficiency and offer supplementation to normalize serum levels.

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Serum 25-hydroxyvitamin D and bone mineral density among Hispanic men

Abstract: Introduction-Disparities within ethnic groups are generally ignored, but in evolving populations they may have implications for public health. We examined ethnic variation in serum 25-hydroxyvitamin D [25(OH)D] and bone mineral density (BMD) among Hispanic American men.

Cited by 18 publications

References 54 publications

Determinants of Vitamin D Status among Overweight and Obese Puerto Rican Adults

Determinants of Vitamin D Status among Overweight and Obese Puerto Rican Adults

The biology and pathology of vitamin D control in bone

Inverse Association between Vitamin D Status and Diabetes in a Clinic Based Sample of Hispanic Adults in Puerto Rico

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