Serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children

Munawwarah, Laily; Evalina, Rita; Sofyani, Sri

doi:10.14238/pi57.5.2017.234-8

Cited by 4 publications

(3 citation statements)

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“…In children, 45% of AD cases first appeared at the age of 6 months, 60% appeared at the first year of age, and 8% first appeared before the age of 5 years. 9 , 10 In our study, it was found that there was more frequency in males, with an average age of 10 years.…”

Section: Discussionsupporting

confidence: 49%

Relationship of Substance P with the Degree of Atopic Dermatitis Severity

Paramita¹,

Nasution²,

Lubis³

2021

CCID

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Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disease that starts during childhood with a varied course. Itching or incessant itching in severe cases, sleep disturbance, and infection-prone skin are the typical symptoms of this disease. Substance P is postulated to have an important role in AD. Increasing levels of substance P in AD induce the release of IFN-γ, IL-4, tumor necrosis factor-α (TNF-α), and IL-10 from peripheral blood mononuclear leukocytes, inducing an itching response. Methods: This study is a cross-sectional study that aims to analyze the relationship between serum substance P levels and AD severity in children using Score of AD (SCORAD), and to determine the mean serum substance P levels and severity of AD in patients with AD. This study also aims to find out the correlation of substance P levels with the SCORAD values. Results: Forty-six children (29 males; 17 females) with a mean age of 10.35 years (standard deviation (SD) = 4.01) were diagnosed with AD. The SCORAD index assessment was conducted to analyze AD (mean value, 23.15; SD = 9.42), and mild AD obtained the highest degree. The level of substance P was also examined (mean value, 300.88; SD = 127.55). Discussion: This study did not find a significant relationship between substance P levels and AD severity (p-value = 0.880), and there was no significant correlation between substance P levels and SCORAD values (p-value = 0.233; r = −0.179). The limitations of this study include a small number of cases, no control group, and we only found two cases of severe AD. To generalize the results, further studies with wide range population and AD severity might be done in the future.

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Section: Discussionsupporting

confidence: 49%

Relationship of Substance P with the Degree of Atopic Dermatitis Severity

Paramita¹,

Nasution²,

Lubis³

2021

CCID

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“…Кроме того, отмечена отрицательная связь концентрации 25(ОН)D в сыворотке крови со степенью тяжести АтД. В частности, показано, что концентрация 25(ОН)D у больных со среднетяжелым и тяжелым АтД ниже, чем у больных с легким течением болезни [13,15,16]. Вместе с тем в ряде исследований ассоциацию концентрации 25(ОН)D со степенью тяжести АтД не обнаружили [17,18].…”

Section: обоснованиеunclassified

Association Between 25(ОН)D Concentration and Atopic Dermatitis and Its Severity Children Aged from 3 to 6 Years: Cross Sectional Study

Кашинская

Шахова

2021

Vopr. sovr. pediatr.

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Background. The association between the vitamin D provision for children and the atopic dermatitis (AD) development and severity is not clearly determined.Objective. The aim of the study was to compare 25(OH)D serum concentration in children with AD and in healthy peers with association analysis of 25(OH)D with disease severity and allergen sensibilization.Methods. The study included children aged from 3 to 6 years with AD and their healthy peers. Vitamin D provision was estimated via 25(OH)D serum concentration determined by chemiluminescent microparticle immunoassay. Vitamin D deficiency was established at 25(OH)D concentration 20 ng/ml, insufficiency — 21–29 ng/ml. Sensibilization to airborne (Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat epithelium and dandruff) and food (cow's milk and chicken egg proteins) allergens was determined by IgE concentration revealed via immunofluorescence.Results. The 25(OH)D serum concentration in children with AD (n = 106) was lower than in their healthy peers (n = 40), median (interquartile range) — 26.5 ng/ml (19.0–35.3) and 32.4 ng/ml (27.9–37.5) respectively (p = 0.012). Meanwhile, vitamin D insufficiency/deficiency according to 25(OH)D concentration was revealed in more than half patients (58%) with AD and in every third child (37%) from control group (OR — 3.5, 95% CI — 1.6–7.5). It was also revealed that 25(OH)D concentration was lower in patients with moderate course of AD (in comparison to mild) as well as in children sensibilized to airborne and/or food allergens.Conclusion. The vitamin D provision in preschool children is associated with AD, its severity and the presence of sensibilization to airborne and/or food allergens.

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“…The disorder severity can be assessed with the Scoring Atopic Dermatitis (SCORAD) index [ 8 ]. The SCORAD index consists of three criteria: (A) extent (percentage of skin surface affected according to the rule of nine); (B) intensity (incorporation of erythema, edema/papules, the outcome of itching, oozing/crust appearance, lichenification, and dryness, six parameters evaluated on a scale of 0–3; 0: absent, 1: mild, 2: moderate, 3: severe); and (C) subjective symptoms (for the last three days, the severity of pruritus, the impact of sleep, and the overall condition of the skin on daily life are questioned, and the responses are evaluated on a scale of 1 to 10) [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Impact of Serum Vitamin D Levels on the Scoring Atopic Dermatitis Index in Pediatric Atopic Dermatitis

Çiçek,

Köle

2023

Children

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Atopic dermatitis (AD) is a chronic and recurrent inflammatory skin condition characterized by itching, eczematous plaques, and dry skin. Despite ongoing research, its exact cause remains elusive. In this study, we aimed to explore the factors that influence the severity of AD in children and assess the relationship between serum vitamin D levels and the disease’s severity. We enrolled 96 AD patients in our investigation, evaluated their clinical condition using the Scoring Atopic Dermatitis (SCORAD) index, and compared them to a group of 90 healthy controls. Our analysis revealed that serum vitamin D levels and eosinophil counts significantly impacted the SCORAD index (p < 0.001). According to standardized regression coefficients, for each incremental unit in serum vitamin D levels, the SCORAD index exhibited a decrease of 0.449 units. Similarly, a one-unit increase in eosinophil count resulted in a 0.009 unit increase in the SCORAD index. It is worth noting that the influence of serum vitamin D levels on disease severity surpasses that of eosinophil counts and atopic conditions. In our patient cohort, we uncovered a negative correlation (r = −0.419, p < 0.001) between serum vitamin D levels and the SCORAD index. Our findings suggest that low serum vitamin D levels may have a more substantial impact on AD severity than atopic conditions and eosinophilia. Furthermore, we observed a negative association between the severity of AD and serum 25(OH)D3 levels.

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Serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children

Cited by 4 publications

References 10 publications

Relationship of Substance P with the Degree of Atopic Dermatitis Severity

Relationship of Substance P with the Degree of Atopic Dermatitis Severity

Association Between 25(ОН)D Concentration and Atopic Dermatitis and Its Severity Children Aged from 3 to 6 Years: Cross Sectional Study

Evaluation of the Impact of Serum Vitamin D Levels on the Scoring Atopic Dermatitis Index in Pediatric Atopic Dermatitis

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