Serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children

Munawwarah, Laily; Evalina, Rita; Sofyani, Sri

doi:10.14238/pi57.5.2017.965

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…A similar study performed in India also reported a significant negative correlation between the vitamin D serum level and SCORAD [28]. A previous study conducted on Indonesian children suggested a moderate correlation between the serum 25(OH)D level and the SCORAD index in children with AD [29]. In addition, randomized, double-blind, placebo-controlled trials demonstrated that vitamin D supplementation given to children with AD showed a significant improvement in the SCORAD index [30].…”

Section: Discussionmentioning

confidence: 80%

Vitamin D, cytokine profiles, and disease severity in infants with atopic dermatitis: a single centre, cross-sectional study

Barlıanto¹,

Wulandari²,

Sari³

et al. 2022

pdia

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Introduction: Atopic dermatitis (AD) is an immune-mediated inflammatory skin disease and generally develops in infancy. Studies evaluating the role of vitamin D in immune mechanims in AD showed varying results. Aim: To assess the association between serum vitamin D, cytokine profiles, and disease severity in infants with AD. Material and methods: A cross-sectional study was conducted on infants aged 0-12 months with AD in the Paediatric Allergy and Immunology Department, Saiful Anwar Hospital, Indonesia. The disease severity was assessed by the Scoring of Atopic Dermatitis (SCORAD) index. Blood was drawn to evaluate the total eosinophil count (TEC), total immunoglobulin E (tIgE), 25-hydroxyvitamin D (25(OH)D), interleukin-4 (IL-4), IL-17A, and IL-22 levels.Results: This study enrolled 36 infants including 19 with mild AD and 17 with moderate AD. Vitamin D deficiency and insufficiency were found in 18 (50%) and 9 (25%) subjects, respectively. The mean 25(OH)D level was lower and the mean IL-4, IL-17A, and IL-22 levels were higher in the moderate AD group than in the mild AD group (p < 0.05). A lower level of 25(OH)D was associated with a higher level of IL-17A (r = -0.315, p = 0.041). The SCORAD index was negatively correlated with 25(OH)D (r = -0.714, p < 0.001) and positively correlated with IL-17A (r = 0.522, p = 0.001) and IL-22 (r = 0.612, p < 0.001) but not IL-4 (r = 0.325, p = 0.053). Conclusions: There was a high prevalence of vitamin D deficiency and insufficiency in infants with AD, and a low vitamin D level was correlated with the severity of AD, dependently on IL-17A.

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Section: Discussionmentioning

confidence: 80%

Vitamin D, cytokine profiles, and disease severity in infants with atopic dermatitis: a single centre, cross-sectional study

Barlıanto¹,

Wulandari²,

Sari³

et al. 2022

pdia

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Association Between 25(ОН)D Concentration and Atopic Dermatitis and Its Severity Children Aged from 3 to 6 Years: Cross Sectional Study

Кашинская

Шахова

2021

Vopr. sovr. pediatr.

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Background. The association between the vitamin D provision for children and the atopic dermatitis (AD) development and severity is not clearly determined.Objective. The aim of the study was to compare 25(OH)D serum concentration in children with AD and in healthy peers with association analysis of 25(OH)D with disease severity and allergen sensibilization.Methods. The study included children aged from 3 to 6 years with AD and their healthy peers. Vitamin D provision was estimated via 25(OH)D serum concentration determined by chemiluminescent microparticle immunoassay. Vitamin D deficiency was established at 25(OH)D concentration 20 ng/ml, insufficiency — 21–29 ng/ml. Sensibilization to airborne (Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat epithelium and dandruff) and food (cow's milk and chicken egg proteins) allergens was determined by IgE concentration revealed via immunofluorescence.Results. The 25(OH)D serum concentration in children with AD (n = 106) was lower than in their healthy peers (n = 40), median (interquartile range) — 26.5 ng/ml (19.0–35.3) and 32.4 ng/ml (27.9–37.5) respectively (p = 0.012). Meanwhile, vitamin D insufficiency/deficiency according to 25(OH)D concentration was revealed in more than half patients (58%) with AD and in every third child (37%) from control group (OR — 3.5, 95% CI — 1.6–7.5). It was also revealed that 25(OH)D concentration was lower in patients with moderate course of AD (in comparison to mild) as well as in children sensibilized to airborne and/or food allergens.Conclusion. The vitamin D provision in preschool children is associated with AD, its severity and the presence of sensibilization to airborne and/or food allergens.

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Serum 25-hydroxyvitamin-D level and atopic dermatitis severity in children

Cited by 2 publications

References 11 publications

Vitamin D, cytokine profiles, and disease severity in infants with atopic dermatitis: a single centre, cross-sectional study

Vitamin D, cytokine profiles, and disease severity in infants with atopic dermatitis: a single centre, cross-sectional study

Association Between 25(ОН)D Concentration and Atopic Dermatitis and Its Severity Children Aged from 3 to 6 Years: Cross Sectional Study

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