Serum 25(OH) D in Diabetes Mellitus Type 2: Relation to Glycaemic Control

Al-Timimi, Dhia J.; Ali, Ardawan F.

doi:10.7860/jcdr/2013/6712.3733

Cited by 51 publications

(61 citation statements)

References 11 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found a significant weak negative correlation between HbA1C and 25(OH)D, similar to other previously published studies [12, 18, 23, 28, 33, 34]. However glycemic control was not associated with vitamin D when we controlled for confounding factors, as verified by Luo et al and Al-Shoumer et al [35, 36].…”

Section: Discussionsupporting

confidence: 91%

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Rolim¹,

Santos²,

Conceição³

et al. 2016

Diabetol Metab Syndr

View full text Add to dashboard Cite

ObjectivesDetermine the prevalence and identify predictors of hypovitaminosis D in patients with type 2 diabetes mellitus (T2DM); 2) correlate vitamin D levels with variables indicative of glycemic control and cardiovascular risk.Research design and methodsWe conducted a cross-sectional study with consecutive patients treated at a University Hospital’s Endocrinology outpatient clinic located at 12°58′S latitude, between October 2012 and November 2013. Hypovitaminosis D was defined as 25-hydroxyvitamin D < 30 ng/mL (chemiluminescence).ResultsWe evaluated 108 patients with mean duration of T2DM of 14.34 ± 8.05 years and HbA1c of 9.2 ± 2.1%. Mean age was 58.29 ± 10.34 years. Most were women (72.2%), non-white (89.8%) and had hypertension (75.9%) and dyslipidemia (76.8%). Mean BMI was 28.01 ± 4.64 kg/m2; 75.9% were overweight. The prevalence of hypovitaminosis D was 62%. In multiple logistic regression, independent predictors of hypovitaminosis D were female gender (OR 3.10, p = 0.02), dyslipidemia (OR 6.50, p < 0.01) and obesity (OR 2.55, p = 0.07). In multiple linear regression, only total cholesterol (β = −0.36, p < 0.01) and BMI (β = −0.21, p = 0.04) remained associated with levels of 25-hydroxyvitamin D.ConclusionsUsing currently recommended cutoffs, the prevalence of hypovitaminosis D in Brazilians with T2DM was as high as that of non-tropical regions. Female gender, dyslipidemia and obesity were predictors of hypovitaminosis D. Low levels of 25-hydroxyvitamin D were correlated with high cholesterol and BMI values. Future studies are needed to evaluate whether vitamin D replacement would improve these parameters and reduce hard cardiovascular outcomes.

show abstract

Section: Discussionsupporting

confidence: 91%

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Rolim¹,

Santos²,

Conceição³

et al. 2016

Diabetol Metab Syndr

View full text Add to dashboard Cite

show abstract

“…The HbA1c levels were uncontrolled in about 82% of patients enrolled in this study, and our results were in agreement with many studies which reported high HbA1c levels in T2DM …”

Section: Discussionsupporting

confidence: 93%

Estimation of magnesium level in type 2 diabetes mellitus and its correlation with HbA1c level

Saeed

Haj

Qasim

2018

Endocrino Diabet & Metabol

View full text Add to dashboard Cite

Summary Background Type 2 diabetes mellitus (T2DM) is a common disease; the total number of diabetes patients is expected to reach 366 million by 2030. Magnesium has received considerable attention for its potential role in improving insulin sensitivity and preventing diabetes and its cardiovascular complications. Hypomagnesaemia is linked to poor control of type 2 diabetes mellitus, and depletion of serum magnesium occurs exponentially with duration of disease. The aim of this study was to measure serum magnesium level and the correlation of magnesium level with HbA1c in type 2 diabetes mellitus. Methods In this cross‐sectional study, we included 100 diabetic patients; blood is taken for measurement of both magnesium and HbA1c levels. Patients with risk factors of magnesium deficiency were not included. Results Of the total 100 patients recruited in our study, majority had diabetes for 8.0 years duration. The mean age of the patients was 53.97 ± 10.65 years, most of them were on oral hypoglycaemic agents (84.9%) followed by combination of oral hypoglycaemic agents and insulin (10.5%), and a small percentage were on insulin alone (4.7%). The mean of serum magnesium and HbA1c levels was 1.88 ± 0.25 mg/dL and 8.38% ± 1.53%, respectively. The majority of the patients had a normal level of magnesium (95.0%); however, most of them had uncontrolled blood glucose (82.0%). The study showed that the serum magnesium level and HbA1c are not significantly correlated ( P = 0.462). Conclusion Normal magnesium levels were observed in majority of patients, there is no significant correlation between serum magnesium and HbA1c levels in patients with T2DM, but larger‐scale clinical trials are needed in future.

show abstract

“…Recently, there are compelling evidences suggesting that vitamin D deficiency might also play a significant role in the pathogenesis of type 2 diabetes mellitus 21,22 . Typically, serum 25(OH)D concentrations are low in type 2 diabetes patient 23 , particularly among those with poor glycemic control and long diabetes durations 24 Then it was observed that oral administration of 1, 25(OH) 2 D 3 completely protects NOD mice from insulin-dependent diabetes 29 . However, it is not known whether 1, 25(OH) 2 D 3 can actually inhibit β-cell apoptosis.…”

Section: A N U S C R I P Tmentioning

confidence: 98%

1, 25(OH)2D3 protects β cell against high glucose-induced apoptosis through mTOR suppressing

Zhou

Liu

et al. 2015

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

Serum 25(OH) D in Diabetes Mellitus Type 2: Relation to Glycaemic Control

Cited by 51 publications

References 11 publications

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Estimation of magnesium level in type 2 diabetes mellitus and its correlation with HbA1c level

1, 25(OH)2D3 protects β cell against high glucose-induced apoptosis through mTOR suppressing

Contact Info

Product

Resources

About