Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus

Abstract

IntroductionAdiponectin, leptin and resistin are adipokines that play important roles in the regulation of lipid and carbohydrate metabolism in type 2 diabetes (T2DM). However, their influence in type 1 diabetes mellitus is still unknown. The aim of this study was to measure serum adiponectin, leptin and resistin levels and to investigate their relationships with vitamin D and other clinical and laboratory parameters in patients with type 1 diabetes.Material and methodsFifty subjects with type 1 diabetes and 50 healthy age- and sex-matched subjects were selected from the Endocrinology Outpatient Clinic of Cairo University Pediatrics Hospital. Enzyme-linked immunosorbent assay was used to measure the levels of leptin, adiponectin and resistin. Vitamin D levels were measured using electro-chemiluminescence immunoassay.ResultsThere were no significant differences in adiponectin and leptin levels between diabetic and control subjects (p = 0.6 and p = 0.5 respectively). Resistin levels were significantly higher in the diabetic group compared to controls (p < 0.001) and in postpubertal patients compared to prepubertal patients (p < 0.04). Serum resistin in type 1 diabetes showed a negative correlation with vitamin D (p < 0.001) and a positive correlation with glycated hemoglobin (HbA1c) (p = 0.006), while other adipokines were not interrelated.ConclusionsThese results strongly support a role of resistin and vitamin D deficiency in the pathophysiology of type 1 diabetes. Vitamin D may be involved in resistin regulation through an unknown mechanism. Further studies are recommended to understand resistin regulation in type 1 diabetes.

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“…On the other hand, treatment intervention reduces resistin concentrations (especially on treatment with biologics and where a reduction in PASI of > 75% is achieved). This change in resistin concentrations (SMD 0·50 #bib95% CI 0·20–0·79) is expected to be of clinical importance as the effect is on the same magnitude reported between hypertensive and normotensive populations (SMD 0·85, 95% CI 0·15–1·54), as well as between hyperglycaemic and euglycaemic populations (mean difference 1·1 ± 1·3 ng dL −1 ) …”

Effects of a Watermelon Extract Beverage on Canine Lipid Metabolism and Urine Crystals

“…Adipokines, including leptin, adiponectin and resistin, are biologically active substances that are secreted mainly from mature adipose tissue, playing important roles in the regulation of the lipid and carbohydrate metabolism [11,12]. Because leptin primarily works as a fasting hormone thorough the regulation of food intake and energy consumption, plasma leptin levels are quantitative markers of obesity in humans, dogs and rodents [13,14].…”

“…It is known that adiponectin contributes to increased insulin sensitivity, reduced blood glucose and reduced tissue TG levels in the liver and muscle [14]. Resistin promotes inflammation and regulates the secretion of proinflammatory cytokines such as TNF-α and interleukin-6 (IL-6) [11][12][13][14][15]. However, there was only a slight change in adiponectin and no change in resistin over the study period.…”

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