Serum adiponectin and leptin levels in relation to the metabolic syndrome, androgenic profile and somatotropic axis in healthy non-diabetic elderly men

Gannagé‐Yared, Marie‐Hélène; Khalife, Simon; Semaan, Michelle; Fares, Florence; Jambart, S; Halaby, Georges

doi:10.1530/eje.1.02175

Cited by 120 publications

(103 citation statements)

References 67 publications

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“…In humans there appear to be relationships between the concentrations of adipokines and dyslipidemia (10,29). Gannag-Yared et al investigated the association between adiponectin and leptin with the markers of cardiometabolic syndrome including lipid concentrations, insulin sensitivity and steroid concentrations in healthy non-diabetic Lebanese men.…”

Section: Discussionmentioning

confidence: 99%

The Single Dose Poloxamer 407 Model of Hyperlipidemia; Systemic Effects on Lipids Assessed Using Pharmacokinetic Methods, and its Effects on Adipokines

Chaudhary

Brocks

2013

J Pharm Pharm Sci

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-Purpose:The induction of hyperlipidemia using poloxamer 407 (P407) is gaining use for studying the effect of the condition on drug pharmacokinetics. Although a single intraperitoneal dose of P407 causes a rapid onset of hyperlipidemia, the initial lipid concentrations are much higher than seen in humans. The hyperlipidemia is also reversible in nature. Here, pharmacokinetic methods were used to assess the P407 dose response on serum lipids, adipokines and cytokines. Methods: Single 0.5 and 1 g/kg doses of P407 were injected into rats followed by blood collection at various times for up to 12 d. Serum was assayed for lipids, selected adipokines and cytokines. Results: As expected, large increases in lipid levels were seen by 36 h after dosing. Using area under the concentration vs. time curve as a measure of systemic lipid exposure, P407 increased serum baseline corrected serum lipids in a nearly dose proportional fashion. The maximum increase in lipids was observed at ~36 h, with most lipids remaining elevated for up to ~180 h, although for the 1 g/kg dose triglyceride concentrations had still not quite returned to baseline by 12 days postdose. In addition to changes in lipids, P407 significantly increased serum leptin and decreased the serum adiponectin concentrations but did not affect cytokine levels. Conclusion: Depending on study aims, for the use of the model it may be beneficial to perform single-dose assessments at time points later than 36 h when the lipoprotein concentrations will be more similar to those seen in patient with hyperlipidemia.

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Section: Discussionmentioning

confidence: 99%

The Single Dose Poloxamer 407 Model of Hyperlipidemia; Systemic Effects on Lipids Assessed Using Pharmacokinetic Methods, and its Effects on Adipokines

Chaudhary

Brocks

2013

J Pharm Pharm Sci

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“…29,34,[45][46][47][48][49][50][51][52][53][54][55] Female data were compiled from 15 studies (26 groups of individuals), with study sample size ranging from 8 to 662 individuals and a mean sample size of 94. 29,45,46,48,50,[53][54][55][56][57][58][59][60][61][62] Lack of BMI-adiponectin association S-M Kuo and MM Halpern Among these studies, eight studies included subjects of both genders and the measurements from men and women were reported separately.…”

Section: Data Collectionmentioning

confidence: 99%

“…Some studies we compiled reported both plasma leptin and adiponectin measurements, thus allowing the correlation analysis between adiponectin and leptin. The regression analysis of male adiponectin to leptin was performed on data from seven groups 45,47,49,50,53,54 and Pearson's correlation was 0.53 (P40.05, not significant).…”

Section: Lack Of Bmi-adiponectin Association S-m Kuo and MM Halpernmentioning

confidence: 99%

Lack of association between body mass index and plasma adiponectin levels in healthy adults

Kuo

2011

Int J Obes

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Objectives: To test the hypothesis that obesity (increase in fat mass) independently affects the level of adipokines: adiponectin, tumor necrosis factor-a (TNFa) and interleukin (IL)-6. Methods: Publications in the past decade reporting adult plasma adiponectin, leptin, TNFa and/or IL-6 levels were compiled. Mean gender-specific values were extracted from studies that included medical screening to confirm physical health (43 groups, total 4852 subjects). Correlation analysis was conducted between adipokine levels and body mass index (BMI), a widely used estimate of adiposity. Results: For healthy lean to obese adults of both genders, no significant correlation between plasma adiponectin and BMI was detected. There was also no gender difference in plasma adiponectin level. In contrast, leptin levels showed a positive correlation with BMI in both genders, and women had significantly higher levels of plasma leptin consistent with a higher percentage of body fat. The proinflammatory cytokine TNFa failed to show correlation with BMI. Although IL-6 showed a positive correlation with BMI in women, the obesity-related increase was very limited. Conclusions: Data analysis based on studies performed on healthy adults did not support the hypothesis that obesity independently affects the plasma level of adiponectin and TNFa. Reported obesity-related changes in plasma adipokine levels may be a consequence of obesity-related metabolic disorders. Future studies are especially needed to understand the homeostasis of adiponectin.

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“…Chez l'homme, au contraire, l'hypotestostéronémie est plutôt associée à une adiposité exagérée, à une diminution de la sensibilité à l'insuline et à un syndrome métabolique [50,52]. Les hommes aux environs de la cinquantaine, obèses mais avec un phénotype MHO, ont un taux de testostérone sérique relativement plus élevé que les hommes obèses avec anomalies métaboliques [53].…”

Section: Rôle Contrasté Des Hormones Sexuellesunclassified

“…Les hommes aux environs de la cinquantaine, obèses mais avec un phénotype MHO, ont un taux de testostérone sérique relativement plus élevé que les hommes obèses avec anomalies métaboliques [53]. Les variations de la leptine et de l'adiponectine sont associées à celle des stéroïdes sexuels, et il a été proposé que la sex hormone binding globulin (SHBG) puisse être modulée par l'adiponectine [52]. Cette conclusion est confortée par une série de données expérimentales chez l'animal et par la démonstration que l'AD-36 est capable de promouvoir la différentiation préadipocytaire, de réduire l'expression et la sécrétion de leptine et de stimuler la captation de glucose par les cellules adipeuses, tout en augmentant l'expression de divers enzymes jouant un rôle clé dans la lipogenèse [55,56].…”

Section: Rôle Contrasté Des Hormones Sexuellesunclassified

Sujets « métaboliquement sains », bien qu’obèses. Première partie: diagnostic, physiopathologie et prévalence

Esser¹,

Paquot

Scheen

2009

Obes

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Résumé Environ 30 à 50 % des sujets obèses sont « métaboliquement normaux » (MHO pour metabolically healthy, but obese) alors qu'inversement, nombre de sujets non obèses sont « métaboliquement anormaux ». La topographie et la fonction des dépôts graisseux semblent jouer un rôle déterminant pour expliquer cet apparent paradoxe. Ce premier article vise à présenter les éléments conduisant au diagnostic du phénotype MHO, à tenter d'en cerner l'étiopathogénie et de mieux comprendre sa physiopathologie et, enfin, à analyser la prévalence de ce syndrome, quelque peu différente en fonction de la définition retenue et de la population étudiée.Mots clés : Adiposité viscérale; Obésité; Syndrome métabolique; Normalité métabolique Metabolically healthy, but obese subjects. First part: definition, pathophysiology and prevalence Abstract Around 30 to 50% of obese subjects are "metabolically normal" (MHO) whereas numerous non-obese subjects are "metabolically abnormal". The distribution and function of adipose deposits seem to play a crucial role in explaining this apparent paradox. The aim of this first article is to describe the clinical and biological characteristics that lead to the diagnosis of MHO, attempt to discover the etiopathogenesis of this syndrome and analyze the underlying pathophysiological mechanisms and, finally, to assess the prevalence of the MHO phenotype, which may vary according to the definition used and the population studied.

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Serum adiponectin and leptin levels in relation to the metabolic syndrome, androgenic profile and somatotropic axis in healthy non-diabetic elderly men

Cited by 120 publications

References 67 publications

The Single Dose Poloxamer 407 Model of Hyperlipidemia; Systemic Effects on Lipids Assessed Using Pharmacokinetic Methods, and its Effects on Adipokines

The Single Dose Poloxamer 407 Model of Hyperlipidemia; Systemic Effects on Lipids Assessed Using Pharmacokinetic Methods, and its Effects on Adipokines

Lack of association between body mass index and plasma adiponectin levels in healthy adults

Sujets « métaboliquement sains », bien qu’obèses. Première partie: diagnostic, physiopathologie et prévalence

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