Serum albumin/hyaluronic acid nanoconjugate: Evaluation of concentration-dependent structural changes to form an efficient drug carrier particle

Varga, Norbert; Serés, L.; Kovács, Nikolett Alexandra; Turcsányi, Árpád; Juhász, Ádám; Csapó, Edit

doi:10.1016/j.ijbiomac.2022.09.125

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…The pure drug and the drug-contained samples were placed separately in a cellulose (dialysis) membrane (M w cut-off = 14,000 Da; Sigma-Aldrich) with 5 mL buffer solution, which were inserted into 35 mL dissolution medium, and the penetration of the KP molecules was followed for 420 min. The dissolution curves were fitted by several kinetic equations (first order, second order, Higuchi, Weibull and Korsmeyer-Peppas models) using nonlinear regression [ 31 , 32 ] to provide more information on the release mechanism.…”

Section: Methodsmentioning

confidence: 99%

Core-Shell Structured PLGA Particles Having Highly Controllable Ketoprofen Drug Release

et al. 2023

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The non-steroid anti-inflammatory drug ketoprofen (KP) as a model molecule is encapsulated in different poly(lactide-co-glycolide) (PLGA) nanostructured particles, using Tween20 (TWEEN) and Pluronic F127 (PLUR) as stabilizers to demonstrate the design of a biocompatible colloidal carrier particles with highly controllable drug release feature. Based on TEM images the formation of well-defined core-shell structure is highly favorable using nanoprecipitation method. Stabile polymer-based colloids with ~200–210 nm hydrodynamic diameter can be formed by successful optimization of the KP concentration with the right choice of stabilizer. Encapsulation efficiency (EE%) of 14–18% can be achieved. We clearly confirmed that the molecular weight of the stabilizer thus its structure greatly controls the drug release from the PLGA carrier particles. It can be determined that ~20% and ~70% retention is available with the use of PLUR and TWEEN, respectively. This measurable difference can be explained by the fact that the non-ionic PLUR polymer provides a steric stabilization of the carrier particles in the form of a loose shell, while the adsorption of the non-ionic biocompatible TWEEN surfactant results in a more compact and well-ordered shell around the PLGA particles. In addition, the release property can be further tuned by decreasing the hydrophilicity of PLGA by changing the monomer ratio in the range of ~20–60% (PLUR) and 70–90% (TWEEN).

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Section: Methodsmentioning

confidence: 99%

Core-Shell Structured PLGA Particles Having Highly Controllable Ketoprofen Drug Release

et al. 2023

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“…For the preparation of the HyA-based carrier system (as hydrogels [6,7], microparticlegel systems [8], cell microcarriers [9], nanohydrogels [10], nanoemulsions [11], core-shell carriers [12], nanoconjugates [13], etc. ), the hydrophilic character of the polysaccharide needs to be modified, which can be achieved through cross-linking [14], chemical structural modifications [15], or electrostatic interactions [16]. Thanks to these methods of structural change, the encapsulation efficiency and the drug dissolution properties can be tuned, contributing to their usability in the field of biomedical research.…”

Section: Introductionmentioning

confidence: 99%

“…These neutralization methods are mainly driven by ionic interactions, and hydrophobic interactions presumably have importance as well [17], but the knowledge of these processes is still incomplete. Numerous HyA-macromolecule complexes have already been formed and studied [18], among which the most common ones are HyA-polymer (chitosan [19][20][21] and PEI [22]) and HyA-protein (zein [23], BSA [24], and HSA [16]) interactions. The obtained complexes are suitable for the delivery of small molecules, but the targeting of nucleic acids is also possible with them [25,26].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Concentration, Temperature, and pH on the Formation of Hyaluronic Acid–Surfactant Nanohydrogels

Serés

Csapó

Varga

et al. 2023

Gels

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The assembly of colloidal hyaluronic acid (HyA, as a polysaccharide) based hydrogel particles in an aqueous medium is characterized in the present paper, with an emphasis on the particular case of nanohydrogels formed by surfactant-neutralized polysaccharide networks. The structural changes and particle formation process of polysaccharide- and cationic-surfactant-containing systems were induced by the charge neutralization ability and the hydrophobic interactions of cetyltrimethylammonium bromide (CTAB) under different conditions. Based on the rheological, light scattering, ζ-potential, turbidity, and charge titration measurements, it can be concluded that the preparation of the HyA-CTAB particles can be greatly controlled. The results indicate that more available negative charges can be detected on the polymer chain at smaller initial amounts of HyA (cHyA < 0.10 mg/mL), where a molecular solution can be formed. The change in the pH has a negligible effect on the formation process (particle aggregation appears at nCTAB/nHyA,monomer~1.0 in every case), while the temperature dependence of the critical micelle concentration (c.m.c.) of CTAB determines the complete neutralization of the forming nanohydrogels. The results of our measurements confirm that after the appearance of stable colloidal particles, a structural change and aggregation of the polymer particles take place, and finally the complete charge neutralization of the system occurs.

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Effect of the Presence of Colloidal Gamma Globulin Nanocarrier for Sustained Carboplatin Release Enhancement: Preparation, Characterization, Drug Release and Efficacy Assessment

Mirzaei,

Saeidifar

2024

BioNanoSci.

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Serum albumin/hyaluronic acid nanoconjugate: Evaluation of concentration-dependent structural changes to form an efficient drug carrier particle

Cited by 5 publications

References 30 publications

Core-Shell Structured PLGA Particles Having Highly Controllable Ketoprofen Drug Release

Core-Shell Structured PLGA Particles Having Highly Controllable Ketoprofen Drug Release

The Effect of Concentration, Temperature, and pH on the Formation of Hyaluronic Acid–Surfactant Nanohydrogels

Effect of the Presence of Colloidal Gamma Globulin Nanocarrier for Sustained Carboplatin Release Enhancement: Preparation, Characterization, Drug Release and Efficacy Assessment

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