Serum albumin level accurately reflects antioxidant potentials in idiopathic nephrotic syndrome

Kaneko, Kazunari; Kimata, Takahisa; Shimo, Tomohiko; Takahashi, Masaya; Tanaka, Sachiyo

doi:10.1007/s10157-011-0578-y

Cited by 16 publications

(11 citation statements)

References 15 publications

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“…Polanco et al ( 30 ) found that the prognosis may be good in patients whose proteinuria reached 12 g/24 h. The present study did not find that proteinuria within the range of NS had any significant influence on the prognosis; however, the risk of end-point event occurrence in patients with serum albumin <25 g/l increased by 3.195-fold. Kaneko et al ( 31 ) identified that biological antioxidant potential (BAP) was closely correlated with the serum albumin concentration in patients with idiopathic nephrotic syndrome, and decreased BAP may aggravate the inflammatory response. Roche et al ( 32 ) also found that serum albumin is the most abundant antioxidant in the living body, and therefore hypoalbuminemia may reduce the ability of the body to repair oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the prognostic risk factors of idiopathic membranous nephropathy using a new surrogate end-point

et al. 2015

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Idiopathic membranous nephropathy (IMN) is one of the most common causes of nephrotic syndrome (NS) in adults. The latest study of the chronic kidney disease-prognosis consortium showed that a 30% decrease in the estimated glomerular filtration rate (eGFR) within 2 years could cover more patients and showed a better correlation with end-stage renal disease (ESRD), as compared with serum creatinine (SCr). The aim of the present study was to analyze prognostic factors of ESRD using a 30% decrease in eGFR within 2 years as the end-point. The medical records of patients who were diagnosed as having IMN by clinical pathology between February 2011 and August 2012 and had been followed up for ≥24 months were analyzed retrospectively. A 30% decrease in eGFR or the occurrence of ESRD were the end-points. Factors affecting the prognosis were analyzed by the χ2 test and multivariate logistic regression analysis, and the cumulative risk of risk factors was analyzed by Kaplan-Meier curve. A total of 73 patients with IMN were confirmed by clinical pathology. Blood pressure, tubulointerstitial injury area (TIA), glomerular sclerosis ratio, SCr, blood urea nitrogen, cystatin C, serum albumin and 24-h urine protein. In total, 28 patients (38.4%) reached the observation end-point. Multivariate logistic regression analysis showed that only age ≥60 years, serum albumin <25 g/l and TIA >25% were independent risk factors for predicting the occurrence of end-point events in the two groups (P<0.05), which increased the risk of the occurrence of end-point events in IMN patients by 3.471-, 3.195- and 6.724-fold, respectively. Kaplan-Meier curve showed that the occurrence of end-point events within 2 years was significantly higher in IMN patients whose age was ≥60 years, serum albumin <25 g/l and TIA >25% (log-rank P=0.004, P=0.024 and P=0.001). The results of the present study revealed that age ≥60 years, low serum albumin concentrations and severe tubulointerstitial injury are independent risk factors for the occurrence of ESRD in IMN patients.

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Section: Discussionmentioning

confidence: 99%

Analysis of the prognostic risk factors of idiopathic membranous nephropathy using a new surrogate end-point

et al. 2015

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“…Albumin is a routine marker reflecting both nutritional status and systemic inflammation, while the synthesis of albumin can be suppressed by systematic inflammation and malnutrition. Recent studies have demonstrated that serum albumin functions as an antioxidant in the host defense mechanism . The ALB‐dNLR (albumin‐dNLR) score consists of the serum albumin and derived neutrophil to lymphocyte ratio, indicating nutritional status and inflammatory conditions that are associated with the disease activity of RA patients, while there is no investigation about the associations between ALB‐dNLR score and disease activity in RA patients.…”

Section: Introductionmentioning

confidence: 99%

The association between albumin‐dNLR score and disease activity in patients with rheumatoid arthritis

Chen

et al. 2018

Clinical Laboratory Analysis

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Background Recently, clinical studies have described an association between albumin and the derived neutrophil to lymphocyte ratio (dNLR) with several diseases. This study was aimed to investigate the albumin‐dNLR (ALB‐dNLR) score in rheumatoid arthritis (RA) patients and assess its relationship with clinical and laboratory parameters of RA. Methods We retrospectively enrolled 127 RA patients, 155 osteoarthritis (OA) patients, and 155 healthy controls. The ALB‐dNLR score was based on serum albumin level, neutrophil count, and white cell count. The Spearman's rank test was used to measure the correlations between ALB‐dNLR score and disease activity as well as laboratory indexes. Results The ALB‐dNLR score was significantly higher in RA patients than in OA patients (P < 0.001) and in healthy controls (P < 0.001). The proportion of higher ALB‐dNLR score has been raised along with increased disease activity (P < 0.001). The Spearman's rank test showed that ALB‐dNLR score was positively associated with DAS28 score, CRP, ESR, IgA, and platelet count. Moreover, the receiver operating characteristic (ROC) curve showed that the area under the curve (AUC) of ALB‐dNLR was 0.693 (95% CI: 0.631‐0.755), which was higher than that of albumin (AUC: 0.625, 95% CI: 0.559‐0.692) and dNLR (AUC: 0.680, 95% CI: 0.617‐0.743) alone. Conclusions The results demonstrate that the ALB‐dNLR score increased in RA patients. The ALB‐dNLR score may be a useful marker to estimate the disease activity of RA patients.

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“…In addition, serum albumin levels showed a significant negative association with high d-ROM levels in men, but not in women. Although a relationship between albumin and BAP has been reported in general population [27] and in patients with nephrotic syndrome [35], a relationship between albumin and d-ROMs in men has not been demonstrated previously. What causes the gender difference in the association between serum albumin and d-ROMs should be assessed in future studies.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Serum Uric Acid and Serum Oxidative Stress Markers in the Japanese General Population

Ishizaka

Yamakado²,

Toda³

et al. 2014

Nephron Clin Pract

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Background: Increased production of reactive oxygen species is a condition that is associated with, and plays a role in the progression of, various disorders such as hypertension, atherosclerosis, and diabetes. Purpose: To assess in vivo oxidative stress levels and antioxidant potential and to analyze the relationship with serum uric acid (UA) levels. Methods and Results: Oxidative stress levels (derivatives of reactive oxygen metabolites, d-ROMs) and antioxidant potential (biological antioxidant potential, BAP) were measured in individuals who underwent a general health screening test, and data were analyzed from 8,025 individuals (2,953 women and 5,072 men) who were free from UA-lowering medication. Higher serum UA levels were associated with increased levels of d-ROMs in both genders, and this trend was more prominent in women. In addition, higher UA levels were also associated with higher BAP in both genders, although the dose dependence was not apparent in men. These associations remained statistically significant after adjusting for age, blood pressure, renal function, albuminuria, C-reactive protein, and insulin resistance index. Conclusions: In individuals who underwent general health screening, serum UA levels were positively associated with both d-ROMs and BAP levels. Whether lowering of UA by lifestyle modification or by medication alters d-ROM/BAP levels awaits further investigations.

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Serum albumin level accurately reflects antioxidant potentials in idiopathic nephrotic syndrome

Abstract: Our results suggest that decreased antioxidant potentials caused by hypoalbuminemia in INS may contribute to an aberrant immunity.

Cited by 16 publications

References 15 publications

Analysis of the prognostic risk factors of idiopathic membranous nephropathy using a new surrogate end-point

Analysis of the prognostic risk factors of idiopathic membranous nephropathy using a new surrogate end-point

The association between albumin‐dNLR score and disease activity in patients with rheumatoid arthritis

Relationship between Serum Uric Acid and Serum Oxidative Stress Markers in the Japanese General Population

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