Serum ALT: LDH ratio in typhoid fever and acute viral hepatitis

Balasubramanian, Sundaram; Kaarthigeyan, K; Srinivas, S.; Rajeswari, R.

doi:10.1007/s13312-010-0064-8

Cited by 21 publications

(15 citation statements)

References 4 publications

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“…The elevated serum LDH levels have been reported to be the diagnostic markers of various illnesses in humans, including the life-threatening bacterial infection 10 . The report on LDH isoforms analysis has, however, been scanty 6 .…”

Section: Resultsmentioning

confidence: 99%

“…The LDH has been studied as a diagnostic marker of noninfectious 7-9 as well as infectious diseases, including bacterial infection 6,10 . The infection with bacterial pathogens including group A streptococci causes a number of diseases, in humans, with multiple organs involvement and tissue damages leading to the secretion of LDH releasing into the blood 6 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lactate Dehydrogenase Isoenzyme Profiles in Group a Streptococcal Infection

Ghosh¹,

Mandal²,

Mandal³

2017

Int. Res. J. Pharm.

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The serum lactate dehydrogenase isoforms analysis and estimation are useful in the determination of pathogenic infection. This study explores the possible association between serum lactate dehydrogenase level and group A streptococci (also called Streptococcus pyogenes) infection compared to the healthy controls, and determines the lactate dehydrogenase isoenzyme patterns in group A streptococci infection. The serum samples procured from blood of group A streptococci infection (anti-Streptolysin O positive) cases as well as from the normal individuals were processed for lactate dehydrogenase estimation, and the results were expressed as mean  SD; the lactate dehydrogenase levels of ≤320 IU/L were considered normal. The all serum samples from group A streptococci infection cases and the healthy controls were subjected to polyacrylamide gel electrophoresis analysis for lactate dehydrogenase isoforms. In group A streptococcal infection cases, the lactate dehydrogenase values were 729.86  161.46 IU/L (range: 482 -862 IU/L) for males, and 455.75  74.60 IU/L (range: 370 -540 IU/L) for females, while among the normal groups the lactate dehydrogenase values ranged from 152.80  32.46 IU/L (for males) to 160.75  40.33 IU/L (for females). A significant increase in lactate dehydrogenase levels in group A streptococcal infection cases was observed, when compared with healthy controls (p value: <0.01). Based upon the staining intensity, the increased levels of lactate dehydrogenase1, lactate dehydrogenase2 and lactate dehydrogenase3 isoforms have evidently been proved. Therefore, the total serum lactate dehydrogenase and the individual lactate dehydrogenase isoforms might be useful in the diagnosis of group A streptococci infection.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lactate Dehydrogenase Isoenzyme Profiles in Group a Streptococcal Infection

Ghosh¹,

Mandal²,

Mandal³

2017

Int. Res. J. Pharm.

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“…The elevated serum LDH levels have been reported to be the diagnostic markers of various illnesses in humans, including the life-threatening bacterial infection [32]. This study demonstrated the serum LDH profiles in dengue cases as well as non-dengue subjects, first time, within and around Malda, India, in order to confirm the intensity of LDH bands in the stained gel ( Figure 4), from PAGE system, with the estimated levels of serum LDH in cases as well as non-dengue individuals.…”

Section: Resultsmentioning

confidence: 99%

Diagnosis of Dengue Infection Cases by Serum Lactate Dehydrogenase Profiling Compared to Dengue NS1 Antigen and Anti-dengue IgM Antibody Detection: A Retrospective Study

Mandal¹,

Ghosh²,

Halder³

et al. 2018

acta scient microb

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The serum LDH (lactate dehydrogenase) levels have been reported to be increased in DF, and studies showed that LDH levels are higher in DHF and DSS cases [7], while an early elevation of LDH was recorded as an independent predictor of DHF [8]. As per the report of Perveen., et al. [9], at the time of hospital stay, patients having DHF had higher level of LDH, compared to the patients with DF. The LDH level was found to be increased in dengue cases (563 U/L), compared to normal individuals (160 -320 U/L), as has been reported by Shameemunnisa and Jenith [10]. Thus, the higher serum LDH levels have been considered to be the diagnostic markers Dengue, which is a mosquito-borne disease vectored principally AbstractKeywords: Dengue; NS1 Antigen; Anti-DENV IgM Antibody; ELISA; Serum Lactate Dehydrogenase; PAGE Analysis Dengue is an acute infection with potential fatal complications; the specific antibody detection for which is an indirect method, and the novel parameter NS1 is reliable for diagnosis of dengue infection, while the serum LDH has been reported to be elevated in severe dengue. This study attempts to evaluate the association of serum LDH with NS1 antigen and IgM in dengue. The serum NS1and IgM of dengue cases, by ELISA, were estimated from index values by dividing absorbance at 450 nm with cut-off values. Total LDH was measured using autoanalyzer. Electropherotyping of LDH was done in 7.5% polyacrylamide gels. The NS1 and IgM parameters were compared with LDH levels, and analyzed statistically. The NS1 antigens were 35.23 ± 5.37 U (normal < 9 U) with 634.67 ± 350.55 U/L LDH (normal ≤250 U/L) (r = -0.57) among 32.33 ± 7.13 years patients and IgM antibodies were 52.38 ± 7.68 U with 451.67 ± 119.74 U/L LDH (r = -0.13) among 25.92 ± 5.01 years patients. The electropherotype showed intense and greater band pattern when IgM was detected compared to NS1 antigen. Appearance of dengue NS1 antigen as well as anti-dengue IgM in the early phase of infection was inversely related to the level of serum LDH, and increased LDH activity was found when IgM was detected.Thus, LDH might be useful as predictive tool in the early course of dengue infection.

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“…[2,6] In children, serum aminotransferase levels are markedly elevated in viral hepatitis (8-10 times normal) as compared to typhoid hepatitis, and the ratio of AST/LDH is more than 9 in viral hepatitis. [2,7,8] Balasubramanian et al found that, on admission, children with typhoid hepatitis had ALT: LDH values below 9, and those with an acute viral hepatitis had the values above 9. [7] Other differentiating clinical features in typhoid fever include high grade fever, toxic appearance, relative bradycardia, relative lymphocytosis with leucopenia and an absence of deep jaundice.…”

Section: Discussionmentioning

confidence: 99%

“…[2,7,8] Balasubramanian et al found that, on admission, children with typhoid hepatitis had ALT: LDH values below 9, and those with an acute viral hepatitis had the values above 9. [7] Other differentiating clinical features in typhoid fever include high grade fever, toxic appearance, relative bradycardia, relative lymphocytosis with leucopenia and an absence of deep jaundice. [6] The coagulation profile is usually normal in typhoid fever even in the presence of elevated hepatic enzymes.…”

Section: Discussionmentioning

confidence: 99%

Co-existence of typhoid fever and hepatitis A

Zaki

Shanbag

2012

Ann Trop Med Public Health

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Typhoid fever and viral hepatitis are endemic in many developing countries. Both are transmitted by the feco-oral route and are associated with poor sanitation. Co-existence of both the infection is possible posing a diagnostic dilemma for the treating physician. We report a 7-year-old boy, who had co-existent typhoid fever and hepatitis A infection and was managed successfully. An aim of this report is to discuss the clinical scenario and presentation when typhoid fever and hepatitis A occur concurrently in a patient.

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Serum ALT: LDH ratio in typhoid fever and acute viral hepatitis

Cited by 21 publications

References 4 publications

Lactate Dehydrogenase Isoenzyme Profiles in Group a Streptococcal Infection

Lactate Dehydrogenase Isoenzyme Profiles in Group a Streptococcal Infection

Diagnosis of Dengue Infection Cases by Serum Lactate Dehydrogenase Profiling Compared to Dengue NS1 Antigen and Anti-dengue IgM Antibody Detection: A Retrospective Study

Co-existence of typhoid fever and hepatitis A

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