Serum Amyloid A Levels Are Increased in Pre-Eclampsia

Engin-Üstün, Yaprak; Üstün, Yusuf; Karabulut, Aysun Bay; Ozkaplan, Esra; Meydanlı, Mehmet Mutlu; Kafkaslı, Ayşe

doi:10.1159/000100329

Cited by 21 publications

(19 citation statements)

References 21 publications

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“…A recent pilot study published in Gynecologic and Obstetric Investigation indicated increased levels of SAA in preeclampsia [15] ; however, in this first larger study of SAA levels in preeclampsia, SAA levels were not increased compared to either normal pregnancy levels or non-pregnant levels. CRP levels in women with preeclampsia were not elevated either, despite the higher pre-pregnancy BMI in these women.…”

Section: Discussioncontrasting

confidence: 66%

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Serum Amyloid A Protein and C-Reactive Protein in Normal Pregnancy and Preeclampsia

Kristensen¹,

Wide‐Swensson²,

Lindström

et al. 2009

Gynecol Obstet Invest

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Aims: To study plasma levels of serum amyloid A protein and C-reactive protein in pregnant women with and without preeclampsia and non-pregnant women. Plasma levels of haptoglobin, orosomucoid and ceruloplasmin were also analyzed. Methods: The study included 295 women with uncomplicated pregnancies, 57 women diagnosed with preeclampsia, and 58 healthy non-pregnant women. Plasma concentrations of acute phase proteins were analyzed by particle-enhanced immunoassays. Non-parametric Kruskal-Wallis and Mann-Whitney U tests were used to test differences between the groups. Results: Plasma levels of C-reactive protein and ceruloplasmin were increased in pregnant women with and without preeclampsia compared to non-pregnant women. Plasma levels of serum amyloid A protein and C-reactive protein were not elevated in women with preeclampsia compared to women with normal pregnancy. Conclusion: The description of preeclampsia as a systemic inflammatory state was not reflected in the plasma levels of serum amyloid A protein and C-reactive protein.

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Section: Discussioncontrasting

confidence: 66%

“…The level of SAA, the other major acute phase protein, has previously been found to be unaltered by pregnancy. In a recent pilot study, the SAA level was found to be increased in women with preeclampsia correlating with other proinflammatory cytokines [15] .…”

mentioning

confidence: 94%

Serum Amyloid A Protein and C-Reactive Protein in Normal Pregnancy and Preeclampsia

Kristensen¹,

Wide‐Swensson²,

Lindström

et al. 2009

Gynecol Obstet Invest

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“…SAA levels have been shown to be increased in pregnant women with preeclampsia compared with controls (47). Although the animal model used was not optimal for the study of preeclampsia or IU growth retardation, conditions that are associated with PTL, it is interesting to speculate if SAA may be a marker for other obstetrical complications that result in premature delivery.…”

Section: Discussionmentioning

confidence: 99%

Plasma Biomarkers in a Mouse Model of Preterm Labor

et al. 2009

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Preterm labor (PTL) is frequently associated with inflammation. We hypothesized that biomarkers during pregnancy can identify pregnancies most at risk for development of PTL. An inflammation-induced mouse model of PTL was used. Surfaceenhanced laser desorption/ionization time-of-flight mass spectrometry was used to analyze and compare the plasma protein (PP) profile between CD-1 mice injected intrauterine with either lipopolysaccharide (LPS) or PBS on d 14.5 of gestation. The median differences of normalized PP peaks between the two groups were determined using the Mann-Whitney U test and the false discovery rate. In a second series of experiments, both groups of mice were injected with a lower dose of LPS. A total of 1665 peaks were detected. Thirty peaks were highly differentially expressed (p Ͻ 0.0001) between the groups. Two 11 kDa protein peaks were identified by MALDI-TOF/TOF-MS and confirmed to be mouse serum amyloid A (SAA) 1 and 2. Plasma SAA2 levels were increased in LPS-treated animals compared with controls and in LPS-treated animals that delivered preterm vs. those that delivered at term. SAA2 has the potential to be a plasma biomarker that can identify pregnancies at risk for development of PTL. (Pediatr Res 66: 11-16, 2009) P reterm birth is the most important cause of neonatal morbidity and mortality in the United States (1-3). Despite several interventions including use of various tocolytics, antibiotics, and monitoring uterine contractions the incidence of preterm birth in the United States has not decreased in the past few decades and is currently at 12.7% (4,5) (Births. Preliminary data for 2005 http://www.cdc.gov/nchs/). More recently, the use of progesterone has been shown to be effective in prevention of preterm labor (PTL) in a select group of women. However, the mechanism by which this occurs is still unknown (6,7). One of the problems in preventing PTL is our inability to accurately identify which pregnancies are most likely to be complicated by PTL (8). Detection of a biomarker during pregnancy may assist in identifying an at risk population of pregnant women in whom a particular treatment can be studied. It can also help us gain important insights into the molecular pathways resulting in PTL.There is strong evidence to suggest that intrauterine (IU) infection or inflammation has a strong association with preterm delivery (3,9 -11). It is estimated that an overt or subclinical IU inflammation is present in close to 25-75% of births that result from spontaneous PTL (12,13). The timing of onset of IU inflammation and whether these markers of inflammation are present in the plasma is unknown. A sensitive diagnostic marker identified in early pregnancy may assist in early application of preventive therapies for women at risk for developing PTL.Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF/MS) is a high throughput proteomics technology that has been used for discovery of potential biomarkers of diseases (14 -22).In this study, we used a m...

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“…The pathophysiology of preeclampsia is not yet fully elucidated and may include abnormal physiologic transformation of the spiral arteries, intravascular inflammation, endothelial cell dysfunction, excessive thrombin generation, oxidative stress and/or antiangiogenic state [2,4,5]. The role of oxidative stress in the pathophysiology of preeclampsia has increasingly been postulated.…”

Section: Introductionmentioning

confidence: 99%