Serum and exhaled breath condensate leptin levels in asthmatic and obesity children: a pilot study

Bodini, Alessandro; Tenero, Laura; Sandri, Marcus; Maffeis, Claudio; Piazza, Michele; Zanoni, Laura; Peroni, Diego; Boner, Attilio; Piacentini, G

doi:10.1088/1752-7163/aa61c5

Cited by 17 publications

(14 citation statements)

References 35 publications

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“…In the case of children, Guler et al [93] also found a positive relationship between asthma and leptin serum levels. Bodini et al [94] measured the level of leptin in serum and exhaled breath condensate (EBC) in 61 asthmatic and non-asthmatic children from 6 to 14 years old. Those authors also considered the obese and non-obese status based on the BMI.…”

Section: Pro-inflammatory Adipokines: Leptin and Resistinmentioning

confidence: 99%

Diet: A Specific Part of the Western Lifestyle Pack in the Asthma Epidemic

Frontela‐Saseta

González-Bermúdez

García‐Marcos

2020

JCM

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The Western lifestyle is a complex concept that includes the diet as the main axis of different factors which contribute to a detrimental effect on health, lower life expectancy and low quality-of-life. This type of diet is characterized by being high in calories, mainly provided by saturated fats, and rich in sugars that can lead to changes in immune cells and their responsiveness, by different mechanisms that have yet to be totally clarified. Inflammatory processes are perpetuated through different pathways, in which adipose tissue is a major factor. High fat stores in overweight and obesity accumulate energy but the endocrine function is also producing and releasing different bioactive compounds, adipokines, known to be pro-inflammatory and which play an important role in the pathogenesis of asthma. This review therefore explores the latest evidence regarding the adverse effect of the Western diet on adipose tissue inflammation and its causative effect on the asthma epidemic.

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Section: Pro-inflammatory Adipokines: Leptin and Resistinmentioning

confidence: 99%

Diet: A Specific Part of the Western Lifestyle Pack in the Asthma Epidemic

Frontela‐Saseta

González-Bermúdez

García‐Marcos

2020

JCM

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“…Besides, leptin can promote the production of leukotrienes, increase the secretion of immune factor immunoglobulin E, and elevate the expression of inflammatory mediators, thus leading to airway inflammatory response. 20 The shortcoming of this study was that our preliminary data should be further validated with a large number of samples and the exact mechanism pathway of adiponectin and leptin to exacerbate the asthma has not been determined, and it will be the emphasis in subsequent research.…”

Section: Discussionmentioning

confidence: 99%

Correlations of severity of asthma in children with body mass index, adiponectin and leptin

Wang

Xue

2019

Clinical Laboratory Analysis

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BackgroundThis study aims to investigate the correlations of asthma in children with body mass index (BMI), adiponectin, and leptin.MethodsA total of 122 children with asthma in our hospital from January 2017 to February 2018 were randomly selected and divided into control group (normal) and observation group (BMI > 28 kg/m2) according to BMI. BMI, adiponectin, and leptin levels between the two groups were measured and compared, and correlations of disease grade with BMI, adiponectin, or leptin were analyzed. Moreover, risk factors for asthma in children were also identified.ResultsBody mass index, leptin level, forced vital capacity (FVC), FVC%, and forced expiratory volume in 1s (FEV1)/FVC in observation group were significantly higher than those in control group (P < 0.05), while the adiponectin level, forced expiratory capacity in 1s (FEC1), and FEV1% in observation group were significantly lower than those in control group (P < 0.05). The amount of severe patients in observation group was much larger than that in control group. The severity of disease was positively correlated with BMI and leptin and negatively correlated with adiponectin. BMI, adiponectin, and leptin were identified as risk factors for asthma in children.ConclusionAdiponectin, leptin, and BMI are involved in the pathogenesis of asthma in children, suggesting they might be therapeutic targets for clinical treatment.

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“…Clinical researches also showed that the levels of leptin in EBC from asthmatic children were significantly higher than normal children. 30 On the other hand, adiponectin, another important adipokine produced by adipocytes, is significantly decreased in obese subjects. Conversely, weight loss promotes an increase on adiponectin levels.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Newson and colleagues 12 found that leptin and leptin/adiponectin ratio were positively associated with the severity of asthma according to a clinical follow-up survey. Besides, through evaluating the levels of leptin in exhaled breath condensate (EBC) from asthmatics, normal and overweight children, Bodini et al 13 found that EBC-leptin levels are significantly higher in the obese subjects and in asthmatic ones compared with healthy subjects. Therefore, leptin might translocate to the airway and play a role on the airway inflammation.…”

Section: Introductionmentioning

confidence: 99%

Expression Levels of Predominant Adipokines and Activations of STAT3, STAT6 in an Experimental Mice Model of Obese Asthma

Lei

Liu

Zhu

et al. 2019

IJAAI

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Obese asthma is a new asthma phenotype. The underlying mechanisms are not clearly understood. Leptin and adiponectin are two predominant adipokines produced by adipose tissue. Studies have demonstrated a role of leptin on regulating the Janus kinase/signal transducer and ativator of transcription protein (JAK/STAT) signaling pathway and STAT3, STAT6 were known to have essential role on inflammatory cytokines production. However, whether STAT3 and STAT6 are activated and related to leptin merit further investigation. The aim of this study was to investigate the expression levels of leptin/adiponectin ratio and the activations of STAT3 and STAT6 in the lungs of obese asthma mice. Experiments were carried out on male C57/B6J mice. The proteins in bronchoalveolar lavage fluid (BALF) were measured using ELISA. The expression levels of the transcriptional and translational factors in the lungs were examined using Quantitative Reverse Transcriptase Polymerase Chain reaction (qRT-PCR) and western blot. The expression levels of leptin in the BALF of normal weight group, asthma group, obese group and obese asthma group were 2.032±0.133, 5.375±0.123, 5.418±0.165 and 7.486±0.168, respectively. The expression of leptin in obese asthma group was the highest (p<0.05) ，while the expression of adiponectin the lowest (p<0.05). The expression level of P-STAT3 in the obese asthma group was 0.9244±0.014, and was significantly higher than three other groups (p<0.05). The expressions of P-STAT6 in three other groups were all significantly higher than normal weight group (p<0.05). Our data suggest that the function of leptin on the pulmonary inflammation of obese asthma may be partly through activating the STAT3 signaling pathway.

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Serum and exhaled breath condensate leptin levels in asthmatic and obesity children: a pilot study

Cited by 17 publications

References 35 publications

Diet: A Specific Part of the Western Lifestyle Pack in the Asthma Epidemic

Diet: A Specific Part of the Western Lifestyle Pack in the Asthma Epidemic

Correlations of severity of asthma in children with body mass index, adiponectin and leptin

Expression Levels of Predominant Adipokines and Activations of STAT3, STAT6 in an Experimental Mice Model of Obese Asthma

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