Serum and intracellular magnesium deficiency in patients with metabolic syndrome—Evidences for its relation to insulin resistance

Lima, Maria de Lourdes; Cruz, Thomaz; Rodrigues, Luiz Erlon; Bomfim, Olívia; Melo, Juliana Oliveira de; Correia, Raquel; Porto, Mirna; Cedro, A; Vicente, Eliézer

doi:10.1016/j.diabres.2008.11.019

Cited by 83 publications

(38 citation statements)

References 23 publications

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“…However, in recent years, a great deal of research has focused on the physiological and therapeutic properties of this ion. Mg depletion has metabolic effects that include impaired insulin metabolism, hyperlipidemia, and accelerated atherosclerosis [5,19]. However, there are few studies on subjects with GDM in the literature, and those studies have limitations such as small subject populations and Mg detection techniques.…”

Section: Discussionmentioning

confidence: 99%

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Alterations of Ionized and Total Magnesium Levels in Pregnant Women with Gestational Diabetes Mellitus

Taşdemir¹,

Taşdemir²,

Kılıç³

et al. 2014

Gynecol Obstet Invest

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Background/Aims: The aim of this prospective study was to determine ionized and total magnesium (Mg) levels in pregnant subjects with and without gestational diabetes mellitus (GDM). Methods: Eighty-five women, 26-28 weeks pregnant, were recruited for routine oral glucose tolerance tests (OGTT); 45 had normal OGTT results and 40 were diagnosed with GDM. Electrolyte levels, including ionized and total Mg, were analyzed. Results: Gestational age and BMI were similar between the two groups (p = 0.800, p = 0.025). Multivitamin use was higher in the control group (p = 0.036). Fasting blood glucose was higher in the GDM group (p < 0.001). The median total Mg levels were 1.9 mg/dl (range 1.6-2.2) in the control group and 1.8 mg/dl (range 1.2-2.1) in the GDM group (p < 0.001). The median ionized Mg levels were 0.5 mmol/l (range 0.4-0.6) in the control group and 0.4 mmol/l (range 0.4-0.5) in the GDM group (p < 0.001). Conclusion: Our study revealed a relationship between low total and ionized Mg levels and GDM, as in type 2 diabetes mellitus (DM). The literature regarding type 2 DM and our findings suggest that Mg is the key ion in the pathophysiology of GDM. Low-dose Mg supplementation was not related to GDM; however, pharmacological doses in the various stages of pregnancy could be beneficial and should be investigated.

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Section: Discussionmentioning

confidence: 99%

“…Many studies in the literature have demonstrated the role of Mg ions in the pathogenesis of type 2 DM [5,6,7]. The similarity between the pathogenesis of type 2 DM and GDM makes the relationship between Mg and GDM reasonable.…”

Section: Introductionmentioning

confidence: 99%

Alterations of Ionized and Total Magnesium Levels in Pregnant Women with Gestational Diabetes Mellitus

Taşdemir¹,

Taşdemir²,

Kılıç³

et al. 2014

Gynecol Obstet Invest

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“…On the other hand, hypomagnesemia has been reported to occur in 13.5-47.7% of nonhospitalized patients with type 2 diabetes compared with 2.5-15% among their counterparts without diabetes [ 34 ] . Hypomagnesemia was observed in 23.2% and intracellular magnesium depletion in 36.1% of patients with metabolic syndrome [ 56 ] . A strong inverse relationship between magnesium levels in serum and presence of metabolic syndrome was observed by Evangelopoulos and coworkers [ 57 ] .…”

Section: Magnesium De Fi Ciency and Type 2 Diabetesmentioning

confidence: 99%

Magnesium Deficiency in Type 2 Diabetes

Chaudhary

2012

Magnesium in Human Health and Disease

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Key PointsMagnesium is the second most abundant intracellular cation which is widely distributed in plant • and animal foods. Magnesium de fi ciency is actually fairly common, and low magnesium intake may play a role in the • development of type 2 diabetes. Magnesium supplementation has been shown to improve insulin sensitivity and diabetes mellitus. • Magnesium de fi ciency is associated with the development of atherosclerotic cardiovascular • diseases.

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“…It acts as co-factor in many cellular processes [24]. It was observed that its deficiency in diet leads to diabetes [25]; therefore endless efforts have been employed to design and synthesis of chemosensors for magnesium sensing [26][27][28]. However, most of them have poor selectivity due to interference of other ions like Ca 2+ and Ba 2+ [29].…”

Section: Resultsmentioning

confidence: 99%

Design and Synthesis of Novel Fluorescent Phthalimide Based Silatranes: Ratiometric Estimation of Mg2+ Ion

Singh¹,

Mangat²,

Sharma³

et al. 2017

Asian J. Chem.

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Serum and intracellular magnesium deficiency in patients with metabolic syndrome—Evidences for its relation to insulin resistance

Cited by 83 publications

References 23 publications

Alterations of Ionized and Total Magnesium Levels in Pregnant Women with Gestational Diabetes Mellitus

Alterations of Ionized and Total Magnesium Levels in Pregnant Women with Gestational Diabetes Mellitus

Magnesium Deficiency in Type 2 Diabetes

Design and Synthesis of Novel Fluorescent Phthalimide Based Silatranes: Ratiometric Estimation of Mg2+ Ion

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