Serum androgen levels in men: impact of health status and age

Schatzl, Georg; Madersbacher, Stephan; Temml, Christian; Krenn-Schinkel, Karin; Nader, Andreas; Sregi, Gabor; Lapin, Alexander; Hermann, Martin; Berger, Peter; Marberger, Michael

doi:10.1016/s0090-4295(02)02252-5

Cited by 61 publications

(49 citation statements)

References 21 publications

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“…28,36,40 Nevertheless, there is evidence that men with low testosterone levels have higher Gleason grades and worse outcomes than the prostate cancers that develop in men with normal testosterone. [56][57][58][59] Unfortunately, we do not have clinical data for our cases, but it seems reasonable to assume that as they were predominantly detected by clinical symptoms, they had more advanced forms of CaP. Longer AR CAG repeats reduce the transactivation ability of the AR, and the leucine variant of SRD5A2 V89L decreases the amount of DHT available to bind to the AR (see Figure 1), suggesting that there could be a common mechanism for early onset CaP predisposition involving reduced transcription of genes that are regulated by the AR.…”

Section: Discussionmentioning

confidence: 99%

Association between hormonal genetic polymorphisms and early-onset prostate cancer

Forrest

Edwards

Houlston

et al. 2005

Prostate Cancer Prostatic Dis

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We investigated the association between seven polymorphisms in four candidate genes involved in vitamin D and androgen metabolism with early-onset prostate cancer (CaP) risk. The polymorphisms were genotyped in 288 UK males who were diagnosed with CaP at the age of 55 y or younger and up to 700 population-based controls. An additional 50 cases (not selected for age) and 76 controls were also genotyped. Short (p22 repeats) AR (CAG) n repeats were associated with a significantly reduced risk of early onset CaP (OR 0.68, 95% CI 0.50-0.91) compared with men with long (422) repeats. Men homozygous for the leucine variant of SRD5A2 p.89V4L were also found to be at a significantly increased risk of CaP compared with men who were homozygous for the valine allele (OR 1.84, 95% CI 1.15-2.98). No associations were found with the AR (GGC) n , CYP17 Msp A1 I, VDR Taq I, SRD5A2 (TA) n and p.49A4T polymorphisms and CaP risk. These findings suggest that common polymorphisms in the AR and SRD5A2 genes may be associated with early-onset CaP in British men.

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Section: Discussionmentioning

confidence: 99%

Association between hormonal genetic polymorphisms and early-onset prostate cancer

Forrest

Edwards

Houlston

et al. 2005

Prostate Cancer Prostatic Dis

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“…As early as 50-60 years ago it was realized that aging is accompanied by significant reduction in testosterone levels [97,98]. Although some follow-up studies failed to detect age-related decline in plasma testosterone levels in older men [99][100][101][102][103][104], subsequent population-based cross-sectional and longitudinal studies have confirmed progressive loss of testosterone with aging in healthy men [96,[105][106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122]. Mirroring this decline in plasma testosterone concentration is an age associated increase in sex-hormonebinding globulin (SHBG) level [117], a major plasma carrier of testosterone, resulting in even more dramatic decreases in unbound free testosterone [110,[123][124][125], and weakly bound bioavailable testosterone [126,127].…”

Section: Humansmentioning

confidence: 99%

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Zaidi¹

2013

TOLSJ

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Steroid hormones are lipophilic, low-molecular weight organic compounds all of which are derived from cholesterol. They are primarily synthesized by steroidogenic glands such as gonads (ovary and testis), the adrenal gland and, during pregnancy, by the placental trophoblasts. Limited steroid synthesis also takes place in the brain. Steroid hormones are crucial for the proper functioning of the body. They mediate a wide variety of vital physiological functions, ranging from maintaining normal reproductive function and secondary sexual characteristics, to regulating virtually every metabolic process in the body. Like many age-related endocrine disorders, aging also progressively impacts the tissue-specific synthesis and secretion of steroid hormones. The goal of this review is to summarize the effects of aging on steroid hormone synthesis and secretion by the adrenal gland and gonads of both human and experimental animal models, to describe the potential involvement of excessive oxidative stress in mediating age-related alterations in steroidogenesis, and to discuss the possible underlying mechanisms involved.

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“…However, there is no consensus on possible effects of testosterone on LUTS. Schatzl et al (2003) found that hypogonadism was seen approximately one-fifth of elderly men with LUTS, but it had no impact on symptom status. Litman et al (2007) found an inverse correlation between symptoms of LUTS and plasma total and bioavailable testosterone but this relationship disappeared after statistical adjustment for age.…”

Section: Testosterone Deficiency Linked To Lutsmentioning

confidence: 95%

Testosterone Deficiency Linked to Lower Urinary Tract Symptoms

Kim¹

2012

Sex Hormones

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Serum androgen levels in men: impact of health status and age

Cited by 61 publications

References 21 publications

Association between hormonal genetic polymorphisms and early-onset prostate cancer

Association between hormonal genetic polymorphisms and early-onset prostate cancer

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Testosterone Deficiency Linked to Lower Urinary Tract Symptoms

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