Serum anti-Müllerian hormone concentrations in stallions: Developmental changes, seasonal variation, and differences between intact stallions, cryptorchid stallions, and geldings

Claes, A.; Ball, Barry A.; Almeida, Juliana Lopes; Corbin, C. J.

doi:10.1016/j.theriogenology.2013.03.019

Cited by 68 publications

(62 citation statements)

References 27 publications

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“…Olgumuzdaki serum AMH (yarı ömrü 1,5-2 gün) ölçümü hCG uyarı testinden iki gün sonra yapıldı. Bu nedenle, uygulanan hCG sonrasında artan intratestiküler testosteron düzeyinin, sertoli hücrele-rinden sentezlenen AMH'yı güçlü bir şekilde inhibe ettiği ve yüksek olması beklenen serum AMH düze-yinin normal sınırlara çekilmiş olabileceğini düşün-mekteyiz (14,15) . Bu ilişkiyi net olarak açıklayabilmek için, orşiopeksi sonrasında, hCG testi ile sentezlenen testosteron etkisinin geçtiği bir dönemde, serum AMH düzeyinin yine ölçülmesi planlandı.…”

Section: Discussionunclassified

A Rare Cause of a 46,XY Disorders of Sex Development: Persistent Mullerian Duct Syndrome

Acar¹,

Paketçi²,

Önay³

et al. 2017

BUCH

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ÖZPersistan müller kanalı sendromu (PMKS) görece nadir görülen 46,XY cinsiyet gelişim bozukluğudur ve klinik olarak normal dış genital yapıya sahip erkeklerde inmemiş testis, uterus ve fallop tüpleri gibi müller kanal türevlerinin varlığı ile karakterizedir. Bu hastalık sıklıkla müller yapıların regresyonunda rol oynayan anti-Müllerian hormon (AMH) veya onun reseptörü olan AMH reseptör tip 2 (AMRHR2) genindeki genetik bozukluğun sonucunda ortaya çıkmaktadır. Genetik nedenleri ortaya konulmuş olguların %45'inde AMHR2 mutasyonu saptandığı bildirilmektedir. En sık baş-vuru bulguları bilateral kriptorşidizm veya transvers testiküler ektopidir. Uterus ve tüplerin varlığı genellikle kriptorşidizm için yapılan ameliyat sırasında saptanmaktadır. Burada, bilateral inmemiş testis nedeni ile yapılan laparoskopik girişim sırasında müller yapılar (uterus ve fallop tüpleri) saptanan ve önceden bildirilen bir homozigot AMHR2 mutasyonu tanımlanan PMKS'li bir olgu sunulmuştur.Anahtar kelimeler: Anti-müllerian hormone, inmemiş testis, Persistan müller kanalı sendromu ABSTRACTPersistent müllerian duct syndrome (PMDS) is a relatively rare form of a 46,XY disorders of sex development and clinically characterized by undescended testes and the presence of mullerian duct derivatives such as a uterus and fallopian tubes in males with normal external genitalia. The disease is frequently caused either by the genetic defect of the anti-müllerian hormone (AMH) or its receptor AMH receptor type 2 (AMHR2) gene. AMHR2 mutations have been reported in 45% of genetically proven cases with PMDS. The most common referral findings are bilateral cryptorchidism or transverse testicular ectopia. The presence of uterus and tubes is usually detected during surgery for cryptorchidism. Herein we have presented a PMDS patient with previously reported homozygous AMHR2 mutation, in whom müllerian structures (uterus and fallopian tubes) were detected during laparoscopic intervention performed with the indication of bilateral undescended testis.

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A Rare Cause of a 46,XY Disorders of Sex Development: Persistent Mullerian Duct Syndrome

Acar¹,

Paketçi²,

Önay³

et al. 2017

BUCH

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“…A higher concentration of AMH in intact dogs than in castrated dogs has been reported previously (Ano and others 2014). Likewise, evaluating AMH concentrations in castrated, intact and cryptorchid stallions, Claes and others (2013) found significantly higher concentrations of AMH in intact and cryptorchid stallions than in castrated stallions. Moreover, measurement of serum AMH concentration has been indicated as a reliable method to determine the presence of testicular tissue in humans (Lee and others 1997).…”

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confidence: 88%

“…Ano and others (2014) observed a considerably higher concentration of AMH in a cryptorchid dog with Sertoli cell tumour than in intact dogs. Claes and others (2013) reported higher concentrations of AMH in cryptorchid stallions than in intact stallions. Nevertheless, the effect of cryptorchidism on testicular secretion of AMH in dogs remains to be elucidated in further studies with more cases and controls.…”

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confidence: 88%

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Anti‐Müllerian hormone: a potential biomarker for differential diagnosis of cryptorchidism in dogs

et al. 2014

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“…), serum anti‐Müllerian hormone (AMH) (Claes et al . ), serum androstenedione (Illera et al . ) and faecal oestrogens (Palme et al .…”

Section: Quantity and Quality Of Evidencementioning

confidence: 99%

What is the best test for cryptorchidism?

Parker¹

2015

Equine Veterinary Education

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Serum anti-Müllerian hormone concentrations in stallions: Developmental changes, seasonal variation, and differences between intact stallions, cryptorchid stallions, and geldings

Cited by 68 publications

References 27 publications

A Rare Cause of a 46,XY Disorders of Sex Development: Persistent Mullerian Duct Syndrome

A Rare Cause of a 46,XY Disorders of Sex Development: Persistent Mullerian Duct Syndrome

Anti‐Müllerian hormone: a potential biomarker for differential diagnosis of cryptorchidism in dogs

What is the best test for cryptorchidism?

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