Serum anti-Müllerian hormone, inhibin B, and total inhibin levels in women with hypothalamic amenorrhea and anorexia nervosa

Luisi, Stefano; Ciani, Valentina; Podfigurna-Stopa, Agnieszka; Lazzeri, Lucia; Pascalis, Flavio De; Męczekalski, Błażej

doi:10.3109/09513590.2011.579664

Cited by 24 publications

(11 citation statements)

References 23 publications

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“…This same group (24) also reported that women with HH had higher AMH levels and a higher mean ovarian volume compared with controls. These findings are also in discordance with results from a study published by Luisi et al (25)., in which no significant difference in AMH was found between a group of women with hypothalamic amenorrhea and a group of women consisting of healthy controls.…”

Section: Discussioncontrasting

confidence: 85%

Anti-Müllerian Hormone and Ovarian Morphology in Women With Hypothalamic Hypogonadism

Alemyar¹,

Kooi²,

Laven³

2020

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context Different phenotypical features of women with hypothalamic hypogonadism (HH), also known as World Health Organization-1 anovulation, including ovarian morphology, have been scarcely described in large cohorts. Some studies have reported increased levels of anti-Müllerian hormone (AMH) in women with HH. Objective To assess whether women with HH, compared with healthy controls, have increased serum levels of AMH and what proportion of these women erroneously meet the Rotterdam Criteria for Polycystic Ovarian Syndrome (PCOS). Design, Setting and Participants Retrospective cohort study in a Dutch academic medical center including 83 women with neither anovulation nor menstrual cycle disorders (healthy controls), 159 women with HH and 3640 women with PCOS. Age matching was used between the HH and PCOS group (1:2 ratio) to create a second group consisting of 318 age-matched women with PCOS. Intervention None. Main outcome measures AMH levels and ovarian morphology. Results Median AMH serum levels for the HH group were 3.8 (<0.1–19.8), compared with 7.5 (<0.1–81.0) in the PCOS group and 1.9 (<0.1–21.5) in the control group (P < 0.001). In the HH group, 58 (36%) erroneously met the Rotterdam Criteria for PCOS (meeting 2 of 3 criteria). Conclusions AMH levels are increased in women with HH. We hypothesize that this increase, although there was no increase in follicle count, may be explained by the presence of a relatively large pool of antral follicles smaller than 2 mm in diameter, that are undetectable by transvaginal ultrasound. This study highlights the importance of measuring gonadotropins and estradiol before diagnosing a patient with PCOS.

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Section: Discussioncontrasting

confidence: 85%

Anti-Müllerian Hormone and Ovarian Morphology in Women With Hypothalamic Hypogonadism

Alemyar¹,

Kooi²,

Laven³

2020

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…Previous studies on ovarian function and TM mainly focused on ovarian reserve and generally supported an impairment: AMH and AFC are consistently lower [4,[7], [8], [9], [10], [11]]. Our data is in agreement with these findings since both biomarkers resulted reduced in exposed women.…”

Section: Discussionsupporting

confidence: 92%

“…Recent studies also revealed that patients with TM have lower levels of anti-Mullerian hormone (AMH) and reduced antral follicular count (AFC), suggesting that the peripheral excess of iron may also be toxic locally to the gonads, harming the ovarian reserve [4,[7], [8], [9], [10], [11]]. In addition, iron excess, in particular non-transferrin-bound iron and its redox active form, may actually impact on oocyte quality.…”

Section: Introductionmentioning

confidence: 99%

Oocyte quality in women with thalassaemia major: insights from IVF cycles

Mensi

Borroni

Reschini

et al. 2019

European Journal of Obstetrics & Gynecology and Reproductiv

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Background Women with thalassaemia major typically experience hypogonadotropic hypogonadism because of the toxic effects of iron overload on the anterior pituitary. Moreover, in affected women, serum anti-Mullerian hormone (AMH) and antral follicle count (AFC) are also shown to be reduced, suggesting that the peripheral excess of iron could also harm the ovarian reserve. To date, the detrimental effects of the disease on oocyte quality have not been investigated. Materials and methods Women with thalassaemia major who underwent in vitro fertilization (IVF) cycles were retrospectively identified over a 9 years period. They were matched (with a 1:5 ratio) by study period and age to a control group of infertile women undergoing IVF. Embriological variables were compared between the two groups. The primary outcome was the rate of top quality embryos. Results Twenty-one women with thalassaemia major (exposed group) and 105 controls (unexposed group) were ultimately included. Serum AMH was 0.6 [0.2–1.8] and 1.5 [0.7–3.5] ng/ml, respectively (p = 0.05). AFC was 4 (1–7.5) and 11 (5.5–16), respectively (p < 0.001). The total dose of gonadotropins used was higher in exposed women but the number of retrieved oocytes and oocytes used did not differ. The fertilization rate was higher in exposed compared to unexposed women, being 100% (76–100%) and 75% (50–100%). respectively (p = 0.03). The cleavage rate was also higher, being 75% (39–100%) and 50% (29–64%), respectively (p = 0.04). In contrast, the rate of top quality embryos did not differ, being 20% (0–76%) and 25% (5–50%), respectively (p = 0.98). Conclusions Despite lower ovarian reserve, oocyte quality is not significantly affected in women with thalassaemia major.

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“…Investigators concluded that both AMH and AFC are accurate predictors of excessive response and both tests appear to have clinical value [3]. Luisi et al [10] more recently showed that secretion of AMH is not influenced by the hypothalamic-ovarian axis activity and is not impaired in hypothalamic amenorrhea. These data also indirectly supports that AMH can also be an excellent marker of ovarian reserve in neuroendocrine forms of amenorrhea [10].…”

Section: Discussionmentioning

confidence: 99%

Serum anti-Mullerian hormone levels correlate with ovarian response in idiopathic hypogonadotropic hypogonadism

Sönmezer

Özmen

Atabekoglu

et al. 2012

J Assist Reprod Genet

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Purpose The role of serum AMH levels in prediction of ovarian response in idiopathic hypogonadotropic hypogonadism (IHH) was evaluated. Material method(s) Twelve patients with IHH underwent controlled ovarian hyperstimulation (COH) for IVF were enrolled in this prospective study. Serum AMH levels were studied on the 2nd or 3rd day of an induced menstrual cycle by a preceding low-dose oral contraceptive pill treatment. A fixed dose (150-300 IU/day) of hMG was given in all COH cycles. Correlations between serum AMH levels, COH outcomes and embryological data were investigated. Results Mean serum AMH levels was 3.47±2.15 ng/mL and mean serum peak estradiol was 2196±1705 pg/mL. Mean number of follicles >14 mm, >17 mm on hCG day and MII oocytes were 4.14±3.2, 4±2.5 and 7.28±3.5, respectively. Mean number of grade A embryos and transferred embryos were 3.28 ± 2.4 and 2.5 ± 0.7, respectively. The clinical pregnancy rate per patient was 41.6 % (5/12). Positive correlations were observed between serum AMH levels and MII oocytes (r00.84), grade A embryos (r00.85), serum peak estradiol levels (r00.87), and number of follicles >14 mm (r00.83) and >17 mm (r00.81) on hCG day, respectively. Conclusion AMH appears as a promising marker of ovarian response in patients with IHH undergoing IVF.

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Serum anti-Müllerian hormone, inhibin B, and total inhibin levels in women with hypothalamic amenorrhea and anorexia nervosa

Abstract: The present data showed that neuroendocrine forms of amenorrhea are associated with an impaired inhibin secretion while not AMH. These data indirectly support that AMH is an excellent marker of ovarian reserve and its secretion is not influenced by the hypothalamic-ovarian axis activity.

Cited by 24 publications

References 23 publications

Anti-Müllerian Hormone and Ovarian Morphology in Women With Hypothalamic Hypogonadism

Anti-Müllerian Hormone and Ovarian Morphology in Women With Hypothalamic Hypogonadism

Oocyte quality in women with thalassaemia major: insights from IVF cycles

Serum anti-Mullerian hormone levels correlate with ovarian response in idiopathic hypogonadotropic hypogonadism

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