Serum anti‐Müllerian hormone level as a predictor of poor ovarian response in in vitro fertilization patients

Abstract

Purpose To evaluate the clinical value of day 3 serum anti-Müllerian hormone (AMH) compared with day 3 serum follicle-stimulating hormone (FSH) and human chorionic gonadotropin (hCG) day estradiol (E2) levels and antral follicle count (AFC) in the prediction of poor ovarian response in controlled ovarian hyperstimulation (COH). Methods AMH, FSH and AFC on day 3 as well as hCG day E2 levels were determined in 164 subjects. Receiver operating curve analyses and area under curves (AUC) of the study parameters were performed. Predictive values of the levels of day 3 AMH, FSH, AFC, and hCG day E2 as clinical parameters of ovarian response to COH were studied. Results Thirty-eight women were defined as poor responders. The day 3 AMH and hCG day E2 levels and AFC of normal responders were significantly higher than those of the poor responders. In predicting poor response, the AUC of day 3 AMH level was significantly higher than that of day 3 FSH level but was similar to the hCG day E2 level. Day 3 AMH, FSH and hCG day E2 levels and AFC were found to predict a poor response. Day 3 AMH and hCG day E2 levels were more predictive compared with day 3 FSH level and AFC. The cut-off level of AMH was B2 with a sensitivity of 78.9% and a specificity of 73.8%. Conclusion Day 3 AMH has the ability to predict a poor response to COH and it is more predictive than day 3 FSH and AFC.

Serum Anti-müllerian hormone, follicle stimulating hormone and antral follicle count measurement cannot predict pregnancy rates in IVF/ICSI cycles

“…In our previous study we found that an AMH cut-off level of 2 ng/ml could predict poor response with a sensitivity of 78.9% and specificity of 73.8% [32]. In another study we found that an AMH cut-off level of 3.3 ng/mL predicted ovarian hyperstimulation syndrome (OHSS) with a sensitivity of 90% and a specificity of 71%.…”

Anti-Müllerian hormone levels as a predictor of the pregnancy rate in women of advanced reproductive age

“…A relatively new marker, anti-müllerian hormone (AMH) was evaluated by several study groups as a marker of ovarian response [10,11]. AMH, a member of the transforming growth factor-beta super-family, is mainly secreted by the granulosa cells of ovarian early developing follicles.…”

Diagnosis of Polycystic Ovary Syndrome: AMH in combination with clinical symptoms

“…It also has minimal inter-and intracycle variability [6,7]. In clinical practice, it is useful for the prediction of poor responders [8] and ovarian hyperstimulation syndrome (OHSS) [9]. Moreover, it is positively correlated with pregnancy rates [10,11].…”