Serum anti-mullerian hormone levels in the main phenotypes of polycystic ovary syndrome

Şahmay, Sezai; Atakul, Nil; Öncül, Mahmut; Tüten, Abdullah; Aydoğan, Begüm; Seyisoğlu, Hakan

doi:10.1016/j.ejogrb.2013.05.019

Cited by 68 publications

(51 citation statements)

References 28 publications

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“…In a previous study [29], the highest AMH levels were found in cases in which all three main diagnostic criteria (PCOM, OA, and HA) were used. AMH levels correlate best with PCOM, and OA contributes to increased AMH levels.…”

Section: Discussionmentioning

confidence: 78%

Diagnosis of Polycystic Ovary Syndrome: AMH in combination with clinical symptoms

Şahmay

Aydın

Öncül

et al. 2013

J Assist Reprod Genet

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Purpose We assessed the utility of using anti-Müllerian hormone (AMH) and clinical features of polycystic ovary syndrome (PCOS), polycystic ovarian morphology (PCOM), oligo/amenorrhea (OA), and hyperandrogenism (HA) for diagnosing PCOS, and compared their diagnostic accuracy with those of classical diagnostic systems. Methods A total of 606 females were admitted to a university hospital with menstrual irregularities or symptoms of hyperandrogenism were enrolled in this cross-sectional study. Fasting blood samples were collected. Pelvic and/or abdominal ultrasonography and clinical examination were performed. Patients were evaluated for the presence of PCOS according to conventional diagnostic criteria. The diagnostic performance of using serum AMH levels alone and in various combinations with the clinical features of PCOM, OA, and HA were investigated. Results For the diagnosis of PCOS, the combination of OA and/or HA with AMH showed 83 % sensitivity and 100 % specificity according to the Rotterdam criteria; 83 % sensitivity and 89 % specificity according to the National Institutes of Health (NIH) criteria; and 82 % sensitivity and 93.5 % specificity according to the Androgen Excess Society (AES) criteria. Conclusions The serum AMH level is a useful diagnostic marker for PCOS and is correlated with conventional diagnostic criteria. The combination of AMH level with OA and/ or HA markedly increased the clinical scope for PCOS diagnosis and can be introduced as a possible objective criterion for the diagnosis of this disease.

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Section: Discussionmentioning

confidence: 78%

Diagnosis of Polycystic Ovary Syndrome: AMH in combination with clinical symptoms

Şahmay

Aydın

Öncül

et al. 2013

J Assist Reprod Genet

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“…AMH serum levels seem to be related to severity of PCOS -women with classic phenotype have the highest serum AMH levels [5,44]. Supporting these findings, Tal et al reported that 97% of women with AMH > 10 ng/mL presented PCOS and that AMH correlated positively with LH, total testosterone, and dehydroepiandrosterone sulphate.…”

Section: Amh and Pcos Phenotypesmentioning

confidence: 88%

“…Stężenie AMH odzwierciedla stopień nasilenia zaburzeń w PCOS -najwyższe stężenia AMH obserwuje się u kobiet z fenotypem klasycznym [5,44]. Dla potwierdzenia tej tezy Tal i wsp.…”

Section: Amh a Fenotypy Pcosunclassified

Hormon anty-müllerowski i zespół policystycznych jajników

Łebkowska

Kowalska

2015

Endokrynologia Polska

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Anti-Müllerian hormone (AMH) is a glycoprotein, a member of the transforming growth factor β family, reflecting the number of ovarian antral follicles. Polycystic ovary syndrome (PCOS) is a common endocrinopathy predisposing to infertility, and metabolic and cardiovascular complications. In our review, we discuss the role of AMH in PCOS pathophysiology and its clinical applications according to the published studies. Improvement of AMH assay validity will allow the clinical utility of this valuable biomarker to be widened.

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“…Circulating concentrations of AMH are significantly higher in women with PCOS than in age-matched controls [9,10].…”

Section: Introductionmentioning

confidence: 85%

Relation of antimullerian hormone with the clinical signs of hyperandrogenism and polycystic ovary morphology

Şahmay¹,

Aydın

Atakul³

et al. 2013

Gynecological Endocrinology

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The relation of antimullerian hormone (AMH) levels with the clinical and biochemical markers of polycystic ovary syndrome (PCOS) could be different. A total of 463 PCOS patients were evaluated in this cross-sectional study. Groups were constructed according to polycystic ovarian morphology (PCOM) and menstrual cycle-length. The relation of serum AMH with androgenic hormones, menstrual cycle-length and clinical signs of PCOS were investigated. A powerful positive relation was found between the PCOM and AMH levels (odds ratio = 2.49). There was a negative correlation between age and AMH level (p < 0.001, r[correlation coefficent] = -0.155). Positive correlations were found between luteinizing hormone (LH) and AMH (p < 0.001, r = 0.25) and also between cycle length and AMH (p < 0.01, r = 0.27). We found a negative week correlation between AMH and follicle-stimulating hormone (FSH) (p = 0.01, r = -0.19). After controlling main androgenic hormones, AMH was found to be correlated with the Ferriman-Gallway score (p = 0.03, r = 0.18). There was a positive relationship between hirsutism and AMH (odds ratio = 1.43), but no correlation between AMH and other parameters of clinical hyperandrogenism like hair-loss, acne and seborrhea were identified. The strongest relation was presented between the AMH levels and PCOM. Also, cycle-length correlated well with the AMH levels. The relationship between hirsutism and AMH is found to be independent from androgenic hormones.

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Serum anti-mullerian hormone levels in the main phenotypes of polycystic ovary syndrome

Cited by 68 publications

References 28 publications

Diagnosis of Polycystic Ovary Syndrome: AMH in combination with clinical symptoms

Diagnosis of Polycystic Ovary Syndrome: AMH in combination with clinical symptoms

Hormon anty-müllerowski i zespół policystycznych jajników

Relation of antimullerian hormone with the clinical signs of hyperandrogenism and polycystic ovary morphology

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