Serum antibodies to LDH-C4

Shelton, Joyce A.; Goldberg, Erwin

doi:10.1016/0165-0378(85)90006-3

Cited by 10 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Data obtained from the literature support the finding that sperm‐specific LDHC4 isozyme is a cognate antigen for ASA also in human sperm. Shelton and Goldberg 14 reported ASA raised against sperm‐specific lactate dehydrogenase in human serum in about 10% of infertile males and females and in about 20% of vasectomized males. It has also been demonstrated that immunization of female mice, rabbits and baboon with LDHC4 purified from mouse testis suppressed the fertility of these animals 15 .…”

Section: Discussionmentioning

confidence: 99%

Identification of Evolutionary Conserved Mouse Sperm Surface Antigens by Human Antisperm Antibodies (ASA) from Infertile Patients

Paradowska

Bohring

Krause³

et al. 2006

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of Evolutionary Conserved Mouse Sperm Surface Antigens by Human Antisperm Antibodies (ASA) from Infertile Patients

Paradowska

Bohring

Krause³

et al. 2006

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

“…Active immunization of various species of animals causes a reduction (up to 50%) of fertility by mechanism(s) primarily involving postfertilization embryonic mortality, besides causing agglutination of sperm (12). LDH-C4 is a poor immunogen: active immunization of mice with whole sperm does not produce antibodies to LDH-C4 (14), and sera from immunoinfertile patients (both male and female) do not have antibodies to LDH-C4 (15). Goldberg and associates have attempted to increase the immunogenicity of this molecule by expressing it in vaccinia virus as a recombinant vector.…”

Section: Lactate Dehydrogenase (Ldh)-c4mentioning

confidence: 99%

Application of sperm antigens in immunocontraception

Naz¹

1996

Front Biosci

View full text Add to dashboard Cite

Development of a vaccine(s) based on sperm antigens represents a promising approach for contraception. The utility of an antigen in immunocontraception is contingent upon its tissue specificity, involvement in human fertility, and immunogenicity. A number of antigens have been characterized from the sperm surface. Notable among these are LDH-C4, RSA antigens, PH-20, SP 1U, HSA-63, FA-1, FA-2 and CS-1. These antigens have been proposed as potential candidates for the development of contraceptive vaccine(s). Their current status, application, relative merits, and immunogenicity in immunocontraception are discussed in this review.

show abstract

“…Recently, work has been going on to identify monoclonal antibodies to isolate and characterize sperm membrane antigens that represent appropriate candidates for development into antisperm vaccines [71].…”

Section: Antisperm Vaccinementioning

confidence: 99%

New developments in contraceptive technology

Singh

1991

Adv Contracept

View full text Add to dashboard Cite

The demand for fertility control is expected to increase in the next two to three decades as the number of couples in the reproductive age groups in developing countries alone is expected to grow to nearly 1 billion. The crucial issues in the future will therefore be aimed at optimizing the use of currently available methods and making them safe, effective and acceptable, with minor alterations in composition or delivery system. In addition, there should be new developments in contraceptive technology. In this paper, an update will be given of the work presently underway on improving existing methods of fertility control and also on the research being undertaken on possible new contraceptive methods. It is extremely difficult to predict with certainty the future direction of contraceptive technology. Workers and 'seers' in the field of contraceptive research predict no completely novel breakthrough in this century at least. Yet there is hope for some novel breakthrough in contraceptive technology from the work which is being done at present by independent researchers. Perhaps, these may bear fruit in the twenty-first century.

show abstract

Serum antibodies to LDH-C4

Cited by 10 publications

References 1 publication

Identification of Evolutionary Conserved Mouse Sperm Surface Antigens by Human Antisperm Antibodies (ASA) from Infertile Patients

Identification of Evolutionary Conserved Mouse Sperm Surface Antigens by Human Antisperm Antibodies (ASA) from Infertile Patients

Application of sperm antigens in immunocontraception

New developments in contraceptive technology

Contact Info

Product

Resources

About