Serum Antioxidant Parameters are Significantly Increased in Patients with Type 2 Diabetes Mellitus after Consumption of Chinese Propolis: A Randomized Controlled Trial Based on Fasting Serum Glucose Level

Gao, Weina; Li, Pu; Wei, Jingyu; Yao, Zhanxin; Wang, Yawen; Shi, Tala; Zhao, Liancheng; Jiao, Changya; Guo, Changjiang

doi:10.1007/s13300-017-0341-9

Cited by 59 publications

(71 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In almost all studies, both genders were enrolled as participants, and mean body mass index was nearly 26.5 kg/m 2 . FPG and HbA1C were reported in all RTCs (Afsharpour et al, ; El‐Sharkawy et al, ; Fukuda et al, ; Gao et al, ; Samadi et al, ; Zhao et al, ), and fasting insulin was presented in five studies (Afsharpour et al, ; Fukuda et al, ; Gao et al, ; Samadi et al, ; Zhao et al, ). Four RTCs (Fukuda et al, ; Gao et al, ; Samadi et al, ; Zhao et al, ) addressed baseline pharmacotherapy application among subjects, while the two remaining studies (Afsharpour et al, ; El‐Sharkawy et al, ) did not report participant medication.…”

Section: Resultsmentioning

confidence: 99%

“…Table 2 presented information about the basic characteristics of the included studies. Briefly, six RCTs (Afsharpour et al, 2017;El-Sharkawy, Anees, & Van Dyke, 2016;Fukuda et al, 2015;Gao et al, 2018;Samadi et al, 2017;Zhao et al, 2016) comprising 373 subjects were included in the systematic review and meta-analysis. Studies were conducted in Japan (Fukuda et al, 2015), China (Gao et al, 2018;Zhao et al, 2016), Iran (Afsharpour et al, 2017;Samadi et al, 2017), and Egypt (El-Sharkawy et al, 2016).…”

Section: Resultsmentioning

confidence: 99%

“…The mean age of participants was nearly 57. In almost all studies, both genders were enrolled as participants, and mean body mass index was nearly (Afsharpour et al, 2017;El-Sharkawy et al, 2016;Fukuda et al, 2015;Gao et al, 2018;Samadi et al, 2017;Zhao et al, 2016), and fasting insulin was presented in five studies (Afsharpour et al, 2017;Fukuda et al, 2015;Gao et al, 2018;Samadi et al, 2017;Zhao et al, 2016). Four…”

Section: Resultsmentioning

confidence: 99%

“…Besides the efficacy of propolis on glycemic‐related markers of T2DM, studies showed that propolis could be beneficial in ameliorating other metabolic parameters known to be associated with T2DM. Human studies have shown that propolis could ameliorate serum levels of C‐reactive protein (El‐Sharkawy et al, ) and tumor necrosis factor (TNF‐α; El‐Sharkawy et al, ; Zhao et al, ) and enhance insulin in plasma concentration of total polyphenols (Gao et al, ; Zhao et al, ), total flavonoids (Gao et al, ), and glutathione (Gao et al, ; Zhao et al, ), all of which indicated other potential properties of propolis, such as antiinflammatory and antioxidant activities. Animal studies have elucidated that propolis can normalize neutrophil infiltration, as well as inhibit inflammation and improve diabetic wound healing (McLennan et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, positive effects have been reported in people suffering from T2DM in certain trials (Afsharpour, Hashemipour, Khadem-Haghighian, & Koushan, 2017;Samadi, Mozaffari-Khosravi, Rahmanian, & Askarishahi, 2017). However, other trials did not find any significant effect of propolis on T2DM treatment (Fukuda et al, 2015;Gao et al, 2018;Zhao et al, 2016), and findings regarding the efficacy of propolis on fasting plasma glucose (FPG), fasting insulin, and hemoglobin A1C (HbA1C) have remained inconclusive.…”

mentioning

confidence: 99%

See 4 more Smart Citations

The efficacy of propolis on markers of glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis

Karimian

Hadi

Pourmasoumi

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

Background and Objectives The impetus for the current study was to evaluate the efficacy of propolis supplementation on markers of glycemic status in adults with type 2 diabetes mellitus (T2DM). Methods A comprehensive search was conducted in PubMed, Scopus, Cochrane Library, Web of Science, and Google Scholar up to August 2018, identifying randomized controlled trials investigating the effect of propolis supplementation on glycemic markers in adults with T2DM. Cochrane Collaboration tool was used to evaluate the risk of bias assessment. A random‐effects model was applied in the meta‐analysis to compensate for potential heterogeneity among the included studies. Results Six randomized controlled trials comprising 373 participants were included in the systematic review and meta‐analysis. The results of the meta‐analysis revealed significant reductions in fasting plasma glucose (−13.51 mg/dl; 95% CI [−24.98, −2.04]) and hemoglobin A1C (−0.52%; 95% CI [−0.94, −0.10]) concentrations following propolis supplementation. However, no significant lowering effect was observed in fasting insulin levels (−0.53 pmol/L; 95% CI [−1.69, 0.63]) or homeostasis model assessment of insulin resistance (−0.543; 95% CI [−1.72, 0.64]). Conclusion This systematic review and meta‐analysis suggested that propolis supplementation may be effective in controlling glycemic levels for T2DM patients. Further studies are needed to confirm these results.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

The efficacy of propolis on markers of glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis

Karimian

Hadi

Pourmasoumi

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

Does propolis have any effect on rheumatoid arthritis? A review study

Nattagh‐Eshtivani

Pahlavani

Ranjbar

et al. 2022

Food Science & Nutrition

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) is a chronic autoimmune disease in which inflammation and oxidative stress play a key role in its pathophysiology. Complementary therapies along with medications may be effective in the control of RA. Propolis is a natural substance extracted from beehives, which have confirmed anti‐inflammatory and antioxidant effects. The present study aimed to review the possible effects of propolis on inflammation, oxidative stress, and lipid profile in patients with RA. English articles in online databases such as PubMed‑Medline, AMED, Google Scholar, EMBASE, Scopus, and Web of Science databases were searched. Pieces of evidence show that supplementation with propolis may have therapeutic effects on RA patients. Due to increased inflammation and oxidative stress in the affected joints of RA patients, propolis could inhibit the inflammatory cascades by inhibiting the nuclear factor kappa B pathway and reducing reactive oxygen species, malondialdehyde, and interleukin‐17 by increasing some antioxidants. Therefore, inflammation and pain reduce, helping improve and control RA in patients. Further investigations are required with larger sample sizes and different doses of propolis to demonstrate the definite effects of propolis on various aspects of RA.

show abstract

The effect of propolis supplementation in improving antioxidant status: A systematic review and meta‐analysis of controlled clinical trials

Nazari‐Bonab,

Jamilian,

Radkhah

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

The present study aimed to assess the effect of propolis supplementation on oxidative status, a key contributor to the etiology of many chronic diseases. A systematic search of multiple databases, including Web of Science, SCOPUS, Embase, PubMed, and Google Scholar, was conducted from inception to October 2022 to identify articles examining the effect of propolis on glutathione (GSH), glutathione peroxidase (GPX), total antioxidant capacity (TAC), superoxide dismutase (SOD), and malondialdehyde (MDA) levels. The quality of the included studies was evaluated using the Cochrane Collaboration tool. A total of nine studies were included in the final analysis, and a random‐effects model was used to pool the estimated effects. Results showed that propolis supplementation significantly increased the levels of GSH (SMD = 3.16; 95% CI: 1.15, 5.18; I2 = 97.2%), GPX (SMD = 0.56; 95% CI: 0.07, 1.05; p = 0.025; I2 = 62.3%), and TAC (SMD = 3.26; 95% CI: 0.89, 5.62; I2 = 97.8%, p < 0.001). However, the effect of propolis on SOD was not significant (SMD = 0.05; 95% CI: −0.25, 0.34; I2 = 0.0%). Although the MDA concentration was not significantly decreased overall (SMD = −0.85, 95% CI: −1.70, 0.09; I2 = 93.3%), a significant decrease in MDA levels was observed at doses ≥1000 mg/day (SMD = −1.90; 95% CI: −2.97, −0.82; I2 = 86.4) and supplementation durations of less than 11 weeks (SMD = −1.56; 95% CI: −2.60, −0.51; I2 = 90.4). These results suggest that propolis is a safe supplement with a beneficial effect on GSH, GPX, and TAC levels and may be an effective adjunctive therapy for diseases where oxidative stress is a key factor in the etiology. However, further high‐quality studies are necessary to make more precise and comprehensive recommendations given the limited number of studies, clinical diversity, and other limitations.

show abstract

Serum Antioxidant Parameters are Significantly Increased in Patients with Type 2 Diabetes Mellitus after Consumption of Chinese Propolis: A Randomized Controlled Trial Based on Fasting Serum Glucose Level

Cited by 59 publications

References 56 publications

The efficacy of propolis on markers of glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis

The efficacy of propolis on markers of glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis

Does propolis have any effect on rheumatoid arthritis? A review study

The effect of propolis supplementation in improving antioxidant status: A systematic review and meta‐analysis of controlled clinical trials

Contact Info

Product

Resources

About