Serum Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) Levels in Different Grades of Protein Energy Malnutrition

Chowdhury, Serajul Islam; Rahman, Abm Ziaur; Haque, Mahmudul; Nahar, Nazibun; Taher, Abu

doi:10.3329/jbsp.v2i0.978

Cited by 12 publications

(12 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…SGOT and SGPT level in this study were higher in patients with malnutrition compared to control group, but both were still with in normal range. This was consistent with study was done by Chrowdury et al which obtained a result that there was an increase of SGOT and SGPT in patients with malnutrition [20]. In this study, the samples were limited to patients with normal hepatic function marked by normal SGOT and SGPT value.…”

Section: Discussionsupporting

confidence: 91%

Relationship between Cysteine, Interleukin (IL)-2, And Interleukin (IL)-10 in Children with Marasmus Type Malnutrition

Wahyudi

Puryatni

Hernowati

2016

JTLS

View full text Add to dashboard Cite

Malnutrition is one of the health issues in developing countries. The most commonly found malnutrition is the marasmus type. Infection in marasmus patient is the main cause of morbidity and mortality in developing countries. In marasmus, there is a decrease in protein level such as cysteine which is one of the glutathione forming components that plays a significant role in immune system. In malnutrition, there is a disturbance of lymphocyte in the form of down-regulation of type 1 cytokine (IL-2 and IFN-γ) and up-regulation of type 2 cytokine (IL-4 and IL-10). IL-2 is needed for the development of regulatory T produced by thymus and for NK cell cytotoxicity which plays a role in infection process, while IL-10 inhibits activation of lymphocyte T so the cellular immunity reaction ends. Several studies about the relationship between cysteine, IL-2, and IL-10 have been done in malnutrition-patients, but there is no study focusing on patients with marasmus. This study is to find out the relationship between cysteine, IL-2, and IL-10 in patients with marasmus type malnutrition. This study was an observational analytic study using cross-sectional design consisting of 20 children with marasmus type malnutrition and 20 well-nourished children treated in Saiful Anwar Hospital Malang. The cysteine, IL-2, and IL-10 level then measured using Elisa method. Normality and the various test were done. The Pearson correlation test was done to find out the relationship between cysteine and IL-2 level, cysteine and IL-10 level, and IL-2 and IL-10. The standard of cysteine and IL-2 level in children with marasmus is significantly lower than the control group, which was 1.616 ± 1.039 vs 3.298 ± 0.519 pg/mL; p = 0.000 dan 12.38±4.94 vs. 16.58 ± 4.80 pg/mL; p = 0.010, respectively. IL-10 in children with marasmus was significantly higher than control group (19.08± 5.93 vs 10.46 ± 3.90 pg/mL; p = 0.000). The cysteine level was positively correlated to the IL-2 level (p = 0.000; r = 0.71), while the cysteine and IL-10, IL-2 and IL-10 was negatively correlated with p = 0.014; r=-0.53 and p=0.037; r=-0.46 in marasmus. There was a positive correlation between the cysteine and IL-2 level and negative correlation between IL-10 and IL-2 also IL-2 and IL-10 in children with marasmus.

show abstract

Section: Discussionsupporting

confidence: 91%

Relationship between Cysteine, Interleukin (IL)-2, And Interleukin (IL)-10 in Children with Marasmus Type Malnutrition

Wahyudi

Puryatni

Hernowati

2016

JTLS

View full text Add to dashboard Cite

show abstract

“…A study conducted by Hyder et al (2013) explain that the levels of AST and ALT increased on condition of viral hepatitis infection, alcohol use, and cirrhosis of the liver [28]. While the research conducted by Crawdury et al (2007) get different results, which found elevated levels of AST and ALT in marasmic malnutrition patients [29]. In this research that we had excluded patients with liver disease and autoimmune diseases, so there were no differences between the two of groups.…”

Section: Resultsmentioning

confidence: 84%

Cysteine, Malondyaldehide (MDA) and Glutathione (GSH) Levels in Marasmic Type Malnutrition

Cahyani¹,

Puryatni²,

Permatasari³

2017

JTLS

View full text Add to dashboard Cite

Micronutrien deficiency in severe malnutrition will reduce antioxidant capacity that needed for oxidative stress defense. Cysteine, a non-essential amino acid, is one of an important component for reduced gluthatione (GSH). This study aims to prove the difference between the levels of cysteine, MDA and GSH levels in children with marasmic malnutrition and well-nourished children and prove whether there is a relationship between those parameters. Fiftysix patients participated in this study were grouped into two groups of samples that were marasmic type malnutrition group (28 patients) and control groups that were well nourished group (28 patients). Examination begins with a complete laboratory screening, followed by examination of cysteine, MDA and GSH level. Of the 28 patients included in marasmic type malnutrition group consisting of 15 male patients (53.6%) and 13 female patients (46.4%), while the well-nourished group consisted of 13 male patients (46.4%) and 15 female patients (53.6%). The average age is 54.61±56.35 months in the group of marasmic type malnutrition and 48.25±45.34 months in the wellnourished group. By using the Mann Whitney test, there were significant difference between the levels of cysteine and GSH in marasmic malnutrition and control group (p=0.000 and p=0.000 respectively). Spearman correlation test between cysteine and GSH levels, cysteine and MDA levels, MDA and GSH levels in marasmic malnutrition children shows no significant correlation (R = -0.206, p = 0.294; R = -0.036, p = 0.856; R = 0.210, p = 0.284 respectively). In well-nourished group Spearman correlation test between cysteine and GSH levels, cysteine and MDA levels, MDA and GSH levels also shows no significant correlation (R = -0.053, p=0.789; R = -0.146, p = 0.458; R = -0.079, p = 0.688 respectively). From this study it can be concluded that there are significant differences of the levels of cysteine and GSH between severe malnutrition groups compared with the control one. But this study shows no significant correlation between the levels of cysteine and GSH levels in marasmic type malnutrition and well-nourished children.

show abstract

“…This may lead to deposit of more lipids in liver and help the formation of fatty liver. An increased level of ALT and AST in serum in low dietary protein fed rats was due to enhance transamination to metabolize the excess amino acids release from tissue breakdown to compensate low dietary protein 22 . Significantly increased levels of serum ALT and AST in all the excess vitamin A supplemented rats is due to toxic effects of vitamin A on liver 23 .…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary protein against excess vitamin A induced hepatotoxicity in rats

Karar¹,

Agarwal²,

Agarwal³

et al. 2017

Am J Drug Deliv

View full text Add to dashboard Cite

Serum Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) Levels in Different Grades of Protein Energy Malnutrition

Cited by 12 publications

References 4 publications

Relationship between Cysteine, Interleukin (IL)-2, And Interleukin (IL)-10 in Children with Marasmus Type Malnutrition

Relationship between Cysteine, Interleukin (IL)-2, And Interleukin (IL)-10 in Children with Marasmus Type Malnutrition

Cysteine, Malondyaldehide (MDA) and Glutathione (GSH) Levels in Marasmic Type Malnutrition

Effect of dietary protein against excess vitamin A induced hepatotoxicity in rats

Contact Info

Product

Resources

About