SERUM B<sub>12</sub> AND FOLATE CONCENTRATIONS IN MENTAL PATIENTS

Hällström, Tore

doi:10.1111/j.1600-0447.1969.tb06198.x

Cited by 34 publications

(6 citation statements)

References 27 publications

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“…As in the epileptic patients, our results indicate that this is accompanied by evidence of a fall in red cell values in many. This is in agreement with Hallstrom (1969) who reported subnormal whole blood folate levels in six out of nine psychiatric patients with subnormal serum folate levels, but not with Jensen and Olesen (1969b) whose seven patients with low serum levels were said to have normal whole blood values, though again no control data were included. CAUSES OF LOW FOLATE LEVELS In epileptic patients the evidence that anticonvulsant drugs are predominantly responsible for the reported changes in serum, red cell, and CSF folate levels appears convincing, though the mechanism has not been clarified (Chanarin, 1969).…”

Section: Resultssupporting

confidence: 90%

“…Other studies have revealed a prevalence of low serum folate levels in up to 25% of non-epileptic psychiatric patients (Carney, 1967;Hunter, Jones, Jones, and Matthews, 1967;Ibbotson, Dilena, and Horwood, 1967;Hallstrom, 1969;Kallstrom and Nylof, 1969;Jensen and Olesen, 1969b;Reynolds, Preece, Bailey, and Coppen, 1970). The origin and significance of this finding are not yet clear.…”

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confidence: 95%

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Folate metabolism in epileptic and psychiatric patients

Reynolds

Preece

Johnson

1971

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY Serum and red cell folate levels and serum vitamin B12 levels have been estimated in 33 normal controls; 34 epileptic outpatients, 19 of whom also suffered from psychiatric illness; 33 epileptic inpatients with psychiatric illness; and 30 non-epileptic inpatients with psychiatric illness. Significant lowering of serum folate and red cell folate levels was observed in epileptic patients with psychiatric illness, and a less significant fall in red cell folate levels was found in nonepileptic psychiatric patients. Serum folate levels less than 2-5 ng/ml. were found in two controls, seven outpatient epileptics, 29 inpatients, and 10 non-epileptic patients. Red cell folate levels less than 100 ng/ml. were found in two controls, nine outpatient epileptics, 23 inpatient epileptics, and seven non-epileptic patients. A significant correlation was found between serum and red cell folate values in control, epileptic, and non-epileptic patients. In the epileptic patients there was a significant association between low serum and red cell folate levels and the presence of psychiatric illness. The origin and possible significance of these findings are discussed.

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Section: Resultssupporting

confidence: 90%

mentioning

confidence: 95%

Folate metabolism in epileptic and psychiatric patients

Reynolds

Preece

Johnson

1971

Journal of Neurology, Neurosurgery & Psychiatry

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“…Surveys of psychiatric in-patient populations indicate that between 10 and 30% may have low serum folate levels (Carney, 1967;Hallstrom, 1969;Kallstrom & Nylof, 1969;Reynolds et al 1970;Reynolds, 1976;Thornton & Thornton, 1978). The deficiency may be associated with various diagnostic categories but it is most commonly associated with depression (Carney, 1967;Reynolds et al 1970;Reynolds, 1976).…”

Section: Folate Deficiency and Depressionmentioning

confidence: 99%

Folic acid,S-adenosylmethionine and affective disorder

Reynolds¹,

Stramentinoli²

1983

Psychol. Med.

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“…Affective disorders and dementia along with schizophrenia-like psychosis and associated abnormality of behaviour, together with personality disorders are among the main psychiatric conditions associated with drug-induced folate deficiency (Reynolds, 1971). A number of studies have shown depressed folate levels in psychiatric patients (Carney, 1967;Hunter et al, 1967;Hallstrom, 1969;Reynolds et al, 1970).…”

Section: Introductionmentioning

confidence: 99%

Folate metabolism and problem behaviour in mentally handicapped epileptics

Deb

Cowie

Richens

1987

J intellect Disabil Res

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ABSTRACT. Two groups of mentally handicapped residents were studied consisting of 32 epileptics on anti‐epileptic medication and 32 non‐epileptic controls. The epileptic group showed a significantly low serum folate level compared with the non‐epileptic control group. Serum vitamin B12 and behaviour rating did not show any significant difference between two groups. Comparison of patients receiving phenytoin and those who were not showed significantly lower serum folate in the sub‐group receiving phenytoin, but there was no significant difference between the sub‐groups with respect to vitamin B12 or behaviour problem rating.

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SERUM B₁₂ AND FOLATE CONCENTRATIONS IN MENTAL PATIENTS

Cited by 34 publications

References 27 publications

Folate metabolism in epileptic and psychiatric patients

Folate metabolism in epileptic and psychiatric patients

Folic acid,S-adenosylmethionine and affective disorder

Folate metabolism and problem behaviour in mentally handicapped epileptics

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SERUM B12 AND FOLATE CONCENTRATIONS IN MENTAL PATIENTS

Cited by 34 publications

References 27 publications

Folate metabolism in epileptic and psychiatric patients

Folate metabolism in epileptic and psychiatric patients

Folic acid,S-adenosylmethionine and affective disorder

Folate metabolism and problem behaviour in mentally handicapped epileptics

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Product

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SERUM B₁₂ AND FOLATE CONCENTRATIONS IN MENTAL PATIENTS