Serum B-type natriuretic peptide on admission can predict the ‘no-reflow’ phenomenon after primary drug-eluting stent implantation for ST-segment elevation myocardial infarction

Predictive value of soluble suppression of tumourigenicity 2 on myocardial reperfusion

“…Prior studies reported that high serum BNP or Nterminal (NT)-proBNP levels on admission might be an independent predictor of no-reflow/microvascular obstruction after PPCI in patients with STEMI. 18,19 However, BNP and NT-proBNP levels could both be increased by renal dysfunction. 20,21 Therefore, the increase of BNP and NT-proBNP concentrations probably resulted from both renal and cardiac dysfunction.…”

Serum NT-proBNP on admission can predict ST-segment resolution in patients with acute myocardial infarction after primary percutaneous coronary intervention

“…On the other hand, patients in the present study had a rigorous supervised follow-up routine designed to help prevent coronary artery disease. Limited data have suggested a potential link between a STEMI patient's serum BNP level on hospital admission and the probability of not experiencing "no-reflow" after pPCI [26,27]. Compared with BNP, greater attention should be given to NT-proBNP because of its higher serum concentrations that are more easily stabilized and can be more reliably and uniformly tested.…”

“…NT-proBNP secretion is regulated by stress in the ventricular wall as well as neurohumoral factors [28]. Myocardial stretch secondary to left ventricular dysfunction was shown to be the most important stimulus of NT-proBNP elevation [27]. Furthermore, non-STR shortly after successful pPCI indicates sustained transmural injury and correlates with impaired myocardial reperfusion at the microcirculatory level.…”

In-hospital prognostic value of admission plasma B-type natriuretic peptide levels in patients undergoing primary angioplasty for acute ST-elevation myocardial infarction

“…Subsequent studies with varying optimal cut-off values confirmed the value of BNP and N-terminal pro-BNP as a predictor of no-reflow. [6,18] Jeong et al [6] identified the optimal cut-off value of BNP as 90 pg/ml in prediction of no-reflow with positive predictive value of 12% and negative predictive value of 98%. In our study, with the cut-off value of 100 pg/ml, these values were 24.3% and 91%, respectively, for prediction of no-reflow.…”

“…[2,3] In addition to being an independent predictor of short-and long-term mortality, [3,4] BNP has also been shown to be a significant predictor of no-reflow phenomenon in recent studies on primary percutaneous coronary intervention. [5,6] However, each study identified a different optimal cut-off value for prediction of a number of clinical endpoints. The cut-off value for BNP in healthy individuals is 25 pg/ml [7] and the widely accepted optimal cut-off value for BNP to rule out acute heart failure is 100 pg/ml.…”